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Biochemical mechanisms involved in tumor cell penetration of the basement membrane

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Tumor Invasion and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 7))

Abstract

Cancer invasion and metastases is such a highly complex process that it is difficult to study the specific biochemical mechanisms involved. One way to circumvent this problem is to break the process down into a series of defined tumor-host interactions, and then to focus on one type of interaction. For example, past investigators have focused on the interaction of metastatic tumor cells with isolated populations of host cells such as lymphocytes, macrophages, or endothelial cells [1–3]. Those types of experiments were made feasible by technical advances which enabled investigators to obtain pure populations of host cells. With recent advances in the understanding of connective tissue biochemistry [4–7], it is now possible to purify specific components of the host extracellular matrix for use in experiments related to tumor invasion.

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Authors
  1. L. A. Liotta
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  2. S. Garbisa
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  3. K. Tryggvason
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    L. A. Liotta

  2. Frederick Cancer Research Center, Frederick, Maryland, USA

    I. R. Hart

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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London

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Liotta, L.A., Garbisa, S., Tryggvason, K. (1982). Biochemical mechanisms involved in tumor cell penetration of the basement membrane. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_19

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  • DOI: https://doi.org/10.1007/978-94-009-7511-8_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7513-2

  • Online ISBN: 978-94-009-7511-8

  • eBook Packages: Springer Book Archive

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