Abstract
Gossypol (1) is a yellow, phenolic pigment found in the cotton plant1. The compound, both in the free form and as 1:1 complexes with acetic acid and with formic acid, was discovered by the Chinese to be orally active as an antifertility agent in the male2. Interference with spermatogenesis has been demonstrated both in clinical trials in China and in laboratory studies in rats and hamsters in several countries3–9. The principal side-effects revealed in the Chinese studies were low incidences of hypokalemia and of failure to regain fertility on ceasing treatment. Gossypol has also been demonstrated to be an active spermicidal agent and there have been trials of its efficacy as a vaginal spermicide10–17.
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Details of the stability study will be published in the near future
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Matlin, S.A., Zhou, R.H. (1985). Antifertility activity of (—)-gossypol. In: Runnebaum, B., Rabe, T., Kiesel, L. (eds) Future Aspects in Contraception. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4910-2_12
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DOI: https://doi.org/10.1007/978-94-009-4910-2_12
Publisher Name: Springer, Dordrecht
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