Abstract
The successful design, scale-up, and optimization of protein recovery and purification processes is a difficult task that requires collaboration of many disciplines. Computer-aided process design tools can facilitate this task by introducing a common language of communication among the various research and development groups and by providing a total systems approach. Such tools enable chemical/biochemical engineers rapidly to develop, evaluate, and optimize flowsheets for the production and recovery of biological products. This chapter, through an example, demonstrates how such a software design tool[3] can be used in an industrial environment to facilitate process development and flowsheet optimization.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D. Petrides, C.L. Cooney, L.B. Evans, R.P. Field and M. Snoswell (1989). Bioprocess simulation: an integrated approach to process development, Computers and Chem. Eng., 13, 553–561.
L.B. Evans and R.P. Field (1988). Bioprocess simulation: a new tool for process development, BioTechnol., 6, 200–224.
Intelligen, Inc. (1993). Manual of Bio Pro Designer — An Advanced Computing Environment for Designing Integrated Biochemical Processes.
C.A. Siletti (1988). Computer-Aided Design of Protein Recovery Processes, Ph.D. Thesis, Massachusetts Institute of Technology.
D. Petrides, K.G. Abeliotis and S.K. Mallick (1994). EnviroCAD: a design tool for efficient synthesis and evaluation of integrated waste recovery, treatment and disposal processes, Computers & Chem. Eng., 18, S603–S607.
C.L. Cooney, D. Petrides, M. Barrera and L. Evans (1988). Computer-aided design of a biochemical process, in The Impact of Chemistry on Biotechnology, eds M. Phillips, S.P. Shoemaker, R.D. Middlekauff and R.M. Ottenbrite, ACS Symposium Series 362.
C.L. Cooney, J.E. Strong, D. Petrides and L. Evans (1987). Computer-aided design of biochemical recovery processes, in Biochemical Engineering — A Challenge for Interdisciplinary Cooperation, eds H. Chmiel, W.P. Hammes and J.E. Bailey, Gustav Fischer Verlag, Stuttgart — New York.
J.M. Douglas (1988). Conceptual Design of Chemical Processes, McGraw-Hill.
D.P. Petrides (1990). Computer-aided Design of Integrated Biochemical Processes; Development of BioDesigner, Ph.D. Thesis, Department of Chemical Engineering, MIT.
D. Petrides (1994). BioPro designer: An advanced computing environment for modeling and design of integrated biochemical processes, Computer & Chem. Eng., 18, S621–S625.
E.M. Rosen and A.C. Pauls (1977). Computer aided chemical process design: the FLOW TRAN system, Computers & Chem Eng., 1, 11–21.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Chapman & Hall
About this chapter
Cite this chapter
Petrides, D.P., Sapidou, E.S. (1997). Optimization of protein recovery using computer-aided process design tools. In: Goldberg, E. (eds) Handbook of Downstream Processing. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1563-3_24
Download citation
DOI: https://doi.org/10.1007/978-94-009-1563-3_24
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7198-7
Online ISBN: 978-94-009-1563-3
eBook Packages: Springer Book Archive