Abstract
A preliminary investigation of associations between cattle MHC (BoLA) and subclinical mastitis measured by somatic cell counts (SCC) of quarter milk samples of 239 animals from 3 different breeds and crossbreeds is presented. The statistical analysis is based on a statistical model which includes effects of external and genetic relationship groups (fixed or random) as well as effects of MHC genotypes or alleles. With this model it is possible to estimate unweighted allelic effects of all alleles simultaneously by multiple regression. An analysis of variation in cow average logarithmic SCC indicated no significant random sire effect, no significant influence of BoLA alleles but a significant effect of herds, lactation numbers and breeds. These results are discussed in relation to other investigations of MHC associations in cattle concerning mastitis, bovine leukosis and tick and worm infestations. A general problem of demonstrating significant and/or consistent disease associations from population data is discussed in relation to loci studied, disease parameters studied, experimental design and selection on MHC.
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Hetzel, D.J.S., Stear, M.J., Nicholas, F.W., Mackinnon, M.J. and Brown, S.C. 1988. Parasite resistance and the major histocompatibility system in cattle. Animal Genetics, in press.
Holroyd, R.G. and Stear, M.J. 1985. The role of the bovine leukocyte antigen (BoLA) complex in resistance to tick parasites. In: W.C. Davis, J.N. Shelton and C.W. Weems (Editors), Characterization of the Bovine Immune System and The Genes Regulating Expression of Immunity with Particular Reference to Their Role in Disease Resistance. University of Washington Press, pp 165 – 172.
Kaartinen, L., Ali-Vehmas, T., Larsen, B., Jensen, N.E. and Sandholm, M. 1988. Relation of the bovine M blood group system with growth of Streptococcus agalactia and Staphylococcus aureus in whey. J. Vet. Med. B., 35, 77 – 83.
Klein, J. and Figueroa, F. 1986. Evolution of the major histocompatibility complex. CRC Crit. Rev. Immun., 6, 295 – 386.
Larsen, B., Jensen, N.E., Madsen, P., Nielsen, S.M., Klastrup, 0. and Madsen, P.S. 1985. Association of the M blood group system with bovine mastitis. Anim. Blood Groups Biochem. Genet., 16, 165 – 173.
Lewin, H.A. and Bernoco, D. 1986. Evidence for BoLA-linked resistance and susceptibility to subclinical progression of bovine leukaemia virus infection. Anim. Genet., _17., 197 – 207.
Lewin, H.A., Wu, M.-C., Stewart, J.A. and Nolan, T.J. 1988. Association between BoLA and subclinical bovine leukemia virus infection in a herd of Holstein-Friesian cows. Immunogenetics, 27, 338 – 344.
Oddgeirsson, 0., Simpson, S.P., Morgan, A.L.G., Ross, D.S. and Spooner, R.L. 1988. Relationship between the bovine major histocompatibility complex (BoLA), erythrocyte markers and susceptibility to mastitis in Icelandic cattle. Animal Genetics, 19, 11 – 16.
Oddgeirsson, 0., Simpson, S.P., Morgan, A.L.G., Ross, D.S. and Spooner, R.L. 1988. Relationship between the bovine major histocompatibility complex (BoLA), erythrocyte markers and susceptibility to mastitis in Icelandic cattle. Animal Genetics, 19, 11 – 16.
Solbu, H., Spooner, R.L. and Lie, Ø. 1982. A possible influence of the bovine major histocompatibility complex (BoLA) on mastitis. In: Proceedings of 2nd World Congress on Genetics applied to Livestock Production (Madrid), vol. 7, 368 – 371.
Spooner, R., Morgan, A., Sales, D., Simpson, P., Solbu, H. and Lie, 0. 1988. MHC associations with mastitis. Animal Genetics, 19 suppl. 1, 57 – 58.
Stear, M.J., Nicholas, F.W., Brown, S.C., Tierney, T. and Rudder, T. 1984. The relationship between the bovine major histocompatibility system and faecal worm egg counts. In: J.K. Dineen and P.M. Outteridge (Editors), Immunogenetic Approaches to the Control of Endoparasites with Particular Reference to Parasites of the Sheep. CSIRO, pp. 126 – 136.
Stear, M.J., Dimmock, C.K., Newman, M.J. and Nicholas, F.W. 1988a. BoLA antigens are associated with increased frequency of persistent lymphocytosis in bovine leukaemia virus infected cattle and with increased incidence of antibodies to bovine leukaemia virus. Animal Genetics, 9, 151 – 158.
Stear, M.J., Tierney, T.J., Baldock, F.C., Brown, S.C., Nicholas, F.W. and Rudder, T.H. 1988b. Class I antigens of the bovine major histocompatibility system are weakly associated with variation in faecal worm egg counts in naturally infected cattle. Animal Genetics, 19, 115 – 122.
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© 1989 ECSC,EAEC,Brussels and Luxembourg
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Østergård, H. (1989). Statistical Aspects of Cattle MHC (Bola) and Disease Associations Exemplified by an Investigation of Subclinical Mastitis. In: Improving Genetic Disease Resistance in Farm Animals. Current Topics in Veterinary Medicine and Animal Science, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1057-7_13
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DOI: https://doi.org/10.1007/978-94-009-1057-7_13
Publisher Name: Springer, Dordrecht
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