Improving Genetic Disease Resistance in Farm Animals

1. Front Matter

   Pages i-viii

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2. General Aspects

   1. Front Matter

      Pages 1-1

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   2. Introduction

      • A. J. van der Zijpp

      Pages 3-5

   3. Biological Significance of the MHC

      • R. R. P. de Vries

      Pages 6-12

3. MHC serology and immunology

   1. Front Matter

      Pages 13-13

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   2. The Characterisation and Function of the Bovine MHC

      • R. L. Spooner, R. A. Oliver, E. J. Glass, E. A. Innes

      Pages 15-22

   3. Current Status of SLA Class I And II Serology

      • Birte Kristensen

      Pages 23-32

   4. Ela(Equine Lymphocyte Alloantigens) Serology and Genetics

      • H. Varewyck, Y. Bouquet

      Pages 33-41

   5. The Chicken MHC and its Importance+

      • M. Simonsen, M. Arnul, P. Sørensen

      Pages 42-62

   6. Some Evidence for The Presence of an MHC Analogue in Fish

      • E. Egberts, R. J. M. Stet, P. Kaastrup, C. N. Pourreau, W. B. van Muiswinkel

      Pages 63-71

4. MHC polymorphism by protein chemistry and DNA techniques

   1. Front Matter

      Pages 73-73

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   2. Bola Polymorphism, Biochemical Analysis at the Product Level

      • E. J. Hensen, I. Joosten, A. van de Poel, M. F. Sanders

      Pages 75-80

   3. Comparison of BoLa Class I and Class II Typing Methods and their Application to MHC Function Studies

      • J. L. Williams, P. Brown, E. J. Glass, R. A. Oliver, R. L. Spooner

      Pages 81-90

   4. The Molecular Genetics of the Sla Complex

      • Patrick Chardon

      Pages 91-98

   5. Molecular Anatomy of the Chicken Major Histocompatibilty B Complex

      • Charles Auffray

      Pages 99-103

5. Sessions 4 MHC and disease associations Chairpersons: Dr. M. Vaiman and Dr. S. Lazary

   1. Front Matter

      Pages 105-105

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   2. Possible Influence of the Caprine Leucocyte Antigen (CLA) System on Development of Caprine Arthritis Encephalitis (CAE) in Family and Population Studies

      • G. Ruff, S. Lazary

      Pages 107-114

   3. Statistical Aspects of Cattle MHC (Bola) and Disease Associations Exemplified by an Investigation of Subclinical Mastitis

      • H. Østergård

      Pages 115-123

   4. Possible Effects of the Pig SLA Complex on Physiological Performances

      • Marcel Vaiman

      Pages 124-133

   5. Ela Disease Associations

      • S. Lazary, H. Gerber

      Pages 134-142

This publication contains the proceedings of a seminar held in Brussels on November 8-9, 1988. The title of the seminar was "Reducing the costs of disease by improving resistance through genetics". The seminar was held as an activity of the Community Programme for the Coordination of Agricultural Research, 1984-1988. Costs of disease depend on losses caused by morbidity, mortality and production decreases and on the costs of preventive measures including vaccination and medication. Production losses often contribute a major portion to the total costs. To reduce costs of disease preventive measures like vaccination, preventive medication and hygienic procedures are applied. Genetic resistance is an attractive preventive measure because of its consistent nature in the next generations, because it precludes veterinary services and because there are no side-effects. Constraints are the long term investment, relatively slow progress per generation (in combination with production traits) and the considerable lack of knowledge about inheritance of resistance mechanisms in farm animals.

• anatomy
• animals
• development
• genetics
• system

`It is recommended for libraries and research workers in the field.'
New Zealand Veterinary Journal, September 1990

• Department of Animal Husbandry, Agricultural University, Wageningen, The Netherlands

  A. J. Zijpp

• Reasearch Institute for Animal Production ‘Schoonoord’, Zeist, The Netherlands

  W. Sybesma

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