Abstract
The reactive solvent extraction of olivanic acid MM13902, other beta-lactams and phenoxyacetic acid has been investigated. Extractants were quaternary nitrogen compounds or amine salts, for example tetrabutyl ammonium hydrogen sulphate, Amberlite LA2 hydrochloride, Alamine 336 hydrochloride and Aliquat 336. Solvents included dichloromethane and butyl acetate.
Under appropriate conditions, extractions in excess of 90% could be achieved with all compounds except amoxycillin. Back extraction could be brought about by nitrate and iodide ions, the latter being more effective but more expensive. With nitrate, several extractions were sometimes required to give satisfactory yields.
Small differences in lipophilicity and hence extracting power, for example between Alamine 336 hydrochloride and Aliquat 336, suggest the possibility of selective extraction.
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References
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Harris, T.A.J., Khan, S., Reuben, B.G., Shokoya, T. (1990). Reactive Solvent Extraction of Beta-Lactam Antibiotics. In: Pyle, D.L. (eds) Separations for Biotechnology 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0783-6_19
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DOI: https://doi.org/10.1007/978-94-009-0783-6_19
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