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Separations for Biotechnology 2

  • Book
  • © 1990

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Editors:
  1. D. L. Pyle

    1. Biotechnology Group, University of Reading, UK

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Table of contents (68 chapters)

  1. Front Matter

    Pages i-xii
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  3. Cell Disruption and Removal of Insolubles

    1. Front Matter

      Pages 9-9
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    2. Cell Disruption and Removal of Insolubles

      • J. A. Asenjo
      Pages 11-20

    3. Differential Product Release from Yeast Cells by Selective Enzymatic Lysis

      • B. A. Andrews, R.-B. Huang, J. A. Asenjo
      Pages 21-28

    4. Conceptual Design of a Novel Flocculation Device

      • M. H. J. Ashley
      Pages 29-37

    5. The Effect of Culture History on the Disruption of Alcaligenes Eutrophus by High Pressure Homogenisation

      • Susan T. Harrison, John S. Dennis, Howard A. Chase
      Pages 38-47

    6. Separation by Biopolymer Separation of Suspended Solid by Microbial Flocculant

      • Ryuichiro Kurane
      Pages 48-54

    7. Protein Release from the Yeast Pichia Pastoris by Chemical Permeabilization: Comparison to Mechanical Disruption and Enzymatic Lysis

      • Thomas J. Naglak, Henry Y. Wang
      Pages 55-64

    8. The Concentration of Yeast Suspensions by Crossflow Filtration

      • M. Pritchard, J. A. Scott, J. A. Howell
      Pages 65-73

    9. Heterologous Flocculation of Escherichia Coli and Yeast

      • R. G. Protheroe, R. H. Cumming, A. J. Matchett
      Pages 74-82

    10. Lateral Migration: A laminar fluid flow mechanism suited to Biotechnology separations

      • G. J. Purdom, C. A. Lambe
      Pages 83-92

    11. The Dewatering of Biological Suspensions in Industrial Centrifuges

      • P. N. Ward, M. Hoare
      Pages 93-101

  4. Concentration Processes

    1. Front Matter

      Pages 103-103
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    2. Concentration and Selectivity in Bioseparations

      • D. L. Pyle
      Pages 105-111

    3. A Model for Emulsion Liquid Membrane Extraction of Organic Acids

      • J. B. Chaudhuri, D. L. Pyle
      Pages 112-121

    4. Vortex Flow Filtration for Ultrafiltration of Protein Solutions

      • Charles L. Cooney, Ulrich Holeschovsky, Gopal Agarwal
      Pages 122-131

    5. Membrane Filtration: A Priori Predictions of the Ideal Limiting Flux

      • Robert Field
      Pages 132-141

    6. Clarification of Tissue Culture Fluid and Cell Lysates Using Biocryl® Bioprocessing Aids

      • Kathleen Fletcher, Sheryl Deley, Robert J. Fleischaker Jr, Ian T. Forrester, Anthony C. Grabski, W. Nick Strickland
      Pages 142-151
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Keywords

About this book

The challenge of bioseparations is to isolate and purify identified products from the dilute product broth produced from cell culture. Innovation in bioseparations technology is increasingly driven by the requirements imposed by the growing importance of production on a process scale of injectable-grade products, and economic pressures to improve the efficiency of downstream processing. As in other areas of technical change, science does not necessarily precede new technology: progress results from a complex and messy mixture of advances in understanding, ingenious ideas, novel techniques and chance discoveries. What is certain is that close interaction between academics and practitioners, biological scientists and process engineers is needed to solve the problems of bioseparations. The Second International Conference on Separations for Biotechnology at Reading, UK, in September 1990 set out to provide a critical multidisciplinary forum for the discussion of bioseparations. This volume contains the papers presented at the meeting. The meeting was organised around six themes with oral and poster presentations on the science and practice of bioseparations technology, and the same structure has been kept for this book. We have also included the texts of the keynote review paper by Professor Alan Michaels and the introductory review papers specially commissioned for the conference. Within each part of this book the review paper is followed by the contributed papers grouped alphabetically by their first author. All the original papers published here were accepted for publication after scientific refereeing.

Editors and Affiliations

  • Biotechnology Group, University of Reading, UK

    D. L. Pyle

Bibliographic Information

  • Book Title: Separations for Biotechnology 2

  • Editors: D. L. Pyle

  • DOI: https://doi.org/10.1007/978-94-009-0783-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: SCI 1990

  • Hardcover ISBN: 978-1-85166-545-7Due: 30 September 1990

  • Softcover ISBN: 978-94-010-6839-0Published: 17 October 2011

  • eBook ISBN: 978-94-009-0783-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 658

  • Topics: Animal Anatomy / Morphology / Histology, Biotechnology

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