Skip to main content
SpringerLink
Log in

Genetics

  • Chapter
  • First Online:
Autoimmune Disease

Part of the book series: SpringerBriefs in Public Health ((BRIEFSPUBLIC))

  • 1112 Accesses

Abstract

Studies of families, including twins, show that autoimmune diseases are weakly inherited, with disease specificity, the Mendelian pattern being that of causation by multiple, co-dominant (expressed in the heterozygous state) genes with incomplete penetrance [1]. What genes are these? Before discussing this we need to describe the histocompatibility system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Adams DD, Knight JG. Principles of autoimmune disease: pathogenesis, genetics and specific immunotherapy. J Clin Lab Immunol. 2003;52:1–22.

    PubMed  CAS  Google Scholar 

  2. Klein J. Biology of the mouse histocompatibility-2 complex. Berlin: Springer; 1975.

    Book  Google Scholar 

  3. Haldane JBS. The genetics of cancer. Nature. 1933;132:265–7.

    Article  Google Scholar 

  4. Dausset J, Svejgaard A. HLA and disease. Copenhagen: Munksgaard; 1977.

    Google Scholar 

  5. McKusick VA. Mendelian inheritance in man. 5th ed. Baltimore: Johns Hopkins University Press; 1978.

    Google Scholar 

  6. Vladutiu AO, Rose NR. Autoimmune mouse thyroiditis. Relation to histicompatibility type. Science. 1972;174:1137–8.

    Article  Google Scholar 

  7. Schlosstein L, Terasaki PI, Bluestone R, Pearson GM. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973;288:704–6.

    Article  PubMed  CAS  Google Scholar 

  8. Tiwari JL, Terasaki PI. HLA and disease associations. New York: Springer; 1985.

    Book  Google Scholar 

  9. Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogeneic system. Nature. 1974;248:701–2.

    Article  PubMed  CAS  Google Scholar 

  10. Adams DD. Protection from autoimmune disease as the third function of the major histocompatibility gene complex. Lancet. 1987; ii: 245–9.

    Google Scholar 

  11. Fenner F, White DO. Medical virology. London: Academic Press; 1975

    Google Scholar 

  12. Simonsen N. On the nature and measurement of antigenic strength. Transplant Rev. 1970;3:22–35.

    Google Scholar 

  13. Benacerraf B, McDevitt HO. The histocompatibility-linked immune response genes. Science. 1972;175:273–9.

    Article  PubMed  CAS  Google Scholar 

  14. Bielschowsky M, Helyer BJ, Howie JB. Spontaneous haemolytic anaemia in mice of the NZB/BL strain. Proc Univ Otago Med Sch. 1959;37:9–11.

    Google Scholar 

  15. Howie JB, Helyer BJ. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–66.

    Article  PubMed  CAS  Google Scholar 

  16. Knight JG, Adams DD. Three genes for lupus nephritis in NZB × NZW mice. J Exp Med. 1978;147:1653–60.

    Article  PubMed  CAS  Google Scholar 

  17. Drake CG, Babcock SK, Palmer E, Kotzin EL. Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB × NZW) F1 mice. Proc Natl Acad Sci USA. 1994;91:4062–6.

    Article  PubMed  CAS  Google Scholar 

  18. Kono DH, Burlingame RW, Owen DG, Kuramochi A, Dalderas RS, Balomenos, D, Theofilopoulos, AN. Lupus susceptibility loci in New Zealand mice. Proc Natl Acad Sci USA 1994; 91:10168–72sss.

    Google Scholar 

  19. Knight JG, Adams DD. Genes determining autoimmune disease in New Zealand mice. J Clin Lab Immunol. 1981;5:165–70.

    PubMed  CAS  Google Scholar 

  20. Einstein A. Essays in science. New York: Philosophical Library Inc; 1934. p. 92.

    Google Scholar 

  21. Auchincloss H, Sykes M, Sachs DH. Transplantation immunology. In: Paul WE, editor. Fundamental immunology. 4th ed. Philadelphia: Lippincott-Raven; 1999. p. 1175–235.

    Google Scholar 

  22. Adams DD, Knight JG. The H gene theory of inherited autoimmune disease. Lancet. 1980; i:396–8.

    Google Scholar 

  23. Knight JG, Adams DD. The genetic basis of autoimmune disease. Ciba Found Symp. 1982;90:35–56.

    PubMed  Google Scholar 

  24. Snell GD. The H2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol (Praha). 1968; 14:335–8.

    Google Scholar 

  25. Knight JG. Dopamine receptor-stimulating autoantibodies: a possible cause of schizophrenia. Lancet. 1982; ii:1073–6.

    Google Scholar 

  26. Knight JG, Knight A, Pert CB. Is schizophrenia a virally-triggered anti-receptor autoimmune disease? In: Helmchen H, Henn FA, editors. Biological perspectives of Schizophrenia. New York: Wiley; 1987. p. 107–27.

    Google Scholar 

  27. Kety SS. Mental illness in the biological and adoptive relatives of schizophrenic adoptees: findings relevant to genetic and environmental factors in etiology. Am J Psych. 1983;140:720–7.

    CAS  Google Scholar 

  28. Mellsop GW, Koadlow L, Syme J, Whittingham S. Absence of rheumatoid arthritis in schizophrenia. Aust N Z J Med. 1974;4:247–52.

    Article  PubMed  CAS  Google Scholar 

  29. Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 2003;361:417–9.

    Google Scholar 

  30. Gelder M, Gath D, Mayou R, Cowan P. Oxford Textbook of Psychiatry. 3rd ed. Oxford: Oxford University Press. 1998. p. 74–104.

    Google Scholar 

  31. Adams DD, Knight JG, Manning P, Smith G. An informative case of Graves’ disease with implications for schizophrenia. J Clin Lab Immunol 2005;53:13–25.

    Google Scholar 

  32. Knight JG, Menkies DB, Highton J, Adams DD. Rationale for a trial of immunosuppressive therapy in acute schizophrenia. Molecular Psychiatry. 2007;12:421–31.

    Article  Google Scholar 

  33. Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. (eds) Harrison’s Principles of Internal Medicine 16th ed. New York: McGraw-Hill, 2005.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Medicine, University of Otago, Cumberland Street 720, Dunedin, New Zealand

    Duncan Dartrey Adams

  2. Analogue Digital Instruments, 713 Kaikorai Valley Rd, 9010, Dunedin, New Zealand

    Christopher Dartrey Adams

Authors
  1. Duncan Dartrey Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christopher Dartrey Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Duncan Dartrey Adams .

Rights and permissions

Reprints and permissions

Copyright information

© 2013 The Author(s)

About this chapter

Cite this chapter

Adams, D.D., Adams, C.D. (2013). Genetics. In: Autoimmune Disease. SpringerBriefs in Public Health. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6937-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-6937-3_3

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-6936-6

  • Online ISBN: 978-94-007-6937-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation