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Lacrimal Gland Regeneration: Progress and Promise

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Regenerative Medicine

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Abstract

The lacrimal gland is a tubuloacinar gland located in the groove of the frontal bone, which is involved in synthesis and secretion of major tear proteins and other aqueous components of the trilayered tear film. Any injury to the lacrimal gland, which may be age related, drug or radiation therapy induced leads to dysfunction of the gland with a resultant hyperosmolarity of the tear film and its subsequent instability. This tear film instability leads to destabilization of the ocular surface homeostasis and to a number of morbid complications like the dry eye syndrome.

The current treatment modality for chronic dry eye remains palliative, which provides only temporary symptomatic relief. One of the modalities of providing long-term benefit to these patients would be cell therapy to restore or replenish the damaged gland. This review describes the progress and promise of cell therapy for lacrimal gland regeneration for potential clinical application.

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Acknowledgements

The authors wish to thank the patients who donated their exenterated tissue for research, the surgical oncology team of Dr Santosh G. Honavar, Dr Milind N.Naik, Dr Javed Ali and Dr Vijay Anand Reddy. We also thank the Director of Research, LVPEI, Dr D. Balasubramanian, for his constant support and encouragement.

Method of literature search

A search of Pubmed database (1979–till date) was conducted. Medline, Elsevier-EMBASE and Ophthalmic literature databases was also searched. The following key words were used: Lacrimal gland/lacrimal in-vitro studies/dry eye syndrome.

Additional sources include review of publications cited in other articles. Google search was also used to find publication that may be missed in the above databases.

Funding Agencies: International Atomic Energy Agency (IAEA), Department of Biotechnology (DBT), Hyderabad Eye Research Foundation (HERF), Champalimaud Translational Research Centre (C- Tracer), Sudhakar and Sreekanth Ravi Brothers

Financial Disclosure: None

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Authors and Affiliations

  1. Sudhakar and Sreekant Ravi Stem Cell Biology Laboratory, Prof Brien Holden Research Centre, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, L.V. Prasad Marg, Hyderabad, 500 034, Andhra Pradesh, India

    Shubha Tiwari M.Pharm.

  2. School of Medical Sciences, University of Hyderabad, Prof C R Rao Road, Gachibowli, Hyderabad, 500 046, Andhra Pradesh, India

    Geeta K. Vemuganti M.D., DNB, FAMS, FICP

Authors
  1. Shubha Tiwari M.Pharm.
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  2. Geeta K. Vemuganti M.D., DNB, FAMS, FICP
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Corresponding author

Correspondence to Geeta K. Vemuganti M.D., DNB, FAMS, FICP .

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Editors and Affiliations

  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Tiwari, S., Vemuganti, G.K. (2013). Lacrimal Gland Regeneration: Progress and Promise. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5690-8_30

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