Skip to main content
SpringerLink
Log in

Extracellular Matrix and Tissue Regeneration

  • Chapter
  • First Online:
Regenerative Medicine

  • 2313 Accesses

Abstract

Extracellular matrix (ECM) is an important component of stem cell niche areas, which provide residence, regulate stem cell pool size and control stem cell mobilization. ECM is a complex interlinked composite of collagenous molecules, non-collagenous molecules and water-rich mucopolysaccharide ground substance. Cells are integrated to their matrix via integrin and non-integrin receptors, which are utilized in the control of adhesion, migration, division, growth, anoikis, transdifferentiation and other cellular behaviour. ECM provides architecture and strength, but also growth factor deposits, which proteinases as signalling scissors can release in a site- and process-specific manner. Several processes, like wounds, cartilage, fractures, myocardial infarctions and tumor growth are used to exemplify regenerative processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ågren MS, Werthén M (2007) The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds. Int J Low Extrem Wounds 6:82–97

    Article  PubMed  Google Scholar 

  • Ågren MS, Eaglstein WH, Ferguson MW, Harding KG, Moore K, Saarialho-Kere UK, Schultz GS (2000) Causes and effects of the chronic inflammation in venous leg ulcers. Acta Derm Venereol Suppl 210:3–17

    Google Scholar 

  • Alford JW, Cole BJ (2005) Cartilage restoration, part 1: basic science, historical perspective, patient evaluation, and treatment options. Am J Sports Med 33:295–306

    Article  PubMed  Google Scholar 

  • Allemann F, Mizuno S, Eid K, Yates KE, Zaleske D, Glowacki J (2001) Effects of hyaluronan on engineered articular cartilage extracellular matrix gene expression in 3-dimensional collagen scaffolds. J Biomed Mater Res 55:13–19

    Article  PubMed  CAS  Google Scholar 

  • Alsalameh S, Amin R, Gemba T, Lotz M (2004) Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 50:1522–1532

    Article  PubMed  Google Scholar 

  • Amalinei C, Caruntu I-D, Balan RA (2007) Biology of metalloproteinases. Rom J Morphol Embryol 48:323–334

    PubMed  Google Scholar 

  • Angata T, Brinkman-van der Linden ECM (2002) I-type lectins. Biochim Biophys Acta 1572:294–316

    Article  PubMed  CAS  Google Scholar 

  • Arikawa T, Matsukawa A, Watanabe K, Sakata KM, Seki M, Nagayama M, Takeshita K, Ito K, Niki T, Oomizu S, Shinonaga R, Saita N, Hirashima M (2009) Galectin-9 accelerates transforming growth factor beta3-induced differentiation of human mesenchymal stem cells to chondrocytes. Bone 44:849–857

    Article  PubMed  CAS  Google Scholar 

  • Askari A, Brennan ML, Zhou X, Drinko J, Morehead A, Thomas JT, Topol EJ, Hazen SL, Penn MS (2003) Myeloperoxidase and plasminogen activator inhibitor-1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med 197:615–624

    Article  PubMed  CAS  Google Scholar 

  • Aszódi A, Legate KR, Nakchbandi I, Fässler R (2006) What mouse mutants teach us about extracellular matrix function. Annu Rev Cell Dev Biol 22:591–621

    Article  PubMed  CAS  Google Scholar 

  • Aumailley M, Bruckner-Tuderman L, Carter WG et al (2005) A simplified laminin nomenclature. Mini review. Matrix Biol 24:326–332

    Article  PubMed  CAS  Google Scholar 

  • Badylak SF (2002) The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol 13:377–383

    Article  PubMed  CAS  Google Scholar 

  • Bani D, Nistri S, Formigli L, Meacci E, Francini F, Zecchi-Orlandini S (2009) Prominent role of relaxin in improving postinfarction heart remodeling. Clues from in vivo and in vitro studies with genetically engineered relaxin-producing myoblasts. Ann N Y Acad Sci 1160:269–277

    Article  PubMed  CAS  Google Scholar 

  • Battiwalla M, Hematti P (2009) Mesenchymal stem cells in hematopoietic stem cell transplantation. Cytotherapy 11:503–515

    Article  PubMed  Google Scholar 

  • Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC (2009) Syndecan-1 regulates αVβ3 and αvβ5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med 206:691–705

    Article  PubMed  CAS  Google Scholar 

  • Bernfield M, Kokenyesi R, Kato M, Hinkes MT, Spring J, Gallo RL, Lose EJ (1992) Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. Ann Rev Biol 8:365–393

    Article  CAS  Google Scholar 

  • Borza DB, Bondar O, Ninomiya Y, Sado Y, Naito I, Todd P, Hudson BG (2001) The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes. J Biol Chem 276:28532–28540

    Article  PubMed  CAS  Google Scholar 

  • Boutaud A, Borza DB, Bondar O, Gunwar S, Netzer KO, Singh N, Ninomiya Y, Sado Y, Noelken ME, Hudson BG (2000) Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains. J Biol Chem 275:30716–30724

    Article  PubMed  CAS  Google Scholar 

  • Brody S, Pandit A (2007) Approaches to heart valve tissue engineering scaffold design. J Biomed Mater Res Part B Appl Biomater 83:16–43

    Article  PubMed  CAS  Google Scholar 

  • Brooks PC, Clark RAF, Cheresh DA (1994) Requirement of vascular integrin αVβ3 for angiogenesis. Science 264:569–571

    Article  PubMed  CAS  Google Scholar 

  • Bullard KM, Longaker MT, Lorenz HP (2003) Fetal wound healing: current biology. World J Surg 27:54–61

    Article  PubMed  Google Scholar 

  • Canty EG, Kadler KE (2005) Procollagen trafficking, processing and fibrillogenesis. J Cell Sci 118:1341–1353

    Article  PubMed  CAS  Google Scholar 

  • Capito RM, Spector M (2003) Scaffold-based articular cartilage repair. IEEE Eng Med Biol Mag Q Mag Eng Med Biol Soc 22:42–50

    Article  Google Scholar 

  • Clark RAF (1995) Wound repair: overview and general considerations. In: The molecular and cellular biology of wound repair, 2nd edn. Plenum Press, New York, pp 513–560

    Google Scholar 

  • Cosgrove D, Meehan DT, Grunkemeyer JA, Kornak JM, Sayers R, Hunter WJ, Samuelson GC (1996) Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev 10:2981–2992

    Article  PubMed  CAS  Google Scholar 

  • Coussens LM, Fingleton B, Matrisian LM (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295:2387–2392

    Article  PubMed  CAS  Google Scholar 

  • Creemers EE, Cleutjens JP, Smits JF, Daemen MJ (2001) Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circ Res 89:201–210

    Article  PubMed  CAS  Google Scholar 

  • Crisostomo PR, Markel TA, Wang Y, Meldrum DR (2008) Surgically relevant aspects of stem cell paracrine effects. Surgery 143:577–581

    Article  PubMed  Google Scholar 

  • Cui F-Z, Li Y, Ge J (2007) Self-assembly of mineralized collagen composites. Mater Sci Eng R 57:1–27

    Article  CAS  Google Scholar 

  • Davis GE, Senger DR (2005) Endothelial extracellular matrix. Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res 97:1093–1107

    Article  PubMed  CAS  Google Scholar 

  • Deten A, Holzl A, Leicht M, Barth W, Zimmer HG (2001) Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats. J Mol Cell Cardiol 33:1191–1207

    Article  PubMed  CAS  Google Scholar 

  • Deten A, Volz HC, Briest W, Zimmer HG (2002) Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. Cardiovasc Res 55:329–340

    Article  PubMed  CAS  Google Scholar 

  • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL (2003) Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 5:410–421

    Article  PubMed  CAS  Google Scholar 

  • Docheva D, Popov C, Mutschler W, Schieker M (2007) Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system. J Cell Mol Med 11:21–38

    Article  PubMed  CAS  Google Scholar 

  • Doe CQ, Bowerman B (2001) Asymmetric cell division: fly neuroblast meets worm zygote. Curr Opin Cell Biol 13:68–75

    Article  PubMed  CAS  Google Scholar 

  • East L, Isacke CM (2002) The mannose receptor family. Biochim Biophys Acta 1572:364–386

    Article  PubMed  CAS  Google Scholar 

  • Eckes B, Kessler D, Aumailley M, Krieg T (1999) Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis. Springer Semin Immunopathol 21:415–429

    Article  PubMed  CAS  Google Scholar 

  • Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161–174

    Article  PubMed  CAS  Google Scholar 

  • Egles C, Claudepierre T, Manglapus MK, Champliaud MF, Brunken WJ, Hunter DD (2007) Laminins containing the beta2 chain modulate the precise organization of CNS synapses. Mol Cell Neurosci 34:388–398

    Article  CAS  Google Scholar 

  • Ekblom P, Lonai P, Talts JF (2003) Expression and biological role of laminin-1. Matrix Biol J Int Soc Matrix Biol 22:35–47

    Article  CAS  Google Scholar 

  • Eklund L, Piuhola J, Komulainen J, Sormunen R, Ongvarrasopone C, Fássler R, Muona A, Ilves M, Ruskoaho H, Takala TE, Pihlajaniemi T (2001) Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A 98:1194–1199

    Article  PubMed  CAS  Google Scholar 

  • Ellis SJ, Tanantzapf G (2010) Integrin-mediated adhesion and stem-cell-niche interactions. Cell Tissue Res 339:121–130

    Google Scholar 

  • Engler AJ, Sen S, Sweeney HL, Discher DE (2006) Matrix elasticity directs stem cell lineage specification. Cell 126:677–689

    Article  PubMed  CAS  Google Scholar 

  • Fanjul-Fernández M, Folgueras AR, Cabrera S, López-Otin C (2010) Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochim Biophys Acta 1803:3–19

    Google Scholar 

  • Fawcett JW, Asher RA (1999) The glial scar and central nervous system repair. Brain Res Bull 49:377–391

    Article  PubMed  CAS  Google Scholar 

  • Fortier LA, Mohammed HO, Lust G, Nixon AJ (2002) Insulin-like growth factor-I enhances cell-based repair of articular cartilage. J Bone Jt Surg Br Vol 84-B:276–288

    Article  Google Scholar 

  • Fox JW, Mayer U, Nischt R, Aumailley M, Reinhardt D, Wiedemann H, Mann K, Timpl R, Krieg T, Engel J, Chu M-L (1991) Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen type IV. EMBO J 10:3137–3146

    PubMed  CAS  Google Scholar 

  • Fox JM, Ghamberlain G, Ashton BA, Middleton J (2007) Recent advances into the understanding of mesenchymal stem cell trafficking. Br J Haematol 137:491–502

    Article  PubMed  CAS  Google Scholar 

  • Fukai N, Eklund L, Marneros AG, Oh SP, Keene DR, Tamarkin L, Niemelä M, Ilves M, Li E, Pihlajaniemi T, Olsen BR (2002) Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J 21:1535–1544

    Article  PubMed  CAS  Google Scholar 

  • Getgood A, Brooks R, Fortier L, Rushton N (2009) Articular cartilage tissue engineering: today’s research, tomorrow’s practice? J Bone Jt Surg Br Vol 91:565–576

    Article  CAS  Google Scholar 

  • Glowacki J, Mizuno S (2007) Collagen scaffolds for tissue engineering. Biopolymers 89:338–344

    Article  CAS  Google Scholar 

  • Gohring W, Sasaki T, Heldin CH, Timpl R (1998) Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope. Eur J Biochem 255:60–66

    Article  PubMed  CAS  Google Scholar 

  • Gray H, Bannister LH, Berry MM, Williams PL (1995) Gray’s anatomy: the anatomical basis of medicine and surgery. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Gronthos S, Simmons PJ, Graves SE, Robey PG (2001) Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28:174–181

    Article  PubMed  CAS  Google Scholar 

  • Guo T, Zhao J, Chang J, Ding Z, Hong H, Chen J, Zhang J (2006) Porous chitosan-gelatin scaffold containing plasmid DNA encoding transforming growth factor-beta1 for chondrocytes proliferation. Biomaterials 27:1095–1103

    Article  PubMed  CAS  Google Scholar 

  • Hayes AJ, Tudor D, Nowell MA, Caterson B, Hughes CE (2008) Chondroitin sulphate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. J Histochem Cytochem 56:125–138

    Article  PubMed  CAS  Google Scholar 

  • Heino J (2007) The collagen family members as cell adhesion proteins. BioEssays News Rev Mol Cell Dev Biol 29:1001–1010

    Article  CAS  Google Scholar 

  • Heino J, Käpylä J (2009) Cellular receptors of extracellular matrix molecules. Curr Pharm Des 15:1309–1317

    Article  PubMed  CAS  Google Scholar 

  • Heinola T, Kouri V-P, Clarijs P, Ciferska H, Sukura A, Salo J, Konttinen YT (2010) High mobility group box-1 (HMGB-1) in osteoarthritic cartilage. Clin Exp Rheumatol 28:511–518

    PubMed  CAS  Google Scholar 

  • Herrick SE, Sloan P, McGurk M, Freak L, McCollum CN, Ferguson MW (1992) Sequential changes in histologic pattern and extracellular matrix deposition during the healing or chronic venous ulcers. Am J Pathol 141:1085–1095

    PubMed  CAS  Google Scholar 

  • Herrick SE, Ireland GW, Simon D, McCollum CN, Ferguson MW (1996) Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions. J Investig Dermatol 106:187–193

    Article  PubMed  CAS  Google Scholar 

  • Hodde JP, Johnson CE (2007) Extracellular matrix as a strategy for treating chronic wounds. Am J Clin Dermatol 8:61–66

    Article  PubMed  Google Scholar 

  • Hoemann CD, Sun J, McKee MD, Chevrier A, Rossomacha E, Rivard GE, Hurtig M, Buschmann MD (2007) Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. Osteoarthr Cartil 15:78–89

    Article  PubMed  CAS  Google Scholar 

  • Hudson BG (2004) The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. J Am Soc Nephrol 15:2514–2527

    Article  PubMed  Google Scholar 

  • Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003) Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. N Engl J Med 348:2543–2556

    Article  PubMed  CAS  Google Scholar 

  • Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529–2543

    Article  PubMed  CAS  Google Scholar 

  • Hutmacher DW, Kirsch A, Ackermann KL, Huerzeler MB (1998) Matrix and carrier materials for bone growth factors – state of the art and future perspectives. In: Stark GB, Horch R, Tancos E (eds) Biological matrices and tissue reconstruction. Springer, Heidelberg, pp 197–206

    Chapter  Google Scholar 

  • Hwang MW, Matsumori A, Furukawa Y, Ono K, Okada M, Iwasaki A, Hara M, Miyamoto T, Touma M, Sasayama S (2001) Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling. J Am Coll Cardiol 38:1546–1553

    Article  PubMed  CAS  Google Scholar 

  • Imanaka-Yoshida K, Hiroe M, Nishikawa T, Ishiyama S, Shimojo T, Ohta Y, Sakakura T, Yoshida T (2001) Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction. Lab Investig J Tech Methods Pathol 81:1015–1024

    Article  CAS  Google Scholar 

  • Ip JE, Wu Y, Huang J, Zhang L, Pratt RE, Dzau VJ (2007) Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell 18:2873–2882

    Article  PubMed  CAS  Google Scholar 

  • Irwin CR, Myrillas T, Smyth M, Doogan J, Rice C, Schor SL (1998) Regulation of fibroblast-induced collagen gel contraction by interleukin-1b. J Oral Pathol Med 27:255–259

    CAS  Google Scholar 

  • Iwakura A, Shastry S, Luedemann C, Hamada H, Kawamoto A, Kishore R, Zhu Y, Qin G, Silver M, Thorne T, Eaton L, Masuda H, Asahara T, Losordo DW (2006) Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 113:1605–1614

    Article  PubMed  CAS  Google Scholar 

  • Jäälinoja J (2007) The structure and function of normal and mutated collagen IX. Thesis work. Oulu University Press, Oulu

    Google Scholar 

  • Jones JC, Dehart GW, Gonzales M, Goldfinger LE (2000) Laminins: an overview. Microsc Res Tech 51:211–213

    Article  PubMed  CAS  Google Scholar 

  • Juncosa-Melvin N, Shearn JT, Boivin GP, Gooch C, Galloway MT, West JR, Nirmalanandhan VS, Bradica G, Butler DL (2006) Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair. Tissue Eng 12:2291–2300

    Article  PubMed  CAS  Google Scholar 

  • Kalluri R (2003) Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3:422–433

    Article  PubMed  CAS  Google Scholar 

  • Karadag A, Fisher LW (2006) Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to alpha(v)beta3-integrin. J Bone Miner Res 21:1627–1636

    Article  PubMed  CAS  Google Scholar 

  • Kato Y, Nishikawa T, Kawakishi S (1995) Antioxidative activity of tetrahydrocurcuminoids. Photochem Photobiol 61:367–372

    Article  PubMed  CAS  Google Scholar 

  • Katsuragi N, Morishita R, Nakamura N, Ochiai T, Taniyama Y, Hasegawa Y, Kawashima K, Kaneda Y, Ogihara T, Sugimura K (2004) Periostin as a novel factor responsible for ventricular dilation. Circulation 110:1806–1813

    Article  PubMed  CAS  Google Scholar 

  • Keating A (2012) Mesenchymal stromal cells: new directions. Cell Stem Cell 10:706–716

    Article  CAS  Google Scholar 

  • Kefalides NA (1966) A collagen of unusual composition and a glycoprotein isolated from canine glomerular basement membrane. Biochem Biophys Res Commun 22:26–32

    Article  PubMed  CAS  Google Scholar 

  • Khang D, Park GE, Webster TJ (2008) Enhanced chondrocyte densities on carbon nanotube composites: the combined role of nanosurface roughness and electrical stimulation. J Biomed Mater Res Part A 86-A:253–260

    Article  CAS  Google Scholar 

  • Khoshnoodi J, Pedchenko V, Hudson BG (2008) Mammalian collagen IV. Microsc Res Tech 71:357–370

    Article  PubMed  CAS  Google Scholar 

  • Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002) Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. J Biol Chem 277:44864–44869

    Article  PubMed  CAS  Google Scholar 

  • Kleinman HK, Klebe RJ, Martin GR (1981) Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol 88:473–485

    Article  PubMed  CAS  Google Scholar 

  • Knudson W, Casey B, Nishida Y, Eger W, Kuettner KE, Knudson CB (2000) Hyaluronan oligosacchrarides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis Rheum 43:1165–1174

    Article  PubMed  CAS  Google Scholar 

  • Ko GJ, Kang YS, Han SY, Lee MH, Song HK, Han KH, Kim HK, Han JY, Cha DR (2008) Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrol Dial Transplant 23:2750–2760

    Article  PubMed  CAS  Google Scholar 

  • Koenig A, Mueller C, Hasel C, Adler G, Menke A (2006) Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Res 66(9):4662–4671

    Article  PubMed  CAS  Google Scholar 

  • Kohfeldt E, Sasaki T, Gohring W, Timpl R (1998) Nidogen-2: a new basement membrane protein with diverse binding properties. J Mol Biol 282:99–109

    Article  PubMed  CAS  Google Scholar 

  • Kuhn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT (2007) Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med 13:962–969

    Article  PubMed  CAS  Google Scholar 

  • Kuo CK, Tuan RS (2008) Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A 14:1615–1627

    Article  PubMed  CAS  Google Scholar 

  • Kvist AP, Latvanlehto A, Sund M, Eklund L, Väisänen T, Hägg P, Sormunen R, Komulainen J, Fässler R, Pihlajaniemi T (2001) Lack of cytosolic and transmembrane domains of type XIII collagen results in progressive myopathy. Am J Pathol 159:1581–1592

    Article  PubMed  CAS  Google Scholar 

  • Laflamme MA (2007) Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 25:1015–1024

    Article  PubMed  CAS  Google Scholar 

  • Laflamme MA, Murry CE (2005) Regenerating the heart. Nat Biotechnol 23:845–856

    Article  PubMed  CAS  Google Scholar 

  • Laine M, Virtanen I, Salo T, Konttinen YT (2004) Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjögren’s syndrome. Arthritis Rheum 50:3968–3973

    Article  PubMed  CAS  Google Scholar 

  • Laine M, Virtanen I, Porola P, Rotar Z, Rozman B, Poduval P, Konttinen YT (2008) Acinar epithelial cell laminin-receptors in labial salivary glands in Sjögren’s syndrome. Clin Exp Rheumatol 26:807–813

    PubMed  CAS  Google Scholar 

  • Laurens N, Engelse MA, Jungerius C, Löwik CW, van Hinsbergh VWM, Koolwijk P (2009) Single and combined effects of avb3- and a5b1-integrins on capillary tube formation in a human fibrinous matrix. Angiogenesis 12:275–285

    Article  PubMed  CAS  Google Scholar 

  • Leitinger B, Hohenester E (2007) Mammalian collagen receptors. Matrix Biol J Int Soc Matrix Biol 26:146–155

    Article  CAS  Google Scholar 

  • Li S, Liquari P, McKee KK, Harrison D, Patel R, Lee S, Yurchenco PD (2005a) Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts. J Cell Biol 169:179–189

    Article  PubMed  CAS  Google Scholar 

  • Li WJ, Tuli R, Huang X, Laquerriere P, Tuan RS (2005b) Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 26:5158–5166

    Article  PubMed  CAS  Google Scholar 

  • Li G, Zhang XA, Wang H, Wang X, Meng CL, Chan CY, Yew DT, Tsang KS, Li K, Tsai SN, Ngai SM, Han ZC, Lin MC, He ML, Kung HF (2009) Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: implication in the migration. Proteomics 9:20–30

    Article  PubMed  CAS  Google Scholar 

  • Litvin J, Blagg A, Mu A, Matiwala S, Montgomery M, Berretta R, Houser S, Margulies K (2006) Periostin and periostin-like factor in the human heart: possible therapeutic targets. Cardiovas Pathol Off J Soc Cardiovasc Pathol 15:24–32

    Article  CAS  Google Scholar 

  • Lu L, Zhu X, Valenzuela RG, Currier BL, Yaszemski MJ (2001) Biodegradable polymer scaffolds for cartilage tissue engineering. Clin Orthop Relat Res 391(Suppl):S251–S270

    Article  PubMed  Google Scholar 

  • Ma GF, Ali A, Verzijl N, Hanemaaijer R, TeKoppele J, Konttinen YT, Salo J (2006) Increased collagen degradation around loosened total hip replacement implants. Arthritis Rheum 54:2928–2933

    Article  PubMed  Google Scholar 

  • Maeshima Y, Yerramalla UL, Dhanabal M, Holthaus KA, Barbashov S, Kharbanda S, Reimer C, Manfredi M, Dickerson WM, Kalluri R (2001) Extracellular matrix-derived peptide binds to alpha(v)beta(3) integrin and inhibits angiogenesis. J Biol Chem 276:31959–31968

    Article  PubMed  CAS  Google Scholar 

  • Maeshima Y, Sudhakar A, Lively JC, Ueki K, Kharbanda S, Kahn CR, Sonenberg N, Hynes RO, Kalluri R (2002) Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 295:140–143

    Article  PubMed  CAS  Google Scholar 

  • Maitra N, Flink IL, Bahl JJ, Morkin E (2000) Expression of α and β integrins during terminal differentiation of cardiomyocytes. Cardiovasc Res 47:715–725

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Lemus LA, Wu X, Wilson E, Hill MA, Davis GE, Davis MJ, Meininger GA (2003) Integrins as unique receptors for vascular control. J Vasc Res 40:211–233

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Pomares L, Wienke D, Stillion R, McKenzie EJ, Arnold JN, Harris J, McGreal E, Sim RB, Isacke CM, Gordon S (2006) Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. Eur J Immunol 36:1074–1082

    Article  PubMed  CAS  Google Scholar 

  • Massova I, Kotra LP, Fridman R, Mobashery S (1998) Matrix metalloproteinases: Structure evolution and diversification. FASEB J Off Publ Fed Am Soc Exp Biol 12:1075–1095

    CAS  Google Scholar 

  • McKee KK, Harrison D, Capizzi S, Yurchenco PD (2007) Role of laminin terminal globular domains in basement membrane assembly. J Biol Chem 282:21437–21447

    Article  PubMed  CAS  Google Scholar 

  • Menasche P (2007) Skeletal myoblasts as a therapeutic agent. Prog Cardiovasc Dis 50:7–17

    Article  PubMed  Google Scholar 

  • Menasche P (2009) Cell-based therapy for heart disease: a clinically oriented perspective. Mol Ther J Am Soc Gene Ther 17(5):758–766

    Article  CAS  Google Scholar 

  • Mendelson K, Schoen FJ (2006) Heart valve tissue engineering: concepts, approaches, progress, and challenges. Ann Biomed Eng 34:1799–1819

    Article  PubMed  Google Scholar 

  • Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF (2007) Impaired wound healing. Clin Dermatol 25:19–25

    Article  PubMed  Google Scholar 

  • Messaritou G, East L, Roghi C, Isacke CM, Yarwood H (2009) Mebrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. J Cell Sci 122:4042–4048

    Article  PubMed  CAS  Google Scholar 

  • Mias C, Lairez O, Trouche E, Roncalli J, Calise D, Seguelas MH, Ordener C, Piercecchi-Marti MD, Auge N, Salvayre AN, Bourin P, Parini A, Cussac D (2009) Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells 27:2734–2743

    Google Scholar 

  • Mills WR, Mal N, Kiedrowski MJ, Unger R, Forudi F, Popovic ZB, Penn MS, Laurita KR (2007) Stem cell therapy enhances electrical viability in myocardial infarction. J Mol Cell Cardiol 42:314

    Article  CAS  Google Scholar 

  • Mizuno S, Glowacki J (1996) Three-dimensional composite of demineralized bone powder and collagen for in vitro analysis of chondroinduction of human dermal fibroblasts. Exp Cell Res 227:89–97

    Article  PubMed  CAS  Google Scholar 

  • Morais Freitas V, Nogueira da Gama de Souza L, Cyreno Oliveira E, Furuse C, Cavalcanti de Araújo V, Gastaldoni Jaeger R (2007) Malignancy-related 67 kDa laminin receptor in adenoid cystic carcinoma. Effect on migration and beta-catenin expression. Oral Oncol 43:987–998

    Article  PubMed  CAS  Google Scholar 

  • Murphy G, Nagase H (2008) Progress in matrix metalloproteinase research. Mol Asp Med 29:290–308

    Article  CAS  Google Scholar 

  • Myllyharju J, Kivirikko KI (2001) Collagens and collagen-related diseases. Ann Med 33:7–21

    Article  PubMed  CAS  Google Scholar 

  • Naumann A, Dennis JE, Awadallah A, Carrino DA, Mansour JM, Kastenbauer E, Caplan AI (2002) Immunochemical and mechanical characterization of cartilage subtypes in rabbit. J Histochem Cytochem 50:1049–1058

    Article  PubMed  CAS  Google Scholar 

  • Nesselmann C, Ma N, Bieback K, Wagner W, Ho A, Konttinen YT, Zhang H, Hinescu ME, Steinhoff G (2008) Mesenchymal stem cells and cardiac repair. J Cell Mol Med 12:1795–1810

    Article  PubMed  CAS  Google Scholar 

  • Nichols JE, Cortiella J, Lee J, Niles JA, Cuddihy M, Wang S, Bielitzki J, Cantu A, Mlcak R, Valdivia E, Yancy R, McClure ML, Kotov NA (2009) In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry. Biomaterials 30:1071–1079

    Article  PubMed  CAS  Google Scholar 

  • Nie D (2010) Cancer stem cell and niche. Front Biosci 2:184–193

    Article  Google Scholar 

  • Nisato RE, Tille JC, Jonczyk A, Goodman SL, Pepper MS (2003) Alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis 6:105–119

    Article  PubMed  CAS  Google Scholar 

  • Nishioka T, Suzuki M, Onishi K, Takakura N, Inada H, Yoshida T, Hiroe M, Imanaka-Yoshida K (2007) Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation. J Cardiovasc Pharmacol 49:261–268

    Article  PubMed  CAS  Google Scholar 

  • O’Donoghue K, Fisk NM (2004) Fetal stem cells. Best Pract Res Clin Obstet Gynaecol 18:853–875

    Article  PubMed  Google Scholar 

  • Ohga S, Shikata K, Yozai K, Okada S, Ogawa D, Usui H, Wada J, Shikata Y, Makino H (2007) Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. Am J Physiol Ren Physiol 292:F1141–F1150

    Article  CAS  Google Scholar 

  • Park JB, Lakes RS (1992) Biomaterials: an introduction. Plenum, New York

    Book  Google Scholar 

  • Parks WC, Wilson CL, Lopez-Boado YS (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 4:617–629

    Article  PubMed  CAS  Google Scholar 

  • Patarroyo M, Tryggvason K, Virtanen I (2002) Laminins isoforms in tumor invasion, angiogenesis and metastasis. Semin Cancer Biol 12:197–207

    Article  PubMed  CAS  Google Scholar 

  • Paweletz N, Knierim M (1989) Tumor related angiogenesis. Crit Rev Oncol/Hematol 9:197–242

    Article  CAS  Google Scholar 

  • Penn MS, Mangi AA (2008) Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res 102(12):1471–1482

    Article  PubMed  CAS  Google Scholar 

  • Perna AM, Masini E, Nistri S, Bani ST, Bigazzi M, Bani D (2005) Human recombinant relaxin reduces heart injury and improves ventricular performance in a swine model of acute myocardial infarction. Ann N Y Acad Sci 1041:431–433

    Article  PubMed  CAS  Google Scholar 

  • Pommerenke H, Schreiber E, Dürr F, Nebe B, Möller W, Rychly J (1996) Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response. Eur J Cell Biol 70:157–164

    PubMed  CAS  Google Scholar 

  • Poole CA (1992) Chondrons, the chondrocyte and its pericellular microenvironment. In: Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC (eds) Articular cartilage and osteoarthritis. Raven, New York, pp 201–220

    Google Scholar 

  • Rabinovich GA, Rubinstein N, Toscano MA (2002) Role of galectins in inflammatory and immunomodulatory processes. Biochim Biophys Acta 1572:274–284

    Article  PubMed  CAS  Google Scholar 

  • Ramsay AG, Marshall JF, Hart IR (2007) Integrin trafficking and its role in cancer metastasis. Cancer Metastasis Rev 26:567–578

    Article  PubMed  CAS  Google Scholar 

  • Reichenberger E, Baur S, Sukotjo C, Olsen BR, Karimbux NY, Nishimura I (2000) Collagen XII mutation disrupts matrix structure of periodontal ligament and skin. J Dent Res 79:1962–1968

    Article  PubMed  CAS  Google Scholar 

  • Rho JY, Kuhn-Spearing L, Zioupos P (1998) Mechanical properties and the hierarchical structure of bone. Med Eng Phys 20:92–102

    Article  PubMed  CAS  Google Scholar 

  • Ries C, Egea V, Karow M, Kolb H, Jochum M, Neth P (2007) MMP-2, T1-MMP, and TIMP-2 are essential for the invasive capacity of human esenchymal stem cells: Differential regulation by inflammatory cytokines. Blood 109:4055–4063

    Article  PubMed  CAS  Google Scholar 

  • Risteli J, Bachinger HP, Engel J, Furthmayr H, Timpl R (1980) 7-S collagen: characterization of an unusual basement membrane structure. Eur J Biochem 108:239–250

    Article  PubMed  CAS  Google Scholar 

  • Robles DT, Berg D (2007) Abnormal wound healing: keloids. Clin Dermatol 25:26–32

    Article  PubMed  Google Scholar 

  • Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, Doran R, Becher UM, Hwang SM, Bostani T, von Maltzahn J, Hofmann A, Reining S, Eiberger B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel JW, Kotlikoff MI, Fleischmann BK (2007) Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450:819–824

    Article  PubMed  CAS  Google Scholar 

  • Rüster B, Göttig S, Ludwig RJ, Bistrian R, Müller S, Seifried E, Gille J, Henschler R (2006) Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 108:3938–3944

    Article  PubMed  CAS  Google Scholar 

  • Sacks MS, Yoganathan AP (2007) Heart valve function: a biomechanical perspective. Philos Trans R Soc Lond Ser B Biol Sci 362:1369–1391

    Article  Google Scholar 

  • Sasaki K, Takagi M, Konttinen YT, Sasaki A, Tamaki Y, Ogino T, Santavirta S, Salo J (2007) Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. J Biomed Mater Res Part B Appl Biomater 80:491–498

    Article  PubMed  CAS  Google Scholar 

  • Sato A, Aonuma K, Imanaka-Yoshida K, Yoshida T, Isobe M, Kawase D, Kinoshita N, Yazaki Y, Hiroe M (2006) Serum tenascin-C might be a novel predictor of left ventricular remodeling and prognosis after acute myocardial infarction. J Am Coll Cardiol 47:2319–2325

    Article  PubMed  CAS  Google Scholar 

  • Schultz GS, Ladwig G, Wysocki A (2005) Extracellular matrix: review of its roles in acute and chronic wounds. World Wide Wounds. www.worldwidewounds.com/2005/august/Schultz/Extrace-Matric-Acute-Chronic-Wounds.html

  • Sekiya I, Colter DC, Prockop DJ (2001) BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 284:411–418

    Article  PubMed  CAS  Google Scholar 

  • Shanbhag S, Woo Lee J, Kotov N (2005) Diffusion in three-dimensionally ordered scaffolds with inverted colloidal crystal geometry. Biomaterials 26:5581–5585

    Article  PubMed  CAS  Google Scholar 

  • Shimaoka M, Takagi J, Springer TA (2002) Conformational regulation of integrin structure and function. Ann Rev Biophys Biomol Struct 31:485–516

    Article  CAS  Google Scholar 

  • Shimazaki M, Nakamura K, Kii I, Kashima T, Amizuka N, Li M, Saito M, Fukuda K, Nishiyama T, Kitajima S, Saga Y, Fukayama M, Sata M, Kudo A (2008) Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med 205:295–303

    Article  PubMed  CAS  Google Scholar 

  • Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR (2008) Collagen I-mediated upregulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor I. J Cell Biol 180:1277–1289

    Article  PubMed  CAS  Google Scholar 

  • Silva R, D’Amico G, Hodivala-Dilke KM, Reynolds LE (2008) Integrins. The keys to unlocking angiogenesis. Arterioscler Thromb Vasc Biol 28:1703–1713

    Article  PubMed  CAS  Google Scholar 

  • Solchaga LA, Goldberg VM, Caplan AI (2001) Cartilage regeneration using principles of tissue engineering. Clin Orthop Relat Res 391S:S161–S170

    Article  Google Scholar 

  • Steffensen B, Häkkinen L, Larjava H (2001) Proteolytic events of wound-healing – coordinated intractions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules. Crit Rev Oral Biol Med 12:373–398

    Article  PubMed  CAS  Google Scholar 

  • Steingen C, Brenig F, Baumgartner L, Schmidt J, Schmidt A, Bloch W (2008) Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. J Mol Cell Cardiol 44:1072–1084

    Article  PubMed  CAS  Google Scholar 

  • Steinmeyer J, Konttinen YT (2006) Oral treatment options for degenerative joint disease – presence and future. Adv Drug Deliv Rev 58:168–211

    Article  PubMed  CAS  Google Scholar 

  • Sun M, Opavsky A, Stewart DJ, Rabinovtich M, Dawood F, Wen WH, Liu PP (2003) Temporal response and localization of integrins beta-1 and beta-2 in the heart following myocardial infarction: regulation by cytokines. Circulation 107:1046–1052

    Article  PubMed  CAS  Google Scholar 

  • Sund M, Ylönen R, Tuomisto A, Sormunen R, Tahkola J, Kvist AP, Kontusaari S, Autio-Harmainen H, Pihlajaniemi T (2001) Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen. EMBO J 20:5153–5164

    Article  PubMed  CAS  Google Scholar 

  • Sunk IG, Bobacz K, Hofstaetter JG, Amoyo L, Soleiman A, Smolen J, Xu L, Li Y (2007) Increased expression of discoidin domain receptor 2 is linked to the degree of cartilage damage in human knee joints: a potential role in osteoarthritis pathogenesis. Arthritis Rheum 56:3685–3692

    Article  PubMed  CAS  Google Scholar 

  • Takagi M (1996) Neutral proteinases and their inhibitors in the loosening of total hip prosthesis. Acta Orthop Scand 67(Suppl 271):1–29

    Google Scholar 

  • Tamaoki M, Imanaka-Yoshida K, Yokoyama K, Nishioka T, Inada H, Hiroe M, Sakakura T, Yoshida T (2005) Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Am J Pathol 167:71–80

    Article  PubMed  CAS  Google Scholar 

  • Taylor D (2007) Fracture and repair of bone: a multiscale problem. J Mater Sci 42:8911–8918

    Article  CAS  Google Scholar 

  • Tzu J, Marinkovich MP (2008) Bridging structure with function: structural, regulatory, and developmental role of laminins. Int J Biochem Cell Biol 40:199–214

    Article  PubMed  CAS  Google Scholar 

  • Uygun BE, Stojsih SE, Matthew HW (2009) Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells. Tissue Eng Part A 15:3499–3512

    Article  PubMed  CAS  Google Scholar 

  • van der Kraan PM, Buma P, van Kuppevelt T, van den Berg WB (2002) Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering. Osteoarthr Cartil 10:631–637

    Article  PubMed  Google Scholar 

  • van Osch GJ, Brittberg M, Dennis JE, Bastiaansen-Jenniskens YM, Erben RG, Konttinen YT, Luyten FP (2009) Cartilage repair: past and future – lessons for regenerative medicine. J Cell Mol Med 13:792–810

    Article  PubMed  CAS  Google Scholar 

  • Veilleux N, Spector M (2005) Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. Osteoarthr Cartil 13:278–286

    Article  PubMed  CAS  Google Scholar 

  • Veit G, Kobbe B, Keene DR, Paulsson M, Koch M, Wagener R (2006) Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain. J Biol Chem 281:3494–3504

    Article  PubMed  CAS  Google Scholar 

  • Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92:827–839

    Article  PubMed  CAS  Google Scholar 

  • Vuoristo S, Virtanen I, Takkunen M, Palgi J, Kikkawa Y, Rousselle P, Sekiguchi K, Tuuri T, Otonkoski T (2009) Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support. J Cell Mol Med 13:2622–2633

    Article  PubMed  Google Scholar 

  • Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, Goldberg VM (1994) Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Jt Surg Am Vol 76:579–592

    CAS  Google Scholar 

  • Warden S, Zaleske DJ, Glowacki J (2004) Fate of a chimeric joint construct in an ectopic site in SCID mice. Cell Transplant 13:161–168

    PubMed  Google Scholar 

  • Weckroth M, Vaheri A, Lauharanta J, Sorsa T, Konttinen YT (1996) Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers. J Investig Dermatol 106:1119–1124

    Article  PubMed  CAS  Google Scholar 

  • Wienke D, MacFadyen JR, Isacke CM (2003) Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell 14:3592–3604

    Article  PubMed  CAS  Google Scholar 

  • Wu Y, Ip JE, Huang J, Zhang L, Matsushita K, Liew CC, Pratt RE, Dzau VJ (2006) Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circ Res 99:315–322

    Article  PubMed  CAS  Google Scholar 

  • Wu M, Wu ZF, Merajver SD (2007) Rho proteins and cell-matrix interactions in cancer. Cells Tissues Organs 185:100–103

    Article  PubMed  CAS  Google Scholar 

  • Xian X, Gopal S, Couchman JR (2010) Syndecans as receptors and organizers of the extracellular matrix. Cell Tissue Res 339:31–46

    Article  PubMed  CAS  Google Scholar 

  • Xiang G, Schuster MD, Seki T, Kocher AA, Eshghi S, Boyle A, Itescu S (2004) Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors. J Exp Med 200:1657–1666

    Article  PubMed  CAS  Google Scholar 

  • Xiang G, Schuster MD, Seki T, Witkowski P, Eshghi S, Itescu S (2005) Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction. J Am Coll Cardiol 46:536–541

    Article  PubMed  CAS  Google Scholar 

  • Yates KE, Allemann F, Glowacki J (2005) Phenotypic analysis of bovine chondrocytes cultured in 3D collagen sponges: effect of serum substitutes. Cell Tissue Bank 6:45–54

    Article  PubMed  CAS  Google Scholar 

  • Yilmaz M, Christofori G (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 28:15–33

    Article  PubMed  Google Scholar 

  • Yozai K, Shikata K, Sasaki M, Tone A, Ohga S, Usui H, Okada S, Wada J, Nagase R, Ogawa D, Shikata Y, Makino H (2005) Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions. J Am Soc Nephrol 16:3326–3338

    Article  PubMed  CAS  Google Scholar 

  • Zhao S, Wehner R, Bornhäuser M, Wassmuth R, Bachmann M, Schmitz M (2010) Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev 19:607–614

    Google Scholar 

  • Zhou J, Ding M, Zhao Z, Reeders ST (1994) Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. J Biol Chem 269:13193–13199

    PubMed  CAS  Google Scholar 

  • Zimmermann WH, Didié M, Wasmeier GH, Nixdorff U, Hess A, Melnychenko I, Boy O, Neuhuber WL, Weyand M, Eschenhagen T (2002) Cardiac grafting of engineered heart tissue in syngenic rats. Circulation 106(12 Suppl 1):I151–I1157

    PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported EU Matera grant “Bioactive Nanocomposite Constructs for Regeneration of Articular Cartilage”, European Science Foundation “Regenerative Medicine” RNP, Danish Council for Strategic Research, Finska Läkaresällskapet, Orion Foundation and EU COST 533 Biotribology Action.

Author information

Authors and Affiliations

  1. Department of Medicine, Institute of Clinical Medicine, 700, (Haartmaninkatu 8, Biomedicum 1), Helsinki, 00029 HUS, Finland

    Yrjö T. Konttinen M.D., Ph.D., Emilia Kaivosoja M.Sc., Vasily Stegaev M.D. & Jaakko Levón B.Sc.

  2. Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, 76100, Israel

    Hanoch Daniel Wagner Ph.D.

  3. ORTON Orthopaedic Hospital, ORTON Foundation, Tenholantie 10, 00280, Helsinki, Finland

    Veli-Matti Tiainen Ph.D.

  4. Department of Histology and Embryology, Medical University of Bialystok, G. Washington Street 13, 15-269, Bialystok, Poland

    Zygmunt Mackiewicz Ph.D., D.Sc.

Authors
  1. Yrjö T. Konttinen M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emilia Kaivosoja M.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vasily Stegaev M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hanoch Daniel Wagner Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jaakko Levón B.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Veli-Matti Tiainen Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zygmunt Mackiewicz Ph.D., D.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yrjö T. Konttinen M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Konttinen, Y.T. et al. (2013). Extracellular Matrix and Tissue Regeneration. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5690-8_2

Download citation

Publish with us

Policies and ethics

Search

Navigation