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Environmental and Drug Induced Renal Damage; The Way to Protect

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Environmental and Food Safety and Security for South-East Europe and Ukraine

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Abstract

Kidneys are targets of numerous toxicants due to anatomical, physiological and biochemical features of the organs. Factors contributing to the sensitivity of kidneys include large blood flow, presence of a variety of transporters, a lot of functionally necessary metabolizing enzymes, etc. This paper reviews some mechanisms of nephrotoxic action of widely distributed metal compounds and of an anticancer drug cisplatin as a model of drug induced renal damage. Cisplatin is known to induce nephropathy that is restricted primarily to the S3, segment of the proximal tubule, with involvement of S2, and S1 segments at higher doses. This particularity appears to be derived from the distribution of enzymes and transport proteins important for uptake of cisplatin into proximal tubule cells: apical γ-glutamyltranspeptidase and the basolateral organic anion transport system. Regional distributions of transport mechanisms for binding proteins appear to be important in the expression of nephrotoxicity of cisplatin. According to the mechanism of damage the way to protect is proposed with application of antioxidants and mighty antioxidants such as cluster rhenium compounds with organic ligands that contain an unique quadruple bond are demonstrated as nephroprotectors in the model of tumor growth and cisplatin application.

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Authors and Affiliations

  1. Department of Biophysics and Biochemistry, Oles Gonchar Dnipropetrovs’k National University, 72 Gagarin Avenue, 49050, Dnipropetrovs’k, Ukraine

    Svetlana Babiy, Olga Dyomshyna & Natalia I. Shtemenko

  2. Dnipropetrovsk State Medical Academy, Dnipropetrovsk, Ukraine

    Tatiana Loskutova

Authors
  1. Svetlana Babiy
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  2. Olga Dyomshyna
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  3. Tatiana Loskutova
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  4. Natalia I. Shtemenko
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Corresponding author

Correspondence to Svetlana Babiy .

Editor information

Editors and Affiliations

  1. Andrija Stampar School of Public Health, University of Zagreb, Rockefellerova 4, Zagreb, 10000, Croatia

    Ksenija Vitale

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Babiy, S., Dyomshyna, O., Loskutova, T., Shtemenko, N.I. (2012). Environmental and Drug Induced Renal Damage; The Way to Protect. In: Vitale, K. (eds) Environmental and Food Safety and Security for South-East Europe and Ukraine. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2953-7_23

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