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The Role of Multiple Sequence Repeat Motifs in the Assembly of Multi-protein Complexes

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Macromolecular Crystallography

Abstract

Proteins incorporating multiple sequence repeats (for example ARM, HEAT, TPR, LRR and ankyrin) play critical roles in coordinating the assembly of multi-subunit complexes. This lecture will discuss the different types of protein architecture generated by successive copies of each repeat motif type and describe how these structures are suited to the formation of protein-protein interactions, allowing such proteins to function as scaffolding proteins in the assembly of multi-protein complexes.

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Author information

Authors and Affiliations

  1. Division of Structural Biology, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK

    David Barford

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  1. David Barford
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Correspondence to David Barford .

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Editors and Affiliations

  1. , Instit.de Technologia Química e Biológia, Universidade Nova de Lisboa, Rua da Quinta Grande , Apartado 127 6, Oeiras, 2781-901, Portugal

    Maria Armenia Carrondo

  2. Dipto. Scienze Chimiche, Università di Padova, Via F. Marzolo 1, Padova, 35131, Italy

    Paola Spadon

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Barford, D. (2012). The Role of Multiple Sequence Repeat Motifs in the Assembly of Multi-protein Complexes. In: Carrondo, M., Spadon, P. (eds) Macromolecular Crystallography. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2530-0_3

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