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Macromolecular Crystallography

Deciphering the Structure, Function and Dynamics of Biological Molecules

  • Conference proceedings
  • © 2012

Overview

Editors:
  1. Maria Armenia Carrondo

    1. , Instit.de Technologia Química e Biológia, Universidade Nova de Lisboa, Oeiras, Portugal

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  2. Paola Spadon

    1. Dipto. Scienze Chimiche, Università di Padova, Padova, Italy

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (18 papers)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Spatial and Temporal Organisation of Multiprotein Systems of Cell Regulation and Signalling: What Can We Learn from NHEJ System of Double-Strand Break Repair?

    • Qian Wu, Lynn Sibanda, Takashi Ochi, Victor M. Bolanos-Garcia, Tom L. Blundell, Dimitri Y. Chirgadze
    Pages 1-31

  3. Co-translational Protein Processing, Folding, Targeting, and Membrane Insertion of Newly Synthesized Proteins

    • Daniel Boehringer, Nenad Ban
    Pages 33-41

  4. The Role of Multiple Sequence Repeat Motifs in the Assembly of Multi-protein Complexes

    • David Barford
    Pages 43-49

  5. Cryoelectron Tomography or Doing Structural Biology In Situ

    • Wolfgang Baumeister
    Pages 51-54

  6. RuvBL1 and RuvBL2 and Their Complex Proteins Implicated in Many Cellular Pathways

    • Sabine Gorynia, Tiago M. Bandeiras, Pedro M. Matias, Filipa G. Pinho, Colin E. McVey, Peter Donner et al.
    Pages 55-63

  7. The Structural Biology of Muscle: Spatial and Temporal Aspects

    • Kenneth C. Holmes
    Pages 65-78

  8. Molecular Basis of Allosteric Transitions: GroEL

    • Amnon Horovitz
    Pages 79-86

  9. Cell Signalling Through Covalent Modification and Allostery

    • Louise N. Johnson
    Pages 87-92

  10. Combining Cryo-EM and X-ray Crystallography to Study Membrane Protein Structure and Function

    • Werner Kühlbrandt
    Pages 93-101

  11. Molecular Mechanisms of DNA Polymerase Clamp Loaders

    • Brian Kelch, Debora Makino, Kyle Simonetta, Mike O’Donnell, John Kuriyan
    Pages 103-114

  12. Electron Microscopy of Macromolecular Machines

    • Helen R. Saibil
    Pages 115-123

  13. Assembly and Function of the Signal Recognition Particle from Archaea

    • Elisabeth Sauer-Eriksson, Shenghua Huang, Tobias Hainzl
    Pages 125-133

  14. Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target

    • Thomas A. Steitz, Gregor Blaha, C. Axel Innis, Robin Evans Stanley, David Bulkley
    Pages 135-148

  15. Proteopedia: Exciting Advances in the 3D Encyclopedia of Biomolecular Structure

    • Jaime Prilusky, Eran Hodis, Joel L. Sussman
    Pages 149-161

  16. Structure Analysis of Biological Macromolecules by Small-Angle X-ray Scattering

    • Dmitri I. Svergun
    Pages 163-171

  17. Structural Dynamics of the Vault Ribonucleoprotein Particle

    • Arnau Casañas, Jordi Querol, Ignasi Fita, Núria Verdaguer
    Pages 173-182

  18. Structural Dynamics of Picornaviral RdRP Complexes. Implications for the Design of Antivirals

    • Núria Verdaguer, Cristina Ferrer-Orta, Esteban Domingo
    Pages 183-193

  19. Ribosomes: Ribozymes that Survived Evolution Pressures but Is Paralyzed by Tiny Antibiotics

    • Ada Yonath
    Pages 195-208
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Keywords

About this book

This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics.
A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.

Editors and Affiliations

  • , Instit.de Technologia Química e Biológia, Universidade Nova de Lisboa, Oeiras, Portugal

    Maria Armenia Carrondo

  • Dipto. Scienze Chimiche, Università di Padova, Padova, Italy

    Paola Spadon

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