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Human Mesenchymal Stem Cells: Melatonin as a Potential Anti-osteoporosis Drug

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Stem Cells and Cancer Stem Cells,Volume 3

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 3))

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Abstract

Osteoporosis is characterized by low bone mineral density and structural deterioration of bone tissue. It is the most common metabolic bone disorder and affects millions of people in the world, especially prevalence among people over 50 years old. Melatonin, a nuroendocrinal hormone, has been proven to promote bone formation and prevent bone deterioration, although with some controversial results, in osteoblasts, bone cells, and osteoclasts through melatonin receptors-dependent or receptors-independent manner. Recently, researchers found that melatonin can enhance osteogenesis and inhibit adipogenesis in bone marrow-derived mesenchymal stem cells, as a result of that melatonin shift bone marrow precursor cells from an adipocytic line of cell towards osteoblastic differentiation. The objective of this review was to summarize the effect of melatonin on differentiation of bone marrow mesenchymal stem cells.

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Author information

Authors and Affiliations

  1. Department of Orthopedics, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    Dongsheng Huang

  2. Department of Orthopedics, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    Liangming Zhang

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  1. Dongsheng Huang
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  2. Liangming Zhang
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Correspondence to Dongsheng Huang .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Huang, D., Zhang, L. (2012). Human Mesenchymal Stem Cells: Melatonin as a Potential Anti-osteoporosis Drug. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells,Volume 3. Stem Cells and Cancer Stem Cells, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2415-0_20

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