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Stem Cell Distribution and MGMT Expression in Glioblastoma: Role of Intratumoral Hypoxic Gradient

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Stem Cells and Cancer Stem Cells,Volume 3

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 3))

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Abstract

Glioblastoma multiforme (GBM) are highly proliferative tumors currently treated by surgical removal, followed by radiotherapy and chemotherapy, which are counteracted by intra-tumoral hypoxia. Recent findings support novel biological hypotheses that cancer stem cells may contribute to therapy resistance, initiation and maintenance of GBM, which might lead to reconsider the traditional therapeutic approaches. By exploiting image guided surgery it is currently possible to sample multiple intra-tumoral areas, which have been found to be characterized by cellular heterogeneity in correlation to the oxygen tension gradient within the GBM mass. Particularly, the GBM stem cells seem to be mainly localized in the inner core and in the intermediate layer of the tumor mass, and they express high levels of DNA repair protein O6-methylguanine-DNA- methyltransferase (MGMT), known to be involved in chemotherapy resistance. Thus there is a correlation between the intra-tumoral hypoxic gradient, the tumor cell phenotype and the tumor resistance to chemotherapy that has to be taken into account when designing tumor treatment strategies.

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Authors and Affiliations

  1. Hemato-Oncology Laboratory, Department of Paediatrics, University of Padova, Padova, Italy

    Francesca Pistollato & Luca Persano

  2. Department of Neurosurgery, University of Padova, Padova, Italy

    Alessandro Della Puppa

Authors
  1. Francesca Pistollato
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  2. Alessandro Della Puppa
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  3. Luca Persano
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Correspondence to Francesca Pistollato .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Pistollato, F., Della Puppa, A., Persano, L. (2012). Stem Cell Distribution and MGMT Expression in Glioblastoma: Role of Intratumoral Hypoxic Gradient. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells,Volume 3. Stem Cells and Cancer Stem Cells, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2415-0_13

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