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Regioselective Synthesis of Polyfluorinated Pyrazoles and Evaluation of Antimicrobial Activity

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Chemistry for Sustainable Development

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Abstract

A series of 1,3,5-trisubstituted pyrazole derivatives were prepared from one asymmetrical polyfluorinated 1,3-diketone. The reactivity of substituted hydrazines towards the diketone compound is studied leading to the formation of regioisomers. The polyfluorinated pyrazoles were utilized for the alkylation with N-aryl acetamides to yield N-alkyl products. Then they were hooked with amino acid esters such as L-phenylalanine, L-proline, L-tyrosine, and L-norvaline by multistep process. The antimicrobial activities of the synthesized pyrazoles were evaluated. All synthesized compounds were characterized by spectroscopic and analytical methods.

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Acknowledgements

The authors gratefully acknowledge financial support of this project by UGC, New Delhi, BCUD, University of Pune, India and Principal, K. T. H. M. College, Nashik – 422 002 for facilities.

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Authors and Affiliations

  1. Organic Chemistry Research Centre, Department of Chemistry, K. T. H. M. College, Gangapur Road, Nashik, 422 002, Maharashtra, India

    Madhukar N. Jachak, Dilip R. Birari, Deepak P. Shelar, Sandeep R. Patil, Ramhari V. Rote, Santosh S. Shinde & Sandip M. Bagul

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  1. Madhukar N. Jachak
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  2. Dilip R. Birari
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Correspondence to Madhukar N. Jachak .

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Editors and Affiliations

  1. Faculty of Science, Dept. Chemistry, University of Mauritius, Reduit, Mauritius

    Minu Gupta Bhowon

  2. Faculty of Science, Dept. Chemistry, University of Mauritius, Reduit, Mauritius

    Sabina Jhaumeer-Laulloo

  3. Faculty of Science, Dept. Chemistry, University of Mauritius, Reduit, Mauritius

    Henri Li Kam Wah

  4. Faculty of Science, Dept. Chemistry, University of Mauritius, Reduit, Mauritius

    Ponnadurai Ramasami

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Jachak, M.N. et al. (2012). Regioselective Synthesis of Polyfluorinated Pyrazoles and Evaluation of Antimicrobial Activity. In: Gupta Bhowon, M., Jhaumeer-Laulloo, S., Li Kam Wah, H., Ramasami, P. (eds) Chemistry for Sustainable Development. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8650-1_8

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