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General Aspects of Organocatalytic Cyclizations

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Enantioselective Organocatalyzed Reactions II

Abstract

Ring-forming reactions are an essential part of synthetic chemistry and allow access to a range of useful natural products and biologically important molecules. The applications of organocatalysis to the synthesis of functionalised, enantiopure structures really begins where organocatalysis itself begins; with the Hajos-Parrish reaction in the 1970s for the synthesis of steroids using proline. This chapter then will review the uses of organocatalysts in cyclization methodology – from the initial Hajos-Parrish discovery to current advances in the field.

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Authors and Affiliations

  1. University of Reading, Whiteknights, Reading, RG6 6AD, Berkshire, UK

    Alexander J. André Cobb

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  1. Alexander J. André Cobb
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Correspondence to Alexander J. André Cobb .

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Editors and Affiliations

  1. Department of Chemistry, Humboldt University Berlin, Brook-Taylor-Str. 2, Berlin, 12489, Berlin, Germany

    Rainer Mahrwald

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Cobb, A.J.A. (2011). General Aspects of Organocatalytic Cyclizations. In: Mahrwald, R. (eds) Enantioselective Organocatalyzed Reactions II. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3867-8_1

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