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What does Evolution Teach us about Nuclear Receptors?

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Nuclear Receptors

Part of the book series: Proteins and Cell Regulation ((PROR,volume 8))

Abstract

In this chapter we first summarise the current knowledge about the phylogenetic spectrum of nuclear receptors (NRs). Then, we discuss how studying their diversity can be helpful to make insights about their evolution. Significant attention is paid to the evolution of ligand-binding ability. Recent evolutionary and functional data have challenged the traditional concept of ligand, providing a more complex view of the mechanisms by which the transcriptional activity of NRs can be modulated. Finally, we argue that the evolutionary analysis of NRs has contributed to a conceptual shift of our understanding of nuclear receptors, from highly specific endocrine regulators to a promiscuous metabolic rheostat.

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REFERENCES

  1. Laudet, V., Hänni, C., Coll, J., Catzeflis, F., and Stéhelin, D. (1992). Evolution of the nuclear receptor gene superfamily. EMBO J 11(3), 1003–1013.

    CAS  PubMed  Google Scholar 

  2. Amero, S. A., Kretsinger, R. H., Moncrief, N. D., Yamamoto, K. R., and Pearson, W. R. (1992). The origin of nuclear receptor proteins: A single precursor distinct from other transcription factors. Mol Endocrinol 6(1), 3–7.

    Article  CAS  PubMed  Google Scholar 

  3. Laudet, V. (1997). Evolution of the nuclear receptor superfamily: Early diversification from an ancestral orphan receptor. J Mol Endocrinol 19(3), 207–226.

    Article  CAS  PubMed  Google Scholar 

  4. Nuclear Receptors Nomenclature Committee (1999). A unified nomenclature system for the nuclear receptor superfamily. Cell 97(2), 161–163.

    Article  Google Scholar 

  5. Brelivet, Y., Kammerer, S., Rochel, N., Poch, O., and Moras, D. (2004). Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level. EMBO Rep 5(4), 423–429, DOI10.1038/sj.embor.7400119.

    Article  CAS  PubMed  Google Scholar 

  6. Arnosti, D. N., Gray, S., Barolo, S., Zhou, J., and Levine, M. (1996). The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo. EMBO J 15(14), 3659–3666.

    CAS  PubMed  Google Scholar 

  7. Båvner, A., Sanyal, S., Gustafsson, J. A., and Treuter, E. (2005). Transcriptional corepression by SHP: Molecular mechanisms and physiological consequences. Trends Endocrinol Metab 16(10), 478–488, DOI10.1016/j.tem.2005.10.005.

    Article  PubMed  Google Scholar 

  8. Miyata, T. and Suga, H. (2001). Divergence pattern of animal gene families and relationship with the cambrian explosion. Bioessays 23(11), 1018–1027, DOI10.1002/bies.1147.

    Article  CAS  PubMed  Google Scholar 

  9. Escriva, H., Safi, R., Hänni, C., Langlois, M. C., Saumitou-Laprade, P., Stehelin, D., Capron, A., Pierce, R., and Laudet, V. (1997). Ligand binding was acquired during evolution of nuclear receptors. Proc Natl Acad Sci U S A 94(13), 6803–6808.

    Article  CAS  PubMed  Google Scholar 

  10. Bertrand, S., Brunet, F. G., Escriva, H., Parmentier, G., Laudet, V., and Robinson-Rechavi, M. (2004). Evolutionary genomics of nuclear receptors: From twenty-five ancestral genes to derived endocrine systems. Mol Biol Evol 21(10), 1923–1937, DOI10.1093/molbev/msh200.

    Article  CAS  PubMed  Google Scholar 

  11. Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P. L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007). Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. PLoS Genet 3(11), e188, DOI10.1371/journal.pgen.0030188.

    Article  PubMed  Google Scholar 

  12. Schubert, M., Brunet, F., Paris, M., Bertrand, S., Benoit, G., and Laudet, V. (2008). Nuclear hormone receptor signaling in amphioxus. Dev Genes Evol, DOI10.1007/s00427-008-0251-y.

    Google Scholar 

  13. Sluder, A. E. and Maina, C. V. (2001). Nuclear receptors in nematodes: Themes and variations. Trends Genet 17(4), 206–213.

    Article  CAS  PubMed  Google Scholar 

  14. Robinson-Rechavi, M., Maina, C. V., Gissendanner, C. R., Laudet, V., and Sluder, A. (2005). Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. J Mol Evol 60(5), 577–586, DOI10.1007/s00239-004-0175-8.

    Article  CAS  PubMed  Google Scholar 

  15. Yates, R. A., Tuan, R. S., Shepley, K. J., and Unnasch, T. R. (1995). Characterization of genes encoding members of the nuclear hormone receptor superfamily from Onchocerca volvulus. Mol Biochem Parasitol 70(1–2), 19–31.

    Article  CAS  PubMed  Google Scholar 

  16. Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M., Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B. W., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrín-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L., and Scott, A. L. (2007). Draft genome of the filarial nematode parasite Brugia malayi. Science 317(5845), 1756–1760, DOI10.1126/science.1145406.

    Article  CAS  PubMed  Google Scholar 

  17. Abad, P., Gouzy, J., Aury, J. M., Castagnone-Sereno, P., Danchin, E. G. J., Deleury, E., Perfus-Barbeoch, L., Anthouard, V., Artiguenave, F., Blok, V. C., Caillaud, M. C., Coutinho, P. M., Dasilva, C., Luca, F. D., Deau, F., Esquibet, M., Flutre, T., Goldstone, J. V., Hamamouch, N., Hewezi, T., Jaillon, O., Jubin, C., Leonetti, P., Magliano, M., Maier, T. R., Markov, G. V., McVeigh, P., Pesole, G., Poulain, J., Robinson-Rechavi, M., Sallet, E., Ségurens, B., Steinbach, D., Tytgat, T., Ugarte, E., van Ghelder, C., Veronico, P., Baum, T. J., Blaxter, M., Bleve-Zacheo, T., Davis, E. L., Ewbank, J. J., Favery, B., Grenier, E., Henrissat, B., Jones, J. T., Laudet, V., Maule, A. G., Quesneville, H., Rosso, M. N., Schiex, T., Smant, G., Weissenbach, J., and Wincker, P. (2008). Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nat Biotechnol 26(8), 909–915, DOI10.1038/nbt.1482.

    Article  CAS  PubMed  Google Scholar 

  18. Dieterich, C., Clifton, S. W., Schuster, L. N., Chinwalla, A., Delehaunty, K., Dinkelacker, I., Fulton, L., Fulton, R., Godfrey, J., Minx, P., Mitreva, M., Roeseler, W., Tian, H., Witte, H., Yang, S. P., Wilson, R. K., and Sommer, R. J. (2008). The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism. Nat Genet 40(10), 1193–1198, DOI10.1038/ng.227.

    Article  CAS  PubMed  Google Scholar 

  19. Wu, W., Niles, E. G., Hirai, H., and LoVerde, P. T. (2007). Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains. BMC Evol Biol 7, 27, DOI10.1186/1471-2148-7-27.

    Article  PubMed  Google Scholar 

  20. King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., Marr, M., Pincus, D., Putnam, N., Rokas, A., Wright, K. J., Zuzow, R., Dirks, W., Good, M., Goodstein, D., Lemons, D., Li, W., Lyons, J. B., Morris, A., Nichols, S., Richter, D. J., Salamov, A., Sequencing, J. G. I., Bork, P., Lim, W. A., Manning, G., Miller, W. T., McGinnis, W., Shapiro, H., Tjian, R., Grigoriev, I. V., and Rokhsar, D. (2008). The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature 451(7180), 783–788, DOI10.1038/nature06617.

    Article  CAS  PubMed  Google Scholar 

  21. Phelps, C., Gburcik, V., Suslova, E., Dudek, P., Forafonov, F., Bot, N., MacLean, M., Fagan, R. J., and Picard, D. (2006). Fungi and animals may share a common ancestor to nuclear receptors. Proc Natl Acad Sci U S A 103(18), 7077–7081, DOI10.1073/pnas.0510080103.

    Article  CAS  PubMed  Google Scholar 

  22. Thakur, J. K., Arthanari, H., Yang, F., Pan, S. J., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D. K., Mylonakis, E., Struhl, K., Moye-Rowley, W. S., Cormack, B. P., Wagner, G., and Näär, A. M. (2008). A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452(7187), 604–609, DOI10.1038/nature06836.

    Article  CAS  PubMed  Google Scholar 

  23. Furness, S. G. B., Lees, M. J., and Whitelaw, M. L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Lett 581(19):3616–3625, DOI10.1016/j. febslet. 200704.011.

    Article  CAS  PubMed  Google Scholar 

  24. Murphy, K. A., Quadro, L., and White, L. A. (2007). The intersection between the aryl hydrocarbon receptor (AHR)- and retinoic acid-signaling pathways. Vitam Horm 75, 33–67, DOI10.1016/S0083-6729(06)75002-6.

    Article  CAS  PubMed  Google Scholar 

  25. Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., and Kato, S. (2007). Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446(7135), 562–566, DOI10.1038/nature05683.

    Article  CAS  PubMed  Google Scholar 

  26. Konopova, B. and Jindra, M. (2007). Juvenile hormone resistance gene methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum. Proc Natl Acad Sci U S A 104(25), 10,488–10,493, DOI10.1073/pnas.0703719104.

    Article  Google Scholar 

  27. Soccio, R. E. and Breslow, J. L. (2003). Star-related lipid transfer (start) proteins: Mediators of intracellular lipid metabolism. J Biol Chem 278(25), 22,183–22,186, DOI10.1074/jbc.R300003200.

    Article  Google Scholar 

  28. Tsujishita, Y. and Hurley, J. H. (2000). Structure and lipid transport mechanism of a star-related domain. Nat Struct Biol 7(5), 408–414, DOI10.1038/75192.

    Article  CAS  PubMed  Google Scholar 

  29. Schrick, K., Nguyen, D., Karlowski, W. M., and Mayer, K. F. X. (2004). Start lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors. Genome Biol 5(6), R41, DOI10.1186/gb-2004-5-6-r41.

    Article  PubMed  Google Scholar 

  30. Kushiro, T., Nambara, E., and McCourt, P. (2003). Hormone evolution: The key to signalling. Nature 422(6928), 122, DOI10.1038/422122a.

    Article  CAS  PubMed  Google Scholar 

  31. Beckett, D. (2001). Regulated assembly of transcription factors and control of transcription initiation. J Mol Biol 314(3), 335–352, DOI10.1006/jmbi.2001.5134.

    Article  CAS  PubMed  Google Scholar 

  32. Jacob, F. and Monod, J. (1961). Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol 3, 318–356.

    Article  CAS  PubMed  Google Scholar 

  33. Lewis, M. (2005). The lac repressor. C R Biol 328(6), 521–548, DOI10.1016/j.crvi.2005.04.004.

    Google Scholar 

  34. Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P., and Hogness, D. S. (1991). The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67(1), 59–77.

    Article  CAS  PubMed  Google Scholar 

  35. Calléja, C., Messaddeq, N., Chapellier, B., Yang, H., Krezel, W., Li, M., Metzger, D., Mascrez, B., Ohta, K., Kagechika, H., Endo, Y., Mark, M., Ghyselinck, N. B., and Chambon, P. (2006). Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes Dev 20(11), 1525–1538, DOI10.1101/gad.368706.

    Article  PubMed  Google Scholar 

  36. Rocchi, S., Picard, F., Vamecq, J., Gelman, L., Potier, N., Zeyer, D., Dubuquoy, L., Bac, P., Champy, M. F., Plunket, K. D., Leesnitzer, L. M., Blanchard, S. G., Desreumaux, P., Moras, D., Renaud, J. P., and Auwerx, J. (2001). A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 8(4), 737–747.

    Article  CAS  PubMed  Google Scholar 

  37. Wang, Y., Chirgadze, N. Y., Briggs, S. L., Khan, S., Jensen, E. V., and Burris, T. P. (2006). A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta. Proc Natl Acad Sci U S A 103(26), 9908–9911.

    Article  CAS  PubMed  Google Scholar 

  38. Thummel, C. S. (2005). Powered by gas–a ligand for a fruit fly nuclear receptor. Cell 122(2): 151–153, DOI10.1016/j.cell.2005.07.007.

    Article  CAS  PubMed  Google Scholar 

  39. Clayton, G. M., Peak-Chew, S. Y., Evans, R. M., and Schwabe, J. W. (2001). The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. Proc Natl Acad Sci U S A 98(4), 1549–1554, DOI10.1073/pnas.041611298.

    Article  CAS  PubMed  Google Scholar 

  40. Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y. I., and Shoelson, S. E. (2002). Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J Biol Chem 277(41), 37,973–37,976, DOI10.1074/jbc.C200420200.

    Article  Google Scholar 

  41. Weihua, Z., Lathe, R., Warner, M., and Gustafsson, J. A. (2002). An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A 99(21), 13,589–13,594, DOI10.1073/pnas.162477299.

    Article  Google Scholar 

  42. Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I. S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W., and Mangelsdorf, D. J. (2007). 27-hydroxycholesterol is an endogenous serm that inhibits the cardiovascular effects of estrogen. Nat Med 13(10), 1185–1192, DOI10.1038/nm1641.

    Article  CAS  PubMed  Google Scholar 

  43. Escriva, H., Bertrand, S., Germain, P., Robinson-Rechavi, M., Umbhauer, M., Cartry, J., Duffraisse, M., Holland, L., Gronemeyer, H., and Laudet, V. (2006). Neofunctionalization in vertebrates: The example of retinoic acid receptors. PLoS Genet 2(7), e102, DOI10.1371/journal.pgen.0020102.

    Article  PubMed  Google Scholar 

  44. Iwema, T., Billas, I. M. L., Beck, Y., Bonneton, F., Nierengarten, H., Chaumot, A., Richards, G., Laudet, V., and Moras, D. (2007). Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor. EMBO J 26(16), 3770–3782, DOI10.1038/sj.emboj.7601810.

    Article  CAS  PubMed  Google Scholar 

  45. Krasowski, M. D., Yasuda, K., Hagey, L. R., and Schuetz, E. G. (2005). Evolution of the pregnane X receptor: Adaptation to cross-species differences in biliary bile salts. Mol Endocrinol 19(7), 1720–1739, DOI10.1210/me.2004-0427.

    Article  CAS  PubMed  Google Scholar 

  46. Reschly, E. J., Bainy, A. C. D., Mattos, J. J., Hagey, L. R., Bahary, N., Mada, S. R., Ou, J., Venkataramanan, R., and Krasowski, M. D. (2007). Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol 7, 222, DOI10.1186/1471-2148-7-222.

    Article  PubMed  Google Scholar 

  47. Escriva, H., Delaunay, F., and Laudet, V. (2000). Ligand binding and nuclear receptor evolution. Bioessays 22(8), 717–727, DOI3.0.CO;2-I.

    Article  CAS  PubMed  Google Scholar 

  48. Baker, M. E. (2003). Evolution of adrenal and sex steroid action in vertebrates: A ligand-based mechanism for complexity. Bioessays 25(4), 396–400, DOI10.1002/bies.10252.

    Article  CAS  PubMed  Google Scholar 

  49. Popov, V. M., Wang, C., Shirley, L. A., Rosenberg, A., Li, S., Nevalainen, M., Fu, M., and Pestell, R. G. (2007). The functional significance of nuclear receptor acetylation. Steroids 72(2):221–230, DOI10.1016/j.steroids.2006.12.001.

    Article  CAS  PubMed  Google Scholar 

  50. Thornton, J. W. (2001). Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. Proc Natl Acad Sci U S A 98(10), 5671–5676, DOI10.1073/pnas.091553298.

    Article  CAS  PubMed  Google Scholar 

  51. Thornton, J. W., Need, E., and Crews, D. (2003). Resurrecting the ancestral steroid receptor: Ancient origin of estrogen signaling. Science 301(5640), 1714–1717, DOI10.1126/science.1086185.

    Article  CAS  PubMed  Google Scholar 

  52. Bridgham, J. T., Carroll, S. M., and Thornton, J. W. (2006). Evolution of hormone-receptor complexity by molecular exploitation. Science 312(5770), 97–101, DOI10.1126/science.1123348.

    Article  CAS  PubMed  Google Scholar 

  53. Lafont, R. and Mathieu, M. (2007). Steroids in aquatic invertebrates. Ecotoxicology 16(1), 109–130, DOI10.1007/s10646-006-0113-1.

    Article  CAS  PubMed  Google Scholar 

  54. Markov, G. V., Paris, M., Bertrand, S., and Laudet, V. (2008). The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics. Mol Cell Endocrinol 293(1–2), 5–16, DOI10.1016/j.mce.2008.06.011.

    Article  CAS  PubMed  Google Scholar 

  55. Rottiers, V., Motola, D. L., Gerisch, B., Cummins, C. L., Nishiwaki, K., Mangelsdorf, D. J., and Antebi, A. (2006). Hormonal control of C. elegans dauer formation and life span by a rieske-like oxygenase. Dev Cell 10(4):473–482, DOI10.1016/j.devcel.2006.02.008.

    Article  CAS  PubMed  Google Scholar 

  56. Rewitz, K. F., Rybczynski, R., Warren, J. T., and Gilbert, L. I. (2006). The halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormone. Biochem Soc Trans 34(Pt 6), 1256–1260, DOI10.1042/BST0341256.

    CAS  PubMed  Google Scholar 

  57. Lokman, P. M., Harris, B., Kusakabe, M., Kime, D. E., Schulz, R. W., Adachi, S., and Young, G. (2002). 11-oxygenated androgens in female teleosts: Prevalence, abundance, and life history implications. Gen Comp Endocrinol 129(1), 1–12.

    Article  PubMed  Google Scholar 

  58. Bury, N. R., Sturm, A., Rouzic, P. L., Lethimonier, C., Ducouret, B., Guiguen, Y., Robinson-Rechavi, M., Laudet, V., Rafestin-Oblin, M. E., and Prunet, P. (2003). Evidence for two distinct functional glucocorticoid receptors in teleost fish. J Mol Endocrinol 31(1), 141–156.

    Article  CAS  PubMed  Google Scholar 

  59. Paris, M., Escriva, H., Schubert, M., Brunet, F., Brtko, J., Ciesielski, F., Roecklin, D., Vivat-Hannah, V., Jamin, E. L., Cravedi, J. P., Scanlan, T. S., Renaud, J. P., Holland, N. D., and Laudet, V. (2008). Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol 18(11), 825–830, DOI10.1016/j.cub.2008.04.078.

    Article  CAS  PubMed  Google Scholar 

  60. Paris, M. and Laudet, V. (2008). The history of a developmental stage: Metamorphosis in chordates. Genesis 46(11), 657-672, DOI10.1002/dvg.20443.

    Article  CAS  PubMed  Google Scholar 

  61. Ben-Shlomo, I. and Hsueh, A. J. W. (2005). Three’s company: Two or more unrelated receptors pair with the same ligand. Mol Endocrinol 19(5), 1097–1109, DOI10.1210/me.2004-0451.

    Article  CAS  PubMed  Google Scholar 

  62. Wisely, G. B., Miller, A. B., Davis, R. G., Thornquest, A. D., Johnson, R., Spitzer, T., Sefler, A., Shearer, B., Moore, J. T., Miller, A. B., Willson, T. M., and Williams, S. P. (2002). Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10(9), 1225–1234.

    Article  CAS  PubMed  Google Scholar 

  63. Reschly, E. J. and Krasowski, M. D. (2006). Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Curr Drug Metab 7(4), 349–365.

    Article  CAS  PubMed  Google Scholar 

  64. Bonneton, F., Brunet, F. G., Kathirithamby, J., and Laudet, V. (2006). The rapid divergence of the ecdysone receptor is a synapomorphy for mecopterida that clarifies the strepsiptera problem. Insect Mol Biol 15(3), 351–362, DOI 10.1111/j.1365-2583.2006.00654.x.

    Article  CAS  PubMed  Google Scholar 

  65. Wu, W., Niles, E. G., El-Sayed, N., Berriman, M., and LoVerde, P. T. (2006). Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: Sixteen new members and a novel subfamily. Gene 366, 303–315.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut de Génomique Fonctionnelle de Lyon; Université de Lyon; Université Lyon 1; CNRS; INRA; Ecole Normale Supérieure de Lyon, Lyon cedex, France

    Gabriel Markov, FranÇois Bonneton & Vincent Laudet

  2. USM 501 – Evolution des Régulations Endocriniennes. Muséum National d’Histoire Naturelle, Paris, France

    Gabriel Markov

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  1. Gabriel Markov
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  1. School of Biosciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom

    Chris M. Bunce

  2. Dept. Pharmacology & Therapeutics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, 14263, U.S.A.

    Moray J. Campbell

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Markov, G., Bonneton, F., Laudet, V. (2010). What does Evolution Teach us about Nuclear Receptors?. In: Bunce, C., Campbell, M. (eds) Nuclear Receptors. Proteins and Cell Regulation, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3303-1_2

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