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Thyroid Cancer: Identification of Gene Expression Markers for Diagnosis

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Methods of Cancer Diagnosis, Therapy, and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 7))

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Abstract

The human genome contains tens of thousands of gene loci which code for an even greater number of different protein and RNA products. The highly complex temporal and spatial expression of these genes makes possible all the biological processes of life from development and differentiation to homeostasis, aging, and programmed cell death. Therefore, it is not surprising that altered gene expression by mutation or deregulation is fundamental for the development of many human diseases including cancer. In some cases, cancers can be linked to large changes such as deletions or duplications of entire gene(s). In other cases, more subtle changes in expression levels of larger numbers of genes are involved. Until recently, cancer diagnosis was dependent on pathological methods and imaging studies that often require a tumor of significant size and suffer from poor sensitivity (Ahmed 2002). The recent development of gene expression profiling tools, promises to identify new and improved diagnostic tools at the molecular level.

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Authors and Affiliations

  1. Michael Smith Genome Sciences Center, British Columbia Cancer Agency, Vancouver, V5Z 1L3, Canada

    Obi L. Griffith & Steven J. M. Jones

  2. Department of Surgery, University of British Columbia, 910 West 10th Avenue, Vancouver, B.C., Canada, V5Z 4E3

    Adrienne Melck

  3. Department of Surgery, Saint Paul’s Hospital, Room C303, Burrard Bldg, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada

    Sam M. Wiseman

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  1. Obi L. Griffith
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  1. Dept. Biological Sciences, Kean University, Union, 07083, USA

    M. A. Hayat

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Griffith, O.L., Melck, A., Jones, S.J.M., Wiseman, S.M. (2010). Thyroid Cancer: Identification of Gene Expression Markers for Diagnosis. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3186-0_24

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  • DOI: https://doi.org/10.1007/978-90-481-3186-0_24

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-3185-3

  • Online ISBN: 978-90-481-3186-0

  • eBook Packages: MedicineMedicine (R0)

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