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Antimicrobiële peptiden in speeksel

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Speeksel en speekselklieren

Samenvatting

Antimicrobiële peptiden (AMP’s) spelen een belangrijke rol in de verdediging van orale weefsels. AMP’s bezitten een netto positieve lading en hebben amfipathische eigenschappen. Ze binden aan membranen van micro-organismen, waardoor deze lek raken en de bacterie of schimmel sterft. Speeksel bevat drie groepen AMP’s: histatinen, defensinen en het cathelicidine peptide LL-37. Alle drie doden ze een breed scala aan micro-organismen en schimmels. Verder hebben ze epitheelcel-stimulerende eigenschappen en versnellen ze wondgenezing. Daarnaast bezitten LL-37 en defensinen ook immuunmodulerende eigenschappen. Vanwege hun simpele structuur zijn AMP’s relatief gemakkelijk op grote schaal te maken. Hierdoor zijn ze potentieel toepasbaar als breedwerkende antimicrobiële agentia.

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Authors and Affiliations

  1. Sectie Orale Biochemie, Academisch Centrum Tandheelkunde Amsterdam, Amsterdam, The Netherlands

    W. van ’t Hof & E.C.I. Veerman

Authors
  1. W. van ’t Hof
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  2. E.C.I. Veerman
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Editor information

Editors and Affiliations

  1. Amsterdam, Noord-Holland, The Netherlands

    E.C.I. Veerman

  2. Groningen, The Netherlands

    A. Vissink

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© 2014 Bohn Stafleu van Loghum

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van ’t Hof, W., Veerman, E. (2014). Antimicrobiële peptiden in speeksel. In: Veerman, E., Vissink, A. (eds) Speeksel en speekselklieren. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0387-8_6

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  • DOI: https://doi.org/10.1007/978-90-368-0387-8_6

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0386-1

  • Online ISBN: 978-90-368-0387-8

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