Skip to main content

The History: From Ivar Sandström to the Sequence of Parathyroid Hormone

  • Chapter
  • First Online:
Hypoparathyroidism

Abstract

The history of the discovery of the parathyroid glands and the evolution of knowledge about parathyroid hormone (PTH) are rewarding for the insights it provides into the basic physiology and pathophysiology of bone and mineral metabolism and the diseases hypoparathyroidism and hyperparathyroidism. The early history illustrates the surprising contradictions and confusion that can occur in scientific investigations along the pathway to a clearer understanding of biology and disease. This chapter will focus on hypoparathyroidism consistent with the theme of this volume.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sandström I (1880) Om en ny körtel hos menniskan och åtskilliga däggdjur. Upsala Lakareforen Forh 15:441–471

    Google Scholar 

  2. Seipel CM (1938) An english translation of Sandström’s Glandulae Parathyreoideae. Bull Inst Hist Med 6:179–222

    Google Scholar 

  3. Owen R (1862) On the anatomy of the Indian rhinoceros. Trans Zool Soc Lond 4:31–58

    Google Scholar 

  4. Nordenström J (2013) The hunt for the parathyroids. Karolinska Institute University Press, Stockholm

    Google Scholar 

  5. Boothby WM (1921) The parathyroid glands: a review of the literature. Endocrinology 5:403–440

    Article  Google Scholar 

  6. Baber EC (1881) Researches on the minute structure of the thyroid gland. Philos Trans 172:577–608

    Article  Google Scholar 

  7. Horsley V (1892) Remarks on the function of the thyroid gland: a critical historical review. Br Med J 1(215–219):265–268

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Gley E (1891) Sur les fonctions du corps thyroide. Comptes Rendus Soc Biol Paris 43:841–842

    Google Scholar 

  9. Gley E (1891) Sur la toxicité des urine des chiens thyroîdectomisés. Contribution a l’étude des fonctions du corps thyroïde. Comptes Rendus Soc Biol Paris 3:366–368

    Google Scholar 

  10. Vassale G, Generali F (1896) Sur les effets de l’extirpation des glandes parathyréoïdes. Arch Ital Biol 25:459–464

    Google Scholar 

  11. Vassale G, Generali F (1896) Fonction parathyroidienne et fonction thyroidienne. Arch Ital Biol 33:154–155

    Google Scholar 

  12. Erdheim J (1911) Über die Dentinverkalkung im Nagezahn bei der Epithelkörperchentransplantation. Frankfurt Z Pathol 7:295–347

    CAS  Google Scholar 

  13. MacCallum WG, Voegtlin C (1909) On the relation of tetany to the parathyroid glands and to calcium metabolism. J Exp Med 11:118–161

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Parhon C, Urechie CS (1907) Untersuchungen über den Einfluss den die Calcium and Sodiumsalze auf den Verlauf der experimentellen Tetanie ausüben. Neurol Centralbl 26:1099

    Google Scholar 

  15. Koch WF (1913) Toxic bases in the urine of parathyroidectomized dogs. J Biol Chem 15:43–63

    CAS  Google Scholar 

  16. Koch WF (1915) The physiology of the parathyroid glands. J Labor Clin Med 1:299–315

    Google Scholar 

  17. Paton DN, Findlay L, Burns D (1914–1915) On guanidine or methylguanidine as a toxic agent in the tetany following parathyroidectomy. J Physiol 49:17–18

    Google Scholar 

  18. Collip JB (1925) The extraction of a parathyroid hormone which will prevent or control parathyroid tetany and which regulates the level of blood calcium. J Biol Chem 63:395–438

    CAS  Google Scholar 

  19. Collip JB, Leitch DB (1925) A case of tetany treated with parathyrin. Can Med Assoc J 15:59–60

    PubMed Central  CAS  PubMed  Google Scholar 

  20. Hanson AM (1923) An elementary chemical study of the parathyroid glands of cattle. Mil Surg 53:280–284

    Google Scholar 

  21. Hanson AM (1924) Experiments with active preparations of parathyroid other than that of desiccated gland. Mil Surg 53:701–718

    Google Scholar 

  22. Albright F, Ellsworth R (1929) Studies on the physiology of the parathyroid glands: I. Calcium and phosphorus studies on a case of idiopathic hypoparathyroidism. J Clin Invest 7:183–201

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Albright F, Burnett CH, Smith PH (1942) Pseudo-hypoparathyroidism – an example of ‘Seabright-Bantam syndrome’: report of three cases. Endocrinology 30:922–932

    CAS  Google Scholar 

  24. Albright F, Forbes AP, Henneman PH (1952) Pseudo-pseudohypoparathyroidism. Trans Assoc Am Phys 65:337–350

    CAS  PubMed  Google Scholar 

  25. Sanger F (1949) The terminal peptides of insulin. Biochem J 45:563–574

    PubMed Central  CAS  PubMed  Google Scholar 

  26. Handler P, Cohn DU, Dratz AF (1954) Metabolic interrelations with special reference to calcium. In: 5th Josiah Macy conference. Progress Associated, Inc, New York

    Google Scholar 

  27. Aurbach GD (1959) Isolation of parathyroid hormone after extraction with phenol. J Biol Chem 234:3179–3181

    CAS  PubMed  Google Scholar 

  28. Rasmussen H, Craig L (1959) Purification of parathyroid hormone by use of countercurrent distribution. J Am Chem Soc 81:5003

    Article  CAS  Google Scholar 

  29. Niall HD, Keutmann H, Sauer R, Hogan M, Dawson B, Aurbach G, Potts J Jr (1970) The amino acid sequence of bovine parathyroid hormone I. Hoppe Seylers Z Physiol Chem 351:1586–1588

    CAS  PubMed  Google Scholar 

  30. Brewer HB Jr, Ronan R (1970) Bovine parathyroid hormone: amino acid sequence. Proc Natl Acad Sci U S A 67:1862–1869

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. Keutmann HT, Sauer MM, Hendy GN, O’Riordan LH, Potts JT Jr (1978) Complete amino acid sequence of human parathyroid hormone. Biochemistry 17:5723–5729

    Article  CAS  PubMed  Google Scholar 

  32. Potts JT Jr, Tregear GW, Keutmann HT, Niall HD, Sauer R, Deftos LJ, Dawson BF, Hogan ML, Aurbach GD (1971) Synthesis of a biologically active N-terminal tetratriacontapeptide of parathyroid hormone. Proc Natl Acad Sci U S A 68:63–67

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  33. Tregear GW, van Rietschoten J, Greene E, Niall HD, Keutmann HT, Parsons JA, O’Riordan JL, Potts JT Jr (1974) Solid-phase synthesis of the biologically active N-terminal 1–34 peptide of human parathyroid hormone. Hoppe Seylers Z Physiol Chem 355:415–421

    Article  CAS  PubMed  Google Scholar 

  34. Ekins R (1980) More sensitive immunoassays. Nature 284:14–15

    Article  CAS  PubMed  Google Scholar 

  35. Potts JT (2005) Parathyroid hormone: past and present. J Endocrinol 187:311–325

    Article  CAS  PubMed  Google Scholar 

  36. Jüppner H, Potts JT Jr (2002) Immunoassays for the detection of parathyroid hormone. J Bone Miner Res 17(Suppl 2):N81–N86

    PubMed  Google Scholar 

  37. Nussbaum SR, Zahradnik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY, Keutmann HT, Wang CA, Potts JT Jr, Segre GV (1987) Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 33:1364–1367

    CAS  PubMed  Google Scholar 

  38. Jüppner H, Abou-Samra AB, Freeman M et al (1991) A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024–1026

    Article  PubMed  Google Scholar 

  39. Gardella T, Jüppner H, Brown E, Kronenberg H, Potts J Jr (2010) Parathyroid hormone and parathyroid hormone -related peptide in the regulation of calcium homeostasis and bone regulation. In: DeGroot L, Jameson J (eds) Endocrinology, 6th edn. W. B. Saunders Co., Philadelphia

    Google Scholar 

  40. Thakker RV (2001) Genetic developments in hypoparathyroidism. Lancet 357:974–976

    Article  CAS  PubMed  Google Scholar 

  41. Nesbit MA, Hannan FM, Howles SA, Babinsky VN, Head RA, Cranston T, Rust N, Hobbs MR, Heath H 3rd, Thakker RV (2013) Mutations affecting G-protein subunit alpha11 in hypercalcemia and hypocalcemia. N Engl J Med 368:2476–2486

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  42. Mannstadt M, Harris M, Bravenboer B, Chitturi S, Dreijerink KM, Lambright DG, Lim ET, Daly MJ, Gabriel S, Jüppner H (2013) Germline mutations affecting Galpha11 in hypoparathyroidism. N Engl J Med 368:2532–2534

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  43. Maeda A, Okazaki M, Baron DM et al (2013) Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH. Proc Natl Acad Sci U S A 110:5864–5869

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  44. Mannstadt M, Clarke BL, Vokes T et al (2013) Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Lancet Diabetes Endocrinol 1:275–283

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Mannstadt MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Italia

About this chapter

Cite this chapter

Mannstadt, M., Potts, J.T. (2015). The History: From Ivar Sandström to the Sequence of Parathyroid Hormone. In: Brandi, M., Brown, E. (eds) Hypoparathyroidism. Springer, Milano. https://doi.org/10.1007/978-88-470-5376-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-5376-2_1

  • Published:

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5375-5

  • Online ISBN: 978-88-470-5376-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics