Anticholinergics: Towards Selective Antimuscarinic Agents?

  • J. Rupreht
Conference paper


Molecular pharmacology has identified at least five distinct subtypes of acetylcholinergic receptors in the muscarine-receptor group. These receptors subserve a number of different physiological functions which may become adversely affected by use of non-specific antimuscarinic agents during anaesthesia. To target certain muscarinic receptors by highly selective acetylcholine (ACh) blocking agents have become preferable to classical antimuscarinic agents which may result in a number of unwanted side effects e.g. to protect the heart against neostigmine-induced bradycardia without excessively dry mouth.


Muscarinic Receptor Antimuscarinic Agent Autonomic Ganglion Scopolamine Hydrobromide Antimuscarinic Effect 
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© Springer-Verlag Italia 2000

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  • J. Rupreht

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