Abstract
Cutaneuos involvement with ulcers occurs in 10% of patients with cryoglobulinemia. Ulcers of the lower limbs are often painful and compromise the quality of life. A careful evaluation of ulcers is therefore mandatory, as is the exclusion of pre-existing arterial disease. Treatment consists of antibiotic swabs, careful cleaning, and appropriate dressing. The best approach is to treat the cryoglobulinemia, but in non-responders colchicine or the low antigen content diet can be useful, both therapeutically and in preventing ulcer formation. Approaches with neuroelectrical stimulation are currently being investigated.
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Pietrogrande, M. (2012). Active or Indolent Cutaneous Ulcers in Cryoglobulinemia: How Should They Be Treated?. In: Dammacco, F. (eds) HCV Infection and Cryoglobulinemia. Springer, Milano. https://doi.org/10.1007/978-88-470-1705-4_42
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DOI: https://doi.org/10.1007/978-88-470-1705-4_42
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