Active or Indolent Cutaneous Ulcers in Cryoglobulinemia: How Should They Be Treated?



Cutaneuos involvement with ulcers occurs in 10% of patients with cryoglobulinemia. Ulcers of the lower limbs are often painful and compromise the quality of life. A careful evaluation of ulcers is therefore mandatory, as is the exclusion of pre-existing arterial disease. Treatment consists of antibiotic swabs, careful cleaning, and appropriate dressing. The best approach is to treat the cryoglobulinemia, but in non-responders colchicine or the low antigen content diet can be useful, both therapeutically and in preventing ulcer formation. Approaches with neuroelectrical stimulation are currently being investigated.


Autonomic Neuropathy Ulcer Healing Alginate Product Diabetic Ulcer Cutaneous Ulcer 


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© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Dipartimento di Medicina, Chirurgia e OdontoiatriaUniversity of MilanMilanItaly

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