HCV Infection and Cryoglobulinemia

  • Franco Dammacco

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Hepatitis C Virus Infection and the Role of the Immune System

    1. Front Matter
      Pages 9-9
    2. Franco Dammacco, Domenico Sansonno
      Pages 1-8
    3. Edgar D. Charles, Lynn B. Dustin, Charles M. Rice
      Pages 11-19
    4. Lynn B. Dustin
      Pages 21-36
    5. Vito Racanelli, Claudia Brunetti
      Pages 37-41
    6. Corrado Betterle, Fabio Presotto
      Pages 43-51
  3. Cellular Compartments of HCV Infection (and Replication)

    1. Front Matter
      Pages 53-53
    2. Franco Dammacco, Vito Racanelli
      Pages 63-68
    3. Tram N. Q. Pham, Tomasz I. Michalak
      Pages 69-75
  4. Cryoglobulinemia and the Complement System

    1. Front Matter
      Pages 77-77
    2. Jürg A. Schifferli, Marten Trendelenburg
      Pages 79-83
    3. Marten Trendelenburg
      Pages 85-89
    4. Domenico Sansonno, Loredana Sansonno, Franco Dammacco
      Pages 91-96
  5. Structural and Genetic Features, Cytokines and Chemokines in Cryoglobulinemia

About this book


In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These “cryoglobulins” were responsible for the corresponding clinical condition “cryoglobulinemia.” Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepatitis C virus infection.

The book is unique in its detailed presentation and fundamental approach. Highly qualified authors have contributed critical articles reviewing significant developments in our understanding of and therapeutic approach to HCV infection and cryoglobulinemia. The text is accompanied by striking color images and illustrations and highly informative tables.

This comprehensive review of a systemic disease with a complex etiology is a valuable source of up-to-date, expert information not only for basic scientists and specialists in several disciplines but also for general practitioners as well as graduate and post-graduate students in clinical and medical research.


Autoimmunity Cryoglobulinemia HCV Immune Complex Diseases Malignant Lymphoma

Editors and affiliations

  • Franco Dammacco
    • 1
  1. 1., Department of Internal Medicine and ClinUniversity of BariBariItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-88-470-1705-4
  • Copyright Information Springer-Verlag Italia 2012
  • Publisher Name Springer, Milano
  • eBook Packages Medicine
  • Print ISBN 978-88-470-1704-7
  • Online ISBN 978-88-470-1705-4
  • About this book
Industry Sectors