HCV Infection and Cryoglobulinemia

1. Front Matter

   Pages i-xvii

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2. Hepatitis C Virus Infection and the Role of the Immune System

   1. Front Matter

      Pages 9-9

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   2. Introductory Remarks

      • Franco Dammacco, Domenico Sansonno

      Pages 1-8

   3. Natural History, Pathogenesis, and Prevention of HCV Infection

      • Edgar D. Charles, Lynn B. Dustin, Charles M. Rice

      Pages 11-19

   4. Immune Control of HCV Infection

      • Lynn B. Dustin

      Pages 21-36

   5. B Cell Activation: General to HCV-Specific Considerations

      • Vito Racanelli, Claudia Brunetti

      Pages 37-41

   6. Organ-Specific Autoimmunity in HCV-Positive Patients

      • Corrado Betterle, Fabio Presotto

      Pages 43-51

3. Cellular Compartments of HCV Infection (and Replication)

   1. Front Matter

      Pages 53-53

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   2. HCV and Blood Cells: How Can We Distinguish Infection from Association?

      • Lynn B. Dustin, Charles M. Rice

      Pages 55-62

   3. Mechanisms of Cell Entry of Hepatitis C Virus

      • Franco Dammacco, Vito Racanelli

      Pages 63-68

   4. HCV Infection of Hematopoietic and Immune Cell Subsets

      • Tram N. Q. Pham, Tomasz I. Michalak

      Pages 69-75

4. Cryoglobulinemia and the Complement System

   1. Front Matter

      Pages 77-77

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   2. Cryoglobulinemia and Chronic HCV Infection: An Evolving Story

      • Jürg A. Schifferli, Marten Trendelenburg

      Pages 79-83

   3. The Complement System in Cryoglobulinemia

      • Marten Trendelenburg

      Pages 85-89

   4. The Pivotal Role of C1qR in Mixed Cryoglobulinemia

      • Domenico Sansonno, Loredana Sansonno, Franco Dammacco

      Pages 91-96

5. Structural and Genetic Features, Cytokines and Chemokines in Cryoglobulinemia

   1. Front Matter

      Pages 97-97

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   2. Mixed Cryoglobulinemia (MC) Cross-Reactive Idiotypes (CRI): Structural and Clinical Significance

      • Peter D. Gorevic

      Pages 99-105

   3. Molecular Insights into the Disease Mechanisms of Type II Mixed Cryoglobulinemia

      • Valli De Re, Marica Garziera

      Pages 107-111

   4. The Role of VCAM-1 in the Pathogenesis of Hepatitis-C-Associated Mixed Cryoglobulinemia Vasculitis

      • Gilles Kaplanski

      Pages 113-117

   5. Up-Regulation of B-Lymphocyte Stimulator (BLyS) in Patients with Mixed Cryoglobulinemia

      • Martina Fabris, Salvatore De Vita

      Pages 119-126

The first observation of cold-induced precipitation of serum proteins dates back to 1933, when Wintrobe and Buell first described an unusual case of multiple myeloma in a woman whose serum reversibly precipitated at cold temperatures. In 1947 Lerner and Watson showed cold-precipitable proteins to be gammaglobulins and called them ‘cryoglobulins’ and the corresponding clinical condition ‘cryoglobulinemia’. Meltzer and Franklin in 1966 provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia, showed that they consisted of two different globulin components and, because of the ignorance on its etiology, called this clinical condition ‘essential mixed cryoglobulinemia’. For almost 20 years progress has been rather slow in this field, but when at the end of the ‘80s it finally became possible to detect the occurrence in the serum of antibodies to the hepatitis C virus (HCV), many groups in Europe and the United States almost simultaneously reported that a high proportion of ‘essential’ cryoglobulinemias are in fact associated with HCV infection. This hallmark has resulted in a new impetus and great enthusiasm in carrying out new researches made possible by the awareness that cryoglobulinemia is to be considered an undisputable extrahepatic manifestation of HCV infection. In addition, the evidence that HCV has tropism for hepatocytes and lymphocytes has stimulated new approaches to the autoimmune phenomena and the potential transformation in non-Hodgkin’s lymphomas which not infrequently can be discovered in these patients. The same applies to the obvious therapeutic implications, once the association between HCV infection and mixed cryoglobulinemia has been firmly established. It was thus felt that times were ripe to produce a state-of-the-art survey of the multi-faceted picture of cryoglobulinemia. This book is indeed unique in the detail of its presentation, its completeness and its fundamental approach to the subject. The most qualified authors have been invited to contribute critical articles reviewing significant developments related to each of the eight sections in which the whole treatment has been divided: from basic mechanisms governing interactions between HCV and the immune system to the immunochemical characterization of cryoglobulins and the frequently concomitant serological abnormalities; from genetic features and the role of certain cytokines and chemokines to the cellular compartments of HCV infection and replication; from the clinical manifestations of cryoglobulinemic patients and their potential susceptibility to develop non-Hodgkin’s lymphoma to conventional treatment of the syndrome and the newer, promising therapeutic advances. The reader will appreciate the immediacy of style, the striking illustrations, and the color plates. In addition, the comprehensive review of a systemic disease such as cryoglobulinemia will interest basic scientists and specialists involved in several disciplines, including internal medicine, hepatology, hematology, oncology, infectious diseases, rheumatology, nephrology and dermatology. General practitioners, graduate and post-graduate students will also find in this book an irreplaceable source of update in this fascinating field.

• Autoimmunity
• Cryoglobulinemia
• HCV
• Immune Complex Diseases
• Malignant Lymphoma
• hepatology
• infectious diseases

• , Department of Internal Medicine and Clin, University of Bari, Bari, Italy

  Franco Dammacco

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