Abstract
Classification criteria that have been developed with an accepted statistical methodology are presently lacking for cryoglobulinemic syndrome or vasculitis (CV). However, they are essential for research and epidemiologic studies, and in turn for clinical practice. Earlier CV classification criteria were elaborated by individual experts or a panel of experts, such as those proposed in 1995 by the GISC (Italian Study Group on Cryoglobulinemia). New, albeit still preliminary classification criteria for CV were recently developed by a co-operative international study drawing upon a standardized methodology based on a large number of real cases/controls (n = 925). These criteria were subsequently shown to have a high specificity (93.6%) and good sensitivity (88.5%) for CV. Formal validation involving experts from a larger number of countries is now needed.
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References
Meltzer M, Franklin EC (1966) Cryoglobulinemia – a study of twenty-nine patients. I. IgG and IgM cryoglobulins and factors affecting cryoprecipitability. Am J Med 40(6):828–836
Gorevic PD, Frangione B (1991) Mixed cryoglobulinemia cross-reactive idiotypes: implications for the relationship of MC to rheumatic and lymphoproliferative diseases. Semin Hematol 28(2):79–94
De Vita S, De Re V, Gasparotto D et al (2000) Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. Arthritis Rheum 43(1):94–102
Ferri C, Greco F, Longombardo G et al (1991) Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. Arthritis Rheum 34:1606–1610
Agnello V, Chung RT, Kaplan LM (1992) A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 327(21):1490–1495
Johnson SR, Goek ON, Singh-Grewal D et al (2007) Classification criteria in rheumatic diseases: a review of methodologic properties. Arthritis Rheum 57:1119–1133
Dougados M, Gossec L (2007) Classification criteria for rheumatic diseases: why and how? Arthritis Rheum 57: 1112–1115
Mukhtyar C, Guillevin L, Cid MC et al (2009) European Vasculitis Study Group. EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 68:310–317
Invernizzi F, Pietrogrande M, Sagramoso B (1995) Classification of the cryoglobulinemic syndrome. Clin Exp Rheumatol 13(Suppl 13):S123–S128
Vitali C, Bombardieri S, Moutsopoulos HM et al (1993) Preliminary criteria for the classification of Sjögren’s syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 36:340–347
Vitali C, Bombardieri S, Moutsopoulos HM et al (1996) Assessment of the European classification criteria for Sjögren’s syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjögren’s Syndrome. Ann Rheum Dis 55:116–121
Vitali C, Bombardieri S, Jonsson R et al (2002) European Study Group on Classification Criteria for Sjögren’s Syndrome. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558
Lamprecht P (2004) The cryoglobulinemic syndrome – report from the workshop on classification and on the 10th conference of the Italian Society for the Treatment of Cryoglobulinemia, Modena, 29 Sept, 2003. Z Rheumatol 63:235–238
De Vita S, Soldano F, Isola M et al (2010) Preliminary classification criteria for the cryoglobulinemic syndrome. Ann Rheum Dis 69(Suppl 3):77
De Vita S, Soldano F, Isola M et al (2010) Preliminary classification criteria for the cryoglobulinemic syndrome. Arthritis Rheum 62(Suppl 10):S851–S852
De Vita S, Soldano F, Isola M et al (2011) Preliminary classification criteria for the cryoglobulinemic vasculitis. Ann Rheum Dis 70(7):1183–1190
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De Vita, S., Quartuccio, L. (2012). Classification of Cryoglobulinemic Vasculitis. In: Dammacco, F. (eds) HCV Infection and Cryoglobulinemia. Springer, Milano. https://doi.org/10.1007/978-88-470-1705-4_20
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DOI: https://doi.org/10.1007/978-88-470-1705-4_20
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