Abstract
Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) of unknown etiology that predominantly affects young adults. It can involve any part of the gastrointestinal tract, most commonly, the terminal ileum, the colon, or both, and its course is characterized by exacerbations and remissions. It may also involve organs outside the gastrointestinal tract. Some of these extraintestinal manifestions are true components of CD while others are complications caused by malnutrition, chronic inflammation, or the side effects of therapy, which make the differential diagnosis accordingly difficult [1,2]. Moreover, the extraintestinal manifestations may or may not correlate with disease activity but nonetheless can have a high impact on the quality of life, morbidity, and mortality of CD patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Solis Herruzo JA, Solis-Munoz P (2007) Hepatobiliary manifestations of inflammatory bowel disease. Rev Esp Enferm Dig 99:525–542
Weismuller TJ, Wedemeyer J, Kubicka S et al (2008) The challenges in primarysclerosing cholangitis — Aetiopathogenesis, autoimmunity, management and malignancy. J Hepatol 48:38–57
Thomas CH (1873) Ulceration of the colon with a much enlarged fatty liver. Trans Pathol Soc Phil 4:87–88
Lister JD (1899) A specimen of diffuse ulcerative colitis with secondary diffuse hepatitis. Trans Pathol Soc Lon 50:130–134
Perrett AD, Higgins G, Johnston HH et al (1971) The liver in Crohn’s disease. Q J Med 40:187–209
Atkinson AJ, Carrol WW (1964) Sclerosing cholangitis association with regional enteritis. JAMA 188:183–184
Rasmussen HH, Fallingborg JF, Mortensen PB et al (1997) Hepatobiliary dysfunction and PSC in patients with Crohn’s disease. Scan J Gastroenterol 32:604–610
Okada H, Mizuno M, Yamamoto K, Tsuji T (1966) Primary sclerosing cholangitis in Japanese patients: association with IBD. Acta Med Okayama 50:227–235
Chapman RW, Angus PW (1999) The effect of gastrointestinal disease on the liver and biliary tract. In: Oxford textbook of clinical hepatology. Oxford medical publications. Oxford University Press, Oxford New York Tokyo, pp 1686–1691
Pratt DS, Kaplan MM (2000) Evaluation of abnormal liver-enzime results in asymptomatic patients. N Engl J Med 342:1266–1271
Delbert (1924) Bull Mem Soc Chir Paris 50:1144–1146
Angulo P, Maor-Kendler Y, Lindor KD (2002) Small-duct PSC: a long-term follow-up study. Hepatology 35:1494–1500
Escorell A, Pares A, Rodes J et al (1994) Epidemiology of primary sclerosing cholangitis in Spain. J Hepatol 21:789–791
Okolicsanyi L, Fabris L, Viaggi S et al (1996) Primary sclerosing cholangitis: clinical presentation, Natural history of prognostic variables: an italian multicenter study. Eur J Gastroenterol Hepatol 8:685–691
Tanaka A, Takamori Y, Toda G et al (2008) Outcome and prognostic factors of 391 Japanese patients with primary sclerosing cholangitis. Liver Int 28(7):983–998
Broome U, Olsson R, Loof L et al (1966) Natural history and prognostic factors in 305 Swedish patients with PSC. Gut 38:610–615
Chapman RW, Arborgh BA, Rhodes JM et al (1980) PSC: review of its clinical features, cholangiography, and hepatic histology. Gut 21:870–877
MacCarty RL, LaRusso NF, Wiesner RH, Ludwig J (1983) PSC: findings on cholangiography and pancreatography, Radiology 149:39–44
Ludwig J, Viggiano RT, McGill DB (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed. Mayo Clinic Proc 55:342–348
Margalit M, Elinav H, Han Y, Shalit M (2004) Liver abscess in IBD. J Gastr Hepatol 19:1338–1342
Fraquelli M, Losco A, Visentin S et al (2001) Gallstone disease and related risk factors in patients with CD. Arch Intern Med 161:2201–2204
Dowling RH, Bell DG, White J (1972) Lithogenic bile in patients with ileal dysfunction. Gut 13:415–420
Millonig G, Kern M, Ludwiczek O et al (2006) subfulminant hepatitis B after infliximab in CD; need for HBV screening? World J Gastroenterol 12:974–976
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Italia
About this chapter
Cite this chapter
Nauri, L. (2010). Hepatopathologies. In: Tersigni, R., Prantera, C. (eds) Crohn’s Disease. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1472-5_21
Download citation
DOI: https://doi.org/10.1007/978-88-470-1472-5_21
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1471-8
Online ISBN: 978-88-470-1472-5
eBook Packages: MedicineMedicine (R0)