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Cardiac Functional Effects of 3-iodothyronamine, a New Endogenous Thyroid Hormone Derivative

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Thyroid and Heart Failure

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Abstract

Thyronamines are decarboxylated derivatives of thyroid hormone. 3-Iodothyronamine (T1AM) has been detected in blood and in several tissues. where it is likely produced from thyroid hormone by the consequent action of aromatic amino acid decarboxylase and deiodinases. In vitro, high-affinity interaction has been observed between T1AM and a novel G-protein-coupled receptor known as trace-amine-associated receptor 1 (TAAR1). TAAR1 and other receptors of this family are expressed in several tissues, including the heart. Functional effects have been observed after administration of exogenous T1AM: in the isolated heart, a negative inotropic and chronotropic action was produced, and the resistance to ischemic injury was increased, possibly as a consequence of an action on intracellular calcium homeostasis. Extracardiac effects include reduction of body temperature, increased lipid versus carbohydrate metabolism, modulation of insulin secretion, and inhibition of neuronal catecholamine reuptake. T1AM may play an important physiological or pathophysiological role, and this signaling system might allow the development of new therapeutic agents.

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Authors and Affiliations

  1. University of Pisa, Pisa, Italy

    Riccardo Zucchi MD, PhD (Professor of Biochemistry)

  2. Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy

    Sandra Ghelardoni PhD & Grazia Chiellini PhD

  3. Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison, Madison, WI, USA

    Grazia Chiellini PhD

Authors
  1. Riccardo Zucchi MD, PhD
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  2. Sandra Ghelardoni PhD
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  3. Grazia Chiellini PhD
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Editor information

Editors and Affiliations

  1. C.N.R. Clinical Physiology Institute, S. Cataldo Research Campus, Pisa, Italy

    Giorgio Iervasi  & Alessandro Pingitore  & 

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© 2009 Springer-Verlag Italia

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Zucchi, R., Ghelardoni, S., Chiellini, G. (2009). Cardiac Functional Effects of 3-iodothyronamine, a New Endogenous Thyroid Hormone Derivative. In: Iervasi, G., Pingitore, A. (eds) Thyroid and Heart Failure. Springer, Milano. https://doi.org/10.1007/978-88-470-1143-4_6

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  • DOI: https://doi.org/10.1007/978-88-470-1143-4_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1142-7

  • Online ISBN: 978-88-470-1143-4

  • eBook Packages: MedicineMedicine (R0)

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