Thyroid and Heart Failure

From Pathophysiology to Clinics

  • Giorgio Iervasi
  • Alessandro Pingitore

Table of contents

  1. Front Matter
    Pages I-XXI
  2. Heart Failure and Thyroid: General Aspects

  3. Basic Aspects of Thryroid Hormone and Cardiovascular System Interrelationships in Normal and in Failing Heart

    1. Front Matter
      Pages 43-43
    2. Riccardo Zucchi, Sandra Ghelardoni, Grazia Chiellini
      Pages 55-65
    3. Koichiro Kinugawa, Mark Y. Jeong, Michael R. Bristow, Carlin S. Long
      Pages 79-88
    4. Yuefeng Chen, A. Martin Gerdes
      Pages 119-130
    5. Constantinos Pantos, Iordanis Mourouzis, Dennis V. Cokkinos
      Pages 131-148
  4. Clinical Aspects

    1. Front Matter
      Pages 149-149
    2. Avantika C. Waring, Anne R. Cappola
      Pages 151-165
    3. Giorgio Iervasi, Laura Sabatino, Giuseppina Nicolini
      Pages 179-190
    4. Carmine Zoccali, Francesca Mallamaci
      Pages 191-201
  5. Treatment: Present and Future Options

    1. Front Matter
      Pages 213-213
    2. Alessandro Pingitore, Vincenzo Lionetti, Francesca Forini
      Pages 225-241
  6. Back Matter
    Pages 261-264

About this book


Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.


Bypass cardiac function cardiovascular heart homeostasis hormone hormone receptors molecular biology pathophysiology physiology receptor signaling surgery therapy thyroid hormone treatment

Editors and affiliations

  • Giorgio Iervasi
    • 1
  • Alessandro Pingitore
    • 1
  1. 1.C.N.R. Clinical Physiology InstituteS. Cataldo Research CampusPisaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Milan 2009
  • Publisher Name Springer, Milano
  • eBook Packages Medicine
  • Print ISBN 978-88-470-1142-7
  • Online ISBN 978-88-470-1143-4
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals