Prolactin and Somatostatin Responses to Antidepressant Therapy



Neuropeptides have been implicated in the physiology and pathophysiology of stress responses and therefore may play an important role in the pathogenesis of affective disorders such as major depressive disorder (MDD). The data presented in this chapter demonstrate the role of prolactin (PRL) and somatostatin (STT) in the pathology and pharmacotherapy of MDD, focusing particularly on the response to antidepressant treatment, and compare the available data with the results obtained in our laboratory using in vitro model (HEK293 cells line) and the well-validated chronic mild stress (CMS) animal model of MDD.


Major Depressive Disorder Anterior Cingulate Cortex Chronic Mild Stress Seasonal Affective Disorder GPCR Heterodimers 
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© Springer India 2016

Authors and Affiliations

  1. 1.Department of PharmacologyInstitute of Pharmacology Polish Academy of SciencesKrakówPoland

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