Melatonin, Neuroprotective Agents and Antidepressant Therapy

  • Francisco López-Muñoz
  • Venkataramanujam Srinivasan
  • Domenico de Berardis
  • Cecilio Álamo
  • Takahiro A. Kato

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Francisco López-Muñoz, Fernando Marín, Cecilio Álamo
    Pages 1-23
  3. Francisco López-Muñoz, Francisco J. Povedano, Cecilio Álamo
    Pages 25-42
  4. J. M. Bumb, Ingo S. Nölte
    Pages 43-53
  5. Agata Carpentieri, Vanessa Areco, Gabriela Díaz de Barboza, María Angélica Rivoira, Solange Guizzardi, Nori Tolosa de Talamoni
    Pages 55-64
  6. Omur Gulsum Deniz, Aysın Pınar Turkmen, Mehmet Emin Onger, Berrin Zuhal Altunkaynak, Suleyman Kaplan
    Pages 65-75
  7. Giovanni Polimeni, Claudio Guarneri, Salvatore Cuzzocrea
    Pages 77-89
  8. Eva Ramos, Paloma Patiño, José Luis Marco-Contelles, Ramón Cacabelos, Alejandro Romero
    Pages 91-99
  9. Piyarat Govitrapong, Kasima Ekthuwapranee, Nootchanart Ruksee, Parichart Boontem
    Pages 101-115
  10. Venkataramanujam Srinivasan, Domenico de Berardis, Michele Fornaro, Francisco López-Muñoz, Timo Partonen, Rahimah Zakaria
    Pages 117-127
  11. Murat Terzi, Mehmet Emin Onger, Aysin Pınar Turkmen, Sefa Ersan Kaya, Arife Ahsen Kaplan, Berrin Zuhal Altunkaynak et al.
    Pages 137-149
  12. Andrei Pereira Pernambuco, Marina de Barros Pinheiro, Débora d’ Ávila Reis
    Pages 151-163
  13. Pınar Atukeren, Hafize Uzun
    Pages 165-175
  14. René Pita, Eva Ramos, José Luis Marco-Contelles, Alejandro Romero
    Pages 177-191
  15. Pilar García-García, Francisco López-Muñoz, Cecilio Álamo
    Pages 193-202
  16. Venkataramanujam Srinivasan, Rahimah Zakaria, Domenico de Berardis, Francisco López-Muñoz, Mohd Jamil Yaacob, Zahiruddin Othman et al.
    Pages 203-217
  17. Venkataramanujam Srinivasan, Domenico de Berardis, Michele Fornaro, Francisco Lopez-Muñoz, Rahimah Zakaria, Mohd Jamil Yaacob et al.
    Pages 219-228
  18. Trevor R. Norman
    Pages 229-247
  19. Stephan Moratti, Alberto Fernández, Rosa Jurado, Gabriel Rubio
    Pages 249-271

About this book


This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities   in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. 


Agomelatine Chronobiology of mood disorders Hippocampal neurogenesis, depression and antidepressants Melatonergic drugs in sleep and depressive disorders Melatonin and mood disorders

Editors and affiliations

  • Francisco López-Muñoz
    • 1
  • Venkataramanujam Srinivasan
    • 2
  • Domenico de Berardis
    • 3
  • Cecilio Álamo
    • 4
  • Takahiro A. Kato
    • 5
  1. 1.Vice-Rectorate for Research and SciCamilo José Cela University Vice-Rectorate for Research and SciMadridSpain
  2. 2.International Medical Sciences Research Study CenterSri Sathya Sai Medical Educational & Research FoundationCoimbatoreIndia
  3. 3.Department of Neurosciences and ImaUniversity of Chieti Department of Neurosciences and ImaItalyItaly
  4. 4.Department of Biomedical Sciences (Pharmacology Area)University of AlcaláMadridSpain
  5. 5.Department of NeuropsychiatryKyushu UniversityFukuokaJapan

Bibliographic information

  • DOI
  • Copyright Information Springer India 2016
  • Publisher Name Springer, New Delhi
  • eBook Packages Medicine
  • Print ISBN 978-81-322-2801-1
  • Online ISBN 978-81-322-2803-5
  • About this book
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