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Melatonin, Neuroprotective Agents and Antidepressant Therapy

  • Francisco López-Muñoz
  • Venkataramanujam Srinivasan
  • Domenico de Berardis
  • Cecilio Álamo
  • Takahiro A. Kato

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Francisco López-Muñoz, Fernando Marín, Cecilio Álamo
    Pages 1-23
  3. Francisco López-Muñoz, Francisco J. Povedano, Cecilio Álamo
    Pages 25-42
  4. J. M. Bumb, Ingo S. Nölte
    Pages 43-53
  5. Agata Carpentieri, Vanessa Areco, Gabriela Díaz de Barboza, María Angélica Rivoira, Solange Guizzardi, Nori Tolosa de Talamoni
    Pages 55-64
  6. Omur Gulsum Deniz, Aysın Pınar Turkmen, Mehmet Emin Onger, Berrin Zuhal Altunkaynak, Suleyman Kaplan
    Pages 65-75
  7. Giovanni Polimeni, Claudio Guarneri, Salvatore Cuzzocrea
    Pages 77-89
  8. Eva Ramos, Paloma Patiño, José Luis Marco-Contelles, Ramón Cacabelos, Alejandro Romero
    Pages 91-99
  9. Piyarat Govitrapong, Kasima Ekthuwapranee, Nootchanart Ruksee, Parichart Boontem
    Pages 101-115
  10. Venkataramanujam Srinivasan, Domenico de Berardis, Michele Fornaro, Francisco López-Muñoz, Timo Partonen, Rahimah Zakaria
    Pages 117-127
  11. Murat Terzi, Mehmet Emin Onger, Aysin Pınar Turkmen, Sefa Ersan Kaya, Arife Ahsen Kaplan, Berrin Zuhal Altunkaynak et al.
    Pages 137-149
  12. Andrei Pereira Pernambuco, Marina de Barros Pinheiro, Débora d’ Ávila Reis
    Pages 151-163
  13. Pınar Atukeren, Hafize Uzun
    Pages 165-175
  14. René Pita, Eva Ramos, José Luis Marco-Contelles, Alejandro Romero
    Pages 177-191
  15. Pilar García-García, Francisco López-Muñoz, Cecilio Álamo
    Pages 193-202
  16. Venkataramanujam Srinivasan, Rahimah Zakaria, Domenico de Berardis, Francisco López-Muñoz, Mohd Jamil Yaacob, Zahiruddin Othman et al.
    Pages 203-217
  17. Venkataramanujam Srinivasan, Domenico de Berardis, Michele Fornaro, Francisco Lopez-Muñoz, Rahimah Zakaria, Mohd Jamil Yaacob et al.
    Pages 219-228
  18. Trevor R. Norman
    Pages 229-247
  19. Stephan Moratti, Alberto Fernández, Rosa Jurado, Gabriel Rubio
    Pages 249-271
  20. Felice Iasevoli, Livia Avvisati, Valentina Gilardi, Gianmarco Latte, Emiliano Prinzivalli, Domenico de Berardis et al.
    Pages 273-295
  21. Robert Gonzalez
    Pages 297-317
  22. Timo Partonen
    Pages 319-334
  23. Alan B. Douglass, Marcus Ward, Timothy Roerhrs, Cynthia L. Arfken, Nash N. Boutrous
    Pages 347-356
  24. Francisco López-Muñoz, Cecilio Álamo
    Pages 365-383
  25. Dimos Dimelis, Xenia Gonda, Konstantinos N. Fountoulakis
    Pages 385-420
  26. Francisco López-Muñoz, Cecilio Álamo, Pilar García-García
    Pages 421-444
  27. Cecilio Álamo, Francisco López-Muñoz, Pilar García-García
    Pages 445-463
  28. Gianluca Serafini, Paola Solano, Mario Amore
    Pages 477-499
  29. Xenia Gonda, Zoltan Rihmer, Peter Dome
    Pages 501-522
  30. Manuel Sebastián-Aldeanueva, Francisco López-Muñoz, José Antonio Guerra, Cecilio Álamo
    Pages 523-532
  31. Ana Isabel Wu-Chou, Yu-Li Liu, Winston W. Shen
    Pages 533-543
  32. Ramón Cacabelos, Clara Torrellas, Francisco López-Muñoz
    Pages 545-609
  33. Masahiro Ohgidani, Takahiro A. Kato, Yoshito Mizoguchi, Hideki Horikawa, Akira Monji, Shigenobu Kanba
    Pages 611-620
  34. Emmanuel Darcq, Paul Chu-Sin-Chung, Brigitte L. Kieffer, Pierre-Eric Lutz
    Pages 631-653
  35. Agata Faron-Górecka, Kinga Szafran-Pilch
    Pages 655-666
  36. Julio Cesar Morales-Medina, Shannah K. Witchey, Heather K. Caldwell
    Pages 667-685
  37. Derek K. Tracy, Caroline Caddy, Sukhwinder S. Shergill
    Pages 687-706
  38. Derek K. Tracy, Valentina Casetti, Arann R. Rowe, Louise Mercer, Sukhwinder S. Shergill
    Pages 707-730
  39. Derek K. Tracy, Nicola Smallcombe, Farah Tiwana, Judith Fosbraey, Kyra-Verena Sendt, Sukhwinder S. Shergill
    Pages 731-750
  40. Gregers Wegener, Sâmia R. L. Joca
    Pages 765-792
  41. Sofia Avissar, Moran Golan, Valeria Feinshtein, Siyona Kolatkar, Doron Fux, Gabriel Schreiber
    Pages 793-804
  42. Zhuoyou Chen, Xifei Yang, Ying Xu, Han-Ting Zhang
    Pages 805-823
  43. Berrin Zuhal Altunkaynak, Mehmet Emin Onger, Aysin Pınar Turkmen, Kıymet Kubra Yurt, Gamze Altun, Murat Yuce et al.
    Pages 825-845
  44. Domenico de Berardis, Laura Orsolini, Felice Iasevoli, Carmine Tomasetti, Monica Mazza, Alessandro Valchera et al.
    Pages 847-854

About this book

Introduction

This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities   in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. 

Keywords

Agomelatine Chronobiology of mood disorders Hippocampal neurogenesis, depression and antidepressants Melatonergic drugs in sleep and depressive disorders Melatonin and mood disorders

Editors and affiliations

  • Francisco López-Muñoz
    • 1
  • Venkataramanujam Srinivasan
    • 2
  • Domenico de Berardis
    • 3
  • Cecilio Álamo
    • 4
  • Takahiro A. Kato
    • 5
  1. 1.Vice-Rectorate for Research and SciCamilo José Cela University Vice-Rectorate for Research and SciMadridSpain
  2. 2.International Medical Sciences Research Study CenterSri Sathya Sai Medical Educational & Research FoundationCoimbatoreIndia
  3. 3.Department of Neurosciences and ImaUniversity of Chieti Department of Neurosciences and ImaItalyItaly
  4. 4.Department of Biomedical Sciences (Pharmacology Area)University of AlcaláMadridSpain
  5. 5.Department of NeuropsychiatryKyushu UniversityFukuokaJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-81-322-2803-5
  • Copyright Information Springer India 2016
  • Publisher Name Springer, New Delhi
  • eBook Packages Medicine
  • Print ISBN 978-81-322-2801-1
  • Online ISBN 978-81-322-2803-5
  • Buy this book on publisher's site
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