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Oxidative Stress in Low Birth Weight Newborns

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Free Radicals in Human Health and Disease

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Abstract

Free radical damage has been recognized to be a common pathogenic mechanism of many neonatal diseases. An excessive and/or sustained increase in free radical production associated with diminished efficacy of the antioxidant defense systems results in oxidative stress, which occurs in many pathologic processes and contributes significantly to disease and can be the key link between size at birth and increased morbidity later in life. Low birth weight is closely associated with fetal and neonatal mortality and morbidity, inhibited growth and cognitive development, and chronic diseases later in life. Low birth weight is considered the primary factor associated with a poor perinatal outcome of maternal preeclampsia/eclampsia and premature birth. High oxidative stress and low level of enzymatic antioxidants and antioxidant nutrients such as vitamins A, E, and C, zinc, copper, and selenium and antioxidant status might be increasing the risk of pathogenesis of major complications in low birth weight newborns.

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Authors and Affiliations

  1. Department of Biophysics, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Reena Negi, Deepti Pande, Kanchan Karki & Hari D. Khanna

  2. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Ashok Kumar

  3. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India

    Ranjana S. Khanna

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  4. Ashok Kumar
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  5. Ranjana S. Khanna
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  6. Hari D. Khanna
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Correspondence to Hari D. Khanna .

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  1. Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India

    Vibha Rani

  2. School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

    Umesh Chand Singh Yadav

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Negi, R., Pande, D., Karki, K., Kumar, A., Khanna, R.S., Khanna, H.D. (2015). Oxidative Stress in Low Birth Weight Newborns. In: Rani, V., Yadav, U. (eds) Free Radicals in Human Health and Disease. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2035-0_15

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