Rapid Synthesis of Oligosaccharides: Resin Capture-Release Strategy
A number of methodologies for efficient and selective O-glycoside bond formation have been successfully developed. Using these methods, syntheses of complex oligosaccharides have been achieved. However, chemical synthesis of glycoprotein-derived oligosaccharide or their derivative is technically demanding and highly time-consuming. In order that synthetic chemistry is going to function as the driving force in glycobiology, speeding up and automation are the key issues (Seeberger and Haase 2000).
KeywordsPolymer Support Combine Organic Layer Release Strategy Ethyl Chloroformate Oligosaccharide Synthesis
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