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Rapid Synthesis of Oligosaccharides: Resin Capture-Release Strategy

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Experimental Glycoscience

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Abstract

A number of methodologies for efficient and selective O-glycoside bond formation have been successfully developed. Using these methods, syntheses of complex oligosaccharides have been achieved. However, chemical synthesis of glycoprotein-derived oligosaccharide or their derivative is technically demanding and highly time-consuming. In order that synthetic chemistry is going to function as the driving force in glycobiology, speeding up and automation are the key issues (Seeberger and Haase 2000).

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References

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Author information

Authors and Affiliations

  1. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yukishige Ito & Shinya Hanashima

  2. CREST, JST, Kawaguchi, saitama, 332-1102, Japan

    Yukishige Ito & Shinya Hanashima

Authors
  1. Yukishige Ito
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  2. Shinya Hanashima
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Editor information

Editors and Affiliations

  1. Department of Disease Glycomics, Research Institute for Microbial Diseases, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) (Professor)

  2. Systems Glycobiology Group, Advanced Science Institute, RIKEN, Wako, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) (Professor)

  3. Institute of Glycotechnology, Future Science and Technology Joint Research Center, Tokai University, Hiratsuka, Kanagawa, 259-1292, Japan

    Akemi Suzuki M.D., Ph.D. (Professor) (Professor)

  4. RIKEN Discovery Research Institute, Synthetic Cellular Chemistry Laboratory, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yukishige Ito Ph.D. (Chief Researcher) (Chief Researcher)

  5. Research Center for Medical Glycoscience, Advanced Industrial Science and Technology, AIST Tsukuba, Central 2, Tsukuba, Ibaraki, 305-8568, Japan

    Hisashi Narimatsu M.D., Ph.D.

  6. Research Center for Glycobiotechnology, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan

    Toshisuke Kawasaki Ph.D. (Professor) (Professor)

  7. Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan

    Sumihiro Hase Ph.D. (Professor) (Professor)

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Ito, Y., Hanashima, S. (2008). Rapid Synthesis of Oligosaccharides: Resin Capture-Release Strategy. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77924-7_53

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