Abstract
Glycosaminoglycans (GAGs), the glycan part of the proteoglycan, are classified into several categories based on the type of the so-called “repeating disaccharide” moieties which consist of hexosamine and hexuronic acid. The repeating disaccharide region occupies most of the GAG. A variety of the GAG biological activities is controlled by the complex, but a minute structure of the repeating oligosaccharides including the regiospecific sulfate groups. GAGs obtained from nature have heterogeneous structures. On the other hand, chemically synthesized GAGs have well-defined structures in a molecular level, and sufficient amounts can be supplied. To study the chemical, biological, medical as well as physical performance of the GAGs, a synthetic approach is strongly recommended. This chapter describes the synthesis of the GAG oligosaccharides focusing on the repeating region.
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Tamura, Ji. (2008). Glycosaminoglycans. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77924-7_48
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DOI: https://doi.org/10.1007/978-4-431-77924-7_48
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77923-0
Online ISBN: 978-4-431-77924-7
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