• Jun-ichi Tamura


Glycosaminoglycans (GAGs), the glycan part of the proteoglycan, are classified into several categories based on the type of the so-called “repeating disaccharide” moieties which consist of hexosamine and hexuronic acid. The repeating disaccharide region occupies most of the GAG. A variety of the GAG biological activities is controlled by the complex, but a minute structure of the repeating oligosaccharides including the regiospecific sulfate groups. GAGs obtained from nature have heterogeneous structures. On the other hand, chemically synthesized GAGs have well-defined structures in a molecular level, and sufficient amounts can be supplied. To study the chemical, biological, medical as well as physical performance of the GAGs, a synthetic approach is strongly recommended. This chapter describes the synthesis of the GAG oligosaccharides focusing on the repeating region.


Hyaluronic Acid Heparan Sulfate Chondroitin Sulfate Dermatan Sulfate Disaccharide Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Jun-ichi Tamura
    • 1
  1. 1.Department of Regional EnvironmentTottori UniversityTottoriJapan

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