Abstract
Accumulating evidence implies that chondroitin sulfate (CS)/dermatan sulfate (DS) has a wide range of biological activities, which result from the ability to interact with various proteins, such as growth factors, cytokines, and neurotrophic factors, thereby causing their activation, inactivation, or stabilization. CS/DS chains are linear polysaccharides composed of the various disaccharide units shown in Fig. 1 (Nandini and Sugahara 2006). Functional domains with distinct sequences, which are recognized by specific protein ligands, are formed by combinations of these disaccharide units. Here, methods for the microsequencing of CS oligosaccharides with specific biological activities are described.
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References
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Sugahara, K., Yamada, S. (2008). Microsequencing of Functional Chondroitin Sulfate Oligosaccharides. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77924-7_18
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DOI: https://doi.org/10.1007/978-4-431-77924-7_18
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77923-0
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