NKT Cells and Their Recognition of Glycolipids

  • Ken-ichiro Seino
  • Masaru Taniguchi


CD1d-restricted Natural Killer T (NKT) cells expressing a single invariant T cell receptor alpha chain recognize glycolipid antigens presented by a CD1d molecule (Taniguchi et al. 2003; Kronenberg 2005)2. Studies have indicated that NKT cells recognize various kinds of glycolipids derived from not only mammals but also from bacteria or marine organisms. NKT cells can produce various biological proteins such as cytokines or cytotoxic molecules upon activation. Through their production, NKT cells influence other immune cells and involve various kinds of immune responses, including autoimmunity, microbe infection, transplant immunity, tumor immunity, and allergic inflammation (Seino and Taniguchi 2004). It is expected to synthesize some glycolipids which could manipulate NKT cell function and the immune system, especially intending to treat some diseases better.


Glycolipid Antigen CD1d Molecule Transplant Immunity Mouse CD1d Sphingosine Chain 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Ken-ichiro Seino
    • 1
  • Masaru Taniguchi
    • 2
  1. 1.Laboratory for Molecular Therapy, Institute of Medical ScienceSt. Marianna UniversityKawasaki, KanagawaJapan
  2. 2.Laboratory for Immune RegulationRIKEN Research Center for Allergy and ImmunologyTsurumi, Yokohama, KanagawaJapan

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