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NKT Cells and Their Recognition of Glycolipids

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Experimental Glycoscience

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Abstract

CD1d-restricted Natural Killer T (NKT) cells expressing a single invariant T cell receptor alpha chain recognize glycolipid antigens presented by a CD1d molecule (Taniguchi et al. 2003; Kronenberg 2005)2. Studies have indicated that NKT cells recognize various kinds of glycolipids derived from not only mammals but also from bacteria or marine organisms. NKT cells can produce various biological proteins such as cytokines or cytotoxic molecules upon activation. Through their production, NKT cells influence other immune cells and involve various kinds of immune responses, including autoimmunity, microbe infection, transplant immunity, tumor immunity, and allergic inflammation (Seino and Taniguchi 2004). It is expected to synthesize some glycolipids which could manipulate NKT cell function and the immune system, especially intending to treat some diseases better.

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References

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Author information

Authors and Affiliations

  1. Laboratory for Molecular Therapy, Institute of Medical Science, St. Marianna University, 2-16 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan

    Ken-ichiro Seino

  2. Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan

    Masaru Taniguchi

Authors
  1. Ken-ichiro Seino
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  2. Masaru Taniguchi
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Editor information

Editors and Affiliations

  1. Department of Disease Glycomics, Research Institute for Microbial Diseases, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) (Professor)

  2. Systems Glycobiology Group, Advanced Science Institute, RIKEN, Wako, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) (Professor)

  3. Institute of Glycotechnology, Future Science and Technology Joint Research Center, Tokai University, Hiratsuka, Kanagawa, 259-1292, Japan

    Akemi Suzuki M.D., Ph.D. (Professor) (Professor)

  4. Synthetic Cellular Chemistry Laboratory, RIKEN Discovery Research Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yukishige Ito Ph.D. (Chief Researcher) (Chief Researcher)

  5. Research Center for Medical Glycoscience, Advanced Industrial Science and Technology, AIST Tsukuba, Central 2, Tsukuba, Ibaraki, 305-8568, Japan

    Hisashi Narimatsu M.D., Ph.D.

  6. Research Center for Glycobiotechnology, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan

    Toshisuke Kawasaki Ph.D. (Professor) (Professor)

  7. Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan

    Sumihiro Hase Ph.D. (Professor) (Professor)

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© 2008 Springer

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Seino, Ki., Taniguchi, M. (2008). NKT Cells and Their Recognition of Glycolipids. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77922-3_34

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