Abstract
In October of 1990, the National Institute for Neurologic Disorders and Stroke (NINDS) launched a randomized, placebo-controlled, blinded, multicenter trial of tissue recombinant plasminogen activator (rt-PA) for acute stroke. Patients must present to a participating hospital quickly enough to receive intravenous rt-PA within 90 or 180 min after stroke onset. The two treatment tiers are balanced through randomization procedures so that equal numbers of patients are treated before 90 min and before 180 min after onset. The two time limits are necessary to extend the promising results of pilot rt-PA stroke studies, which used a 90 min time limit, to a longer enrollment window [1,2]. Patients with ischemic stroke in the carotid or vertebrobasilar territories are eligible, and the study is active in seven cities in the United States (see Appendix for list of investigators and sites).
Supported by N01-NS02377 from the Stroke and Trauma Division, National Institute of Neurologic Disorders and Stroke.
See appendix.
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© 1995 Springer-Verlag Tokyo
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Lyden, P.D., Broderick, J., Mascha, E., The NINDS t-PA Stroke Trial Investigators. (1995). Reliability of the Barthel Index Outcome Measure Selected for the NINDS t-PA Stroke Trial. In: Yamaguchi, T., Mori, E., Minematsu, K., del Zoppo, G.J. (eds) Thrombolytic Therapy in Acute Ischemic Stroke III. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68459-6_39
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DOI: https://doi.org/10.1007/978-4-431-68459-6_39
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