Thrombolytic Therapy in Acute Ischemic Stroke III

1. Front Matter

   Pages II-XV

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2. Basic Understandings in Ischemia-Reperfusion and Neuronal Death

   1. Front Matter

      Pages 1-1

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   2. Time Course of Leukocyte Influx Following Middle Cerebral Artery Occlusion in the Wistar Rat

      • J. H. Garcia, K.-F. Liu, X.-J. Hu

      Pages 3-9

   3. The Role of P-Selectin and ICAM-1 During Focal Brain Ischemia/Reperfusion

      • Y. Okada, G. J. del Zoppo

      Pages 10-18

   4. Delayed Neuronal Death and Ischemic Tolerance

      • T. Kirino, T. Nakagomi, H. Kanemitsu, A. Tamura

      Pages 19-28

   5. Positron Emission Tomography in Patients with an Acute Embolic Occlusion of the Carotid Artery

      • K. Uemura, S. Higano

      Pages 29-36

3. Early Diagnosis and Patient Selection

   1. Front Matter

      Pages 39-39

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   2. Measures for Thombolytic Therapy

      1. Early Findings of Computed Tomography and Angiography in Acute Stroke and Thrombolytic Therapy

         • R. von Kummer

         Pages 41-46

      2. Role of Extracranial Ultrasound and Angioscopy in Thrombolytic Therapy

         • A. Schwartz

         Pages 47-55

      3. Transcranial Contrast-Enhanced Color-Flow Imaging

         • S. M. Otis

         Pages 56-60

      4. Value of Single Photon Emission Computed Tomography in Acute Stroke Therapeutic Trials

         • J. C. Grotta, S. K. Hanson, W. Pasteur, H. Rhoades, H. D. Tran, L. M. Lamki et al.

         Pages 61-71

      5. Correlation of SPECT with Angiography in Early Ischemic Stroke

         • J. Nakagawara, S. Takahashi, M. Senoh, Y. Isayama, R. Takeda, K. Suematsu et al.

         Pages 72-80

      6. New MR Technologies for Diagnosis of Acute Ischemic Stroke: MR Angiography, Diffusion, and Perfusion Imaging

         • S. Warach

         Pages 81-85

4. Early Diagnosis and Patient Selection

   1. Front Matter

      Pages 39-39

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   2. Early Clinical Diagnosis of Acute Ischemic Stroke

      1. Behavioral Syndromes in Early Right Middle Cerebral Artery Territory Stroke

         • A. Yamadori, S. Ohkawa, E. Mori

         Pages 93-98

      2. Symptoms and Signs in Early Vertebrobasilar Territory Stroke

         • L. R. Caplan

         Pages 99-106

      3. Subtypes of Infarction and Their Differentiation: Relevance to Thrombolytic Therapy and Early Randomization

         • I. Henriques, J. Bogousslavsky

         Pages 107-109

5. Strategies for Acute Ischemic Stroke Treatment

   1. Front Matter

      Pages 113-113

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   2. Applications of Diffusion-Weighted Magnetic Resonance Imaging for Stroke Diagnosis and Treatment

      • M. Fisher

      Pages 115-123

   3. Strategies of Early Patient Recruitment: A Community-Based Study

      • O. Busse, B. Müffelmann, J. Glahn, S. Kunz

      Pages 124-129

On the threshold of an exciting new era for acute stroke diagnosis and treatment, the Third International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke was held in Nara, Japan, in April 1994. The symposium brought together some 200 basic and clinical scientists for presentations and discussions of issues vital to the understanding of thrombolytic therapy. This volume compiles the major presentations of the symposium, with attention to applications of new diagnostic measures such as diffusion and perfusion MRI, contrast-enhanced transcranial Doppler and angioscopy. Other presentations examine the mechanisms of ischemia/reperfusion injury, hemorrhagic transformation, and reocclusion, with reviews of recent developments in thrombolytic agents. The proceedings of the symposium will be of special interest to researchers, physicians, and students in the fields of neurology, neurosurgery, and nuclear medicine, as well as those in pharmacology, critical care medicine, and related fields.

• Ischemic Stroke
• acute ischemic stroke
• diffusion and perfusion MRI
• neurology
• neurosurgery
• thrombolytic therapy

• Cerebrovascular Division, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, 565, Japan

  Takenori Yamaguchi, Kazuo Minematsu

• Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Hyogo, 670, Japan

  Etsuro Mori

• Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, La Jolla, USA

  Gregory J. Zoppo

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