Skip to main content

Intravenous Thrombolytic Therapy for Acute Ischemic Stroke

  • Conference paper
Thrombolytic Therapy in Acute Ischemic Stroke III
  • 86 Accesses

Abstract

The logic of thrombolytic therapy includes the two-stage argument that thrombolytic agents recanalize occluded cerebral arteries and early reperfusion is followed by neurological improvement [1]. Intravenous infusion is simple and technically safe, but its efficiency may be low compared with intraarterial infusion because of agent dilution and passive delivery of the drug to the target thrombi through the bloodstream [1,2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mori E (1993) Safety and efficacy of fibrinolytic agents in acute ischemic stroke. Cerebrovasc Dis 3: 264–268

    Article  Google Scholar 

  2. del Zoppo GJ, Pessin MS, Mori E, Hacke W (1991) Thrombolytic intervention in acute thrombotic and embolic stroke. Semin Neurol 11: 368–384

    Article  PubMed  Google Scholar 

  3. Yamaguchi T, Hayakawa T, Kikuchi H, Abe T (1990) Thrombolytic therapy in embolic and thrombotic cerebral infarction: a cooperative study. In: Hacke W, del Zoppo GJ, Hirschberg M (eds) Thrombolytic therapy in acute ischemic stroke. Springer, Berlin Heidelberg New York, pp 161–167

    Google Scholar 

  4. Brott TG, Haley EC Jr, Levy DE, Barsan W, Broderick J, Sheppard GL, Spilker J, Kongable GL, Massey S, Reed R, Marier JR (1992) Urgent therapy for stroke. Part I. Pilot study of tissue plasminogen activator administrated within 90 minutes. Stroke 23: 632–640

    Article  PubMed  CAS  Google Scholar 

  5. Haley EC Jr, Levy DE, Brott TG, Sheppard GL, Wong MCW, Kongable GL, Torner JC, Marier JR (1992) Urgent therapy for stroke. Part II. Pilot study of tissue plasminogen activator administrated 91–180 minutes from onset. Stroke 23: 641–645

    Article  PubMed  Google Scholar 

  6. von Kummer R, Hacke W (1992) Safety and efficacy of intravenous tissue plasminogen activator and heparin in acute middle cerebral artery stroke. Stroke 23: 646–652

    Article  Google Scholar 

  7. del Zoppo. GJ, Poeck K, Pessin MS, Wolpert SM, Furlan AJ, Ferbert A, Alberts MJ, Zivin JA, Wechsler L, Busse O, Greenlee R Jr, Brass L, Mohr JP, Feldmann E, Hacke W, Kase CS, Biller J, Gress D, Otis SM (1992) Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 32: 78–86

    Article  PubMed  Google Scholar 

  8. Overgaard K, Sperling B, Boysen G, Pedersen H, Gam J, Ellemann K, Kane A, ArlienSöborg P, Olsen TS, Videbæk C, Knudsen JB (1993) Thrombolytic therapy in acute ischemic stroke. A Danish pilot study. Stroke 24: 1439–1446

    Article  PubMed  CAS  Google Scholar 

  9. Baird AE, Donnan GA, Austin MC, Fitt GJ, Davis SM, McKay WJ (1994) Reperfusion after thrombolytic therapy in ischemic stroke measured by single-photon emission computed tomography. Stroke 25: 79–85

    Article  PubMed  CAS  Google Scholar 

  10. Mori E, Yoneda Y, Tabuchi M, Yoshida T, Ohkawa S, Ohsumi Y, Kitano K, Tsutsumi A, Yamadori A (1992) Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology 42: 976–982

    PubMed  CAS  Google Scholar 

  11. Yamaguchi T, Hayakawa T, Kikuchi H, Japanese Thrombolysis Study Group (1993) Intravenous tissue plasminogen activator ameliorates the outcome of hyperacute embolic stroke. Cerebrovasc Dis 3: 269–272

    Article  Google Scholar 

  12. Haley EC Jr, Brott TG, Sheppard GL, Barsan W, Broderick J, Marier JR, Kongable GL, Spilker J, Massey S, Hansen CA, Torner JC, TPA Bridging Study Group (1993) Pilot randomized trial of tissue plasminogen activator in acute ischemic stroke. Stroke 24: 1000–1004

    Article  PubMed  Google Scholar 

  13. del Zoppo GJ, Ferbert A, Otis S, Bruckmann H, Hacke W, Zyroff J, Harker LA, Zeumer H (1988) Local intra-arterial fibrinolytic therapy in acute carotid territory stroke. Stroke 19: 307–313

    Article  PubMed  Google Scholar 

  14. Zeumer H, Freitag HJ, Grzyka U, Neeunzig HP (1989) Local intra-arterial fibrinolysis in acute vertebrobasilar occlusion. Technical developments and recent results. Neuroradiology 31: 336–340

    Article  PubMed  CAS  Google Scholar 

  15. Theron J, Courtheoux P, Casasco A, Alachkar F, Notari F, Ganem F, Maiza D (1989) Local intraarterial fibrinolysis in the carotid territory. AJNR 10: 753–765

    PubMed  CAS  Google Scholar 

  16. Zeumer H, Freitag HJ, Zanella F, Thie A, Arning C (1993) Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus recombinant tissue plasminogen activator (rt-PA). Neuroradiology 35: 159–162

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Tokyo

About this paper

Cite this paper

Mori, E. (1995). Intravenous Thrombolytic Therapy for Acute Ischemic Stroke. In: Yamaguchi, T., Mori, E., Minematsu, K., del Zoppo, G.J. (eds) Thrombolytic Therapy in Acute Ischemic Stroke III. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68459-6_33

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68459-6_33

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-70139-2

  • Online ISBN: 978-4-431-68459-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics