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Molecular mechanism of visceral obesity

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Lipoprotein Metabolism and Atherogenesis

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Summary

Visceral fat obesity or visceral fat syndrome coincides with syndrome X or deadly quartet, which is susceptible to atherosclerosis with the clustering of multiple risk factors. Visceral fat is located upstream of the liver via the portal vein. Numerous free fatty acids released from visceral fat are drained into the liver and enhance expression of the genes for lipoprotein synthesis, leading to hyperlipemia. Visceral fat expresses numerous genes for secretory proteins including various bioactive substances. We proposed naming these adipocyte-derived bioactive substances ‘adipocytokines’ One of the examples, plasminogen activator inhibitor-1 gene, is overexpressed in accumulated visceral fat, which may be involved in thrombotic disorders in visceral obesity. A newly found adipose-specific secretory protein, adiponectin, having a collagen-like motif may be related to vascular disorders. Adipocytokines may be a causative factor in the development of atherosclerotic disease in visceral obesity.

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Authors and Affiliations

  1. The Second Department of Internal Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan

    Yuji Matsuzawa, Tohru Funahashi, Tadashi Nakamura, Iichiro Shimomura & Yukio Arita

Authors
  1. Yuji Matsuzawa
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  2. Tohru Funahashi
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  3. Tadashi Nakamura
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  4. Iichiro Shimomura
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  5. Yukio Arita
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Editors and Affiliations

  1. Department of Geriatric Medicine Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Toru Kita M.D. (Professor) & Masayuki Yokode M.D. (Assistant Professor) (Professor) &  (Assistant Professor)

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© 2000 Springer-Verlag Tokyo

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Matsuzawa, Y., Funahashi, T., Nakamura, T., Shimomura, I., Arita, Y. (2000). Molecular mechanism of visceral obesity. In: Kita, T., Yokode, M. (eds) Lipoprotein Metabolism and Atherogenesis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68424-4_4

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  • DOI: https://doi.org/10.1007/978-4-431-68424-4_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68426-8

  • Online ISBN: 978-4-431-68424-4

  • eBook Packages: Springer Book Archive

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