Lipoprotein Metabolism and Atherogenesis

1. Front Matter

   Pages II-XVIII

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2. The Molecular Approach to Risk Factors and Prevention

   1. Front Matter

      Pages 1-1

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   2. Lipoprotein Metabolism and Atherogenesis

      • James Shepherd, Christopher J. Packard

      Pages 3-11

   3. Role Of Lipid Concentrations and Apolipoproteins In Altering ApoB Metabolism and Promoting Coronary Events

      • Frank M. Sacks

      Pages 12-18

   4. Long-term Effect of LDL-Apheresis on Familial Hypercholesterolemia Homozygotes

      • Akira Yamamoto, Akito Kawaguchi, Mariko Harada-Shiba

      Pages 19-25

   5. Molecular mechanism of visceral obesity

      • Yuji Matsuzawa, Tohru Funahashi, Tadashi Nakamura, Iichiro Shimomura, Yukio Arita

      Pages 26-33

   6. Diabetes and Atherosclerosis

      • Shinichi Oikawa, Takashi Naito, Hidetoshi Kotake, Takayoshi Toyota

      Pages 34-36

3. The Molecular Basis of Lipoprotein Metabolism (I)

   1. Front Matter

      Pages 37-37

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   2. Molecular Genetics and Clinical Features of Japanese Patients with Familial Hypercholesterolemia

      • Hiroshi Mabuchi, Atsushi Nohara, Junji Koizumi, Kouji Kajinami

      Pages 39-43

   3. Molecular Analysis of Apolipoprotein A-I and E Mutants in Japan

      • Jun Sasaki

      Pages 44-47

   4. Novel mutations of the LDL Receptor Gene in Familial Hypercholesterolemia Pedigrees in Hokkaido

      • Mitsuru Emi, Tsunenori Hirayama, Masahiro Tsuji, Akira Hata

      Pages 48-50

   5. Preheparin Lipoprotein Lipase Mass Might Reflect the Amount of Working Lipoprotein Lipase in the Whole Body

      • Kohji Shirai, Takeyoshi Murano, Hitoshi Watanabe, Yoh Miyashita, Yoshiaki Itoh, Mitsuya Totsuka

      Pages 51-53

   6. Quantitative Trait Loci (QTLs) for Serum Cholesterol Levels in the Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

      • Takanari Gotoda, Norihiro Kato, Yukio Yamori

      Pages 54-55

   7. Evidence of linkage in familial combined hyperlipidemia to chromosome 1q21-q23

      • Paivi Pajukanta, Christian Ehnholm, Marja-Riitta Taskinen, Leena Peltonen

      Pages 56-58

   8. Molecular Analysis on the LDL Receptors in Two Patients with Homozygous Familial Hypercholesterolemia

      • Yasuko Miyake, Taku Yamamura, Keiko Oi, Hideshi Hori

      Pages 59-61

   9. Common Mutation of 5, 10-Methylenetetrahydrofolate Reductase Accelerates Coronary Artery Disease in Familial Hypercholesterolemia

      • Masa-aki Kawashiri, Kouji Kajinami, Atsushi Nohara, Kunimasa Yagi, Akihiro Inazu, Junji Koizumi et al.

      Pages 62-64

   10. Effect of troglitazone on plasma lipid metabolism and lipoprotein lipase

       • Junji Kobayashi, Izumi Nagashima, Minoru Hikita, Hideaki Bujo, Kazuo Takahashi, Masako Otabe et al.

       Pages 65-67

   11. Combination of LPL gene exon 9 Ser447→Ter nonsense mutation and Apo ε 2 allele might contribute to development of hypertriglyceridemia

       • Takeyoshi Murano, Hitoshi Watanabe, Yoh Miyashita, Yoshiaki Itoh, Mituya Totuka, Kohji Shirai

       Pages 68-70

   12. Improvement by Thiazolidinediones of Vascular Endothelial Cell Dysfunction in Diabetic Patients: A Possible New Physiological Role of PPARγ

       • Daishiro Yamada, Ken Kato, Sanae Midorikawa, Wakano Satoh, Shigeatsu Hashimoto, Hiroaki Satoh et al.

       Pages 71-73

   13. Beneficial Effect of Gemfibrozil on LDL Chemicophysical Characteristics and Oxidizability

       • Hiroshi Yoshida, Makoto Ayaori, Tetsuya Hisada, Toshitsugu Ishikawa, Fumitaka Ohsuzu, Haruo Nakamura

       Pages 74-76

Atherosclerosis leading to coronary heart disease and to cerebrovascular disorders is the number one cause of death in industrialized societies. For the last two decades, great ad­ vances have been made in understanding the pathogenesis of those disorders. Recent studies have revealed that the earliest event in atherogenesis is the adhesion of circulating leukocytes to the vascular endothelial cells and their migration into the subendothelial space. These cells are known to playa central role in the formation of a fatty streak consist­ ing of lipid-laden foam cells. As pathological events continue, the lesion is converted to a more fibrous lesion associated with vascular smooth muscle cells. To solve the enigma of this complicated process, intensive studies in molecular biology have disclosed the genes involved in those events. Some of the genes have been verified by creation of novel animal models, which have led to novel therapeutic strategies for subjects with atherosclerosis. This volume contains papers presented at the International Symposium on Lipoprotein Metabolism and Atherogenesis held in Kyoto December 5-8, 1998, supported in part by the Japan Intractable Diseases Research Foundation. The following three topics were the focus of the three-day program: I) The molecular approach to studying risk factors and prevention 2) The creation of novel animal models 3) Lipoprotein disorder as a cause of activation of vascular endothelial cells Thirty distinguished researchers from the United States, the United Kingdom, Austria, Finland, Australia, and Japan were invited.

• Atherogenesis
• Atherosclerosis
• Insulin
• Lipoprotein Metabolism
• Risk Factors
• Vascular Endothelial Cells
• biology
• cells
• diabetes
• diabetes mellitus
• genes
• metabolism
• prevention
• protein
• receptor tyrosine kinases
• metabolic disease

• Department of Geriatric Medicine Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan

  Toru Kita, Masayuki Yokode

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