Muscular Testing of Malignant Hyperthermia in Europe
Until 1983, malignant hyperthermia (MH) screening was conducted in a limited number of European Centers in a fairly haphazard and ad hoc way. In 1983, the Banff International Workshop on MH ended in confusion as to how best to screen for MH. At that time various blood tests were still being used or suggested, such as creatine kinase (CK), serum pyrophosphate, osmotic red cell fragility, and various white cell tests. The muscle tests included in vitro adenosine triphosphate (ATP) depletion, intracellular Ca2+ release studies, potassium chloride contracture, succinylcholine contracture, and succinylcholine and caffeine contracture. Although all this intense activity was good for learning about the pathoetiology of MH, it was hopeless for diagnostic uniformity. Clearly a disease diagnosed in one center should be diagnosable in the same way as in others, and the testing method should produce the same results.
KeywordsCreatine Kinase Ryanodine Receptor Malignant Hyperthermia Malignant Hyperthermia Malignant Hyperthermia Susceptibility
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