Abstract
Until 1983, malignant hyperthermia (MH) screening was conducted in a limited number of European Centers in a fairly haphazard and ad hoc way. In 1983, the Banff International Workshop on MH ended in confusion as to how best to screen for MH. At that time various blood tests were still being used or suggested, such as creatine kinase (CK), serum pyrophosphate, osmotic red cell fragility, and various white cell tests. The muscle tests included in vitro adenosine triphosphate (ATP) depletion, intracellular Ca2+ release studies, potassium chloride contracture, succinylcholine contracture, and succinylcholine and caffeine contracture. Although all this intense activity was good for learning about the pathoetiology of MH, it was hopeless for diagnostic uniformity. Clearly a disease diagnosed in one center should be diagnosable in the same way as in others, and the testing method should produce the same results.
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References
European Malignant Hyperthermia Group (1984) A protocol for the investigation of malignant hyperthermia (MH) susceptibility. Br J Anaesth 56: 1267–1269
European Malignant Hyperthermia Group (1985) Laboratory diagnosis of malignant hyperthermia susceptibility (MHS). Br J Anaesth 57: 1038
MacLennan DH, Duff C, Zorato F, Fujii J, Philips MS, Korneluk RG, Frondis W, Britt BA, Worton RG (1990) Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia. Nature 343: 559–561
McCarthy TV, Healy JMS, Heffron JJA, Lehane M, Deufel T, Lehmann-Horn F, Farral M, Johnson K (1990) Localisation of the malignant hyperthermia susceptibility locus to human chromosome 19q 12–13.2. Nature 343: 562–564
Healy SJM, Heffron JJA, Lehane M, Bradley DG, Johnson K, McCarthy TV (1991) Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers. BMJ (London) 303: 1225–1228
Levitt RG, Nouri J, Jedika AE, McKusick VA, Marks A, Shutak JG, Fletcher JE, Rosenberg H, Meyers DA (1991) Evidence for the localisation of a malignant hyperthermia susceptible locus (MHS 2) to human chromosome 17q. Genomics 11: 543–547
Deufel T, Heitinger T, Golla A, Johnson K, MacLennan DH, Lehmann-Horn F (1991) Two recombinations between malignant hyperthermia susceptibility and human ryanodine receptor in a single family: another gene for MHS? Human Gene Mapping 11: Cytogenet Cell Gene 58: 2018–2019
Deufel T, Golla A, Iles DE, Meindl A, Meitinger T, Schindelhauer D, DeVries A, Pongratz D, MacLellan DH, Hohnson KJ, Lehmann-Horn F (1992) Evidence for genetic heterogeneity of malignant hyperthermia susceptibility. Am J Hum Genet 50: 1151–1161
Sudbrak R, Procaccio V, Klausnitzer M, Curran JL, Monsieurs K, Van Broeckhoven C, Ellis FR, Heytens L, Hartung EJ, Kozak-Ribbens G, Heilinger D, Weissenback J, Lehmann-Horn F, Mueller CR, Deufel T, Stewart AD, Lunardi J (1995) Mapping of a further malignant hyperthermia susceptibility (MHS) locus to chromosome 3g13.1. Am J Hum Genet 56: 684–691
Ball SP, Dorkings HR, Ellis FR, Halsall PJ, Hopkins PM, Mueller RF, Stewart AD (1993) Genetic linkage analysis of chromosome 19 markers in malignant hyperthermia. Br J Anaesth 70: 70–75
Stewart AD (1993) DNA studies in some Leeds malignant hyperthermia families. Presented at the December Meeting of the Genetics Section of the European Malignant Hyperthermia Group, London 1993
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© 1996 Springer-Verlag Tokyo
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Ellis, F.R. (1996). Muscular Testing of Malignant Hyperthermia in Europe. In: Morio, M., Kikuchi, H., Yuge, O. (eds) Malignant Hyperthermia. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68346-9_9
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DOI: https://doi.org/10.1007/978-4-431-68346-9_9
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