Malignant Hyperthermia

1. Front Matter

   Pages II-XV

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2. History of Malignant Hyperthermia

   1. Front Matter

      Pages 1-1

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   2. History of Malignant Hyperthermia

      • Beverley A. Britt

      Pages 3-17

3. Clinical Classification and Incidence of Fulminant and Abortive Malignant Hyperthermia

   1. Front Matter

      Pages 19-19

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   2. The Incidence of Malignant Hyperthermia in Denmark

      • Helle Ørding, Diana Bendixen

      Pages 21-24

   3. Malignant Hyperthermia in Austria 1984–1993

      • Dorrit Heilinger, Eva Donner, Andrea Sauberer, Werner Hackl, Walter Mauritz

      Pages 25-32

   4. Clinical Classification and Incidence of Fulminant and Abortive Malignant Hyperthermia Reactions in Italy

      • V. Tegazzin, A. Accorsi, I. Moroni, D. Di Martino, V. Brancadoro, V. Peduto

      Pages 33-37

   5. The Epidemiology of Malignant Hyperthermia Events in North America

      • Marilyn Green Larach, Linda J. Fuhrmann, Gregory C. Allen

      Pages 39-41

   6. Clinical Classification and Incidence of Malignant Hyperthermia in Australia

      • Michael A. Denborough

      Pages 43-47

   7. Clinical Classification and Incidence of Malignant Hyperthermia in Japan

      • Osafumi Yuge, Michio Morio, Hirosato Kikuchi, Keiko Mukaida, Yasuhiro Maehara, Masakazu Nakao et al.

      Pages 49-56

4. Muscular Testing of Malignant Hyperthermia

   1. Front Matter

      Pages 57-57

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   2. Testing for Malignant Hyperthermia in North America and Australia

      • Henry Rosenberg

      Pages 59-62

   3. Muscular Testing of Malignant Hyperthermia in Europe

      • F. R. Ellis

      Pages 63-66

   4. Caffeine Contracture of the Skinned Muscle Fiber in Malignant Hyperthermia and Neuromuscular Diseases

      • Akio Takagi, Makoto Araki, Susumu Kojima, Masayoshi Ida, Tomoji Watanabe

      Pages 67-73

   5. Calcium-Induced Calcium Release Test

      • Makoto Endo

      Pages 75-75

5. Genetic Study of Malignant Hyperthermia

   1. Front Matter

      Pages 77-77

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   2. Mutations in the Skeletal Muscle Ryanodine Receptor (RYR1) Gene are Linked to Malignant Hyperthermia and Central-Core Disease

      • David H. MacLennan

      Pages 79-86

   3. Chromosome 17 Candidate Gene Analysis in a Population Referred Because of Suspected Susceptibility to Malignant Hyperthermia

      • Gary M. Vita, Antonel Olckers, Anne E. Jedlicka, Terry Heiman-Patterson, Alfred L. George, Jeffery E. Fletcher et al.

      Pages 87-93

   4. Disease Expression and Gene Expression Can Be Quite Distinct: Modulation of Skeletal Muscle Sodium Channels by the Human Myotonin Dystrophy Protein Kinase (HMPK)

      • J. Paul Mounsey, Puting Xu, J. Edward John III, John Gilbert, Allen D. Roses, J. Randall Moorman

      Pages 95-101

6. Biological Study of Malignant Hyperthermia

   1. Front Matter

      Pages 103-103

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In susceptible individuals, malignant hyperthermia (MH) can be triggered by various anesthetics during surgery. First described in 1960, research since then has concentrated on reducing the very high mortality rate associated with MH. Although significant progress in treatment has been made with the introduction of dantrolene sodium in 1979, many questions remain unanswered. Following on the results of more than 30 years of investigative efforts, the Third International Symposium on MH was held in Hiroshima, Japan, in 1994, immediately before the Seventh International Workshop on MH. Specialists in the field discussed the most up-to-date findings from the point of view of clinical classification, history, and incidence based on the evidence of epidemiology, diagnostic muscle testing, genetics, and biochemistry. These proceedings of the symposium present important keys to understanding the mechanism of MH and related syndromes at the genetic level and include procedures for the monitoring and care of patients. This volume will be invaluable not only for surgeons and anesthesiologists but also for physiologists and researchers.

• Etiology
• Malignant Hyperthermia
• Treatment
• biochemistry
• care
• classification
• genetics
• monitoring
• mortality
• muscle
• pain
• patients
• research
• surgery
• syndromes

• Chugoku Rosai General Hospital, Hiroshima University, Kure, Hiroshima, Japan

  Michio Morio

• The First Department of Anesthesiology, Toho University School of Medicine, Ohta-ku, Tokyo, 143, Japan

  Hirosato Kikuchi

• Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, 734, Japan

  Osafumi Yuge

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