Mitochondrial Disorders in Malignant Hyperthermia

  • Geneviève Kozak-Ribbens
Conference paper


Some muscle disorders are known to be associated with malignant hyperthermia (MH), including King-Denborough syndrome and central-core disease (CCD), and occasionally Duchenne muscular dystrophy and myotonias. Among them, mitochondrial myopathies (MM) have been occasionally reported [1,2]. In a recent publication by Harriman concerning 1400 patients investigated by the Leeds MH unit (R. Ellis), no histological sign of MM such as ragged red fibers or negative staining of cytochrome c oxidase was described [3]. Our results are in agreement with those of Harriman: whatever the in vitro contracture test results, pathological findings were heterogenous [4]. Therefore, our observation of mitochondrial abnormalities in 25 of 234 patients (10.6%) led us to investigate these patients further by additional adequate tests.


Malignant Hyperthermia Malignant Hyperthermia Carnitine Palmitoyl Transferase Mitochondrial Myopathy Mitochondrial Defect 
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Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • Geneviève Kozak-Ribbens
    • 1
  1. 1.Laboratoire Associé à l’Assistance Publique à Marseille, Faculté de MédecineCentre de Résonance Magnétique et Médicale (CRMBM), Centre National de la Recherche Scientifique (CNRS) Unité de Recherche Associée (URA) 1186MarseilleFrance

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