Mitochondrial Disorders in Malignant Hyperthermia
Some muscle disorders are known to be associated with malignant hyperthermia (MH), including King-Denborough syndrome and central-core disease (CCD), and occasionally Duchenne muscular dystrophy and myotonias. Among them, mitochondrial myopathies (MM) have been occasionally reported [1,2]. In a recent publication by Harriman concerning 1400 patients investigated by the Leeds MH unit (R. Ellis), no histological sign of MM such as ragged red fibers or negative staining of cytochrome c oxidase was described . Our results are in agreement with those of Harriman: whatever the in vitro contracture test results, pathological findings were heterogenous . Therefore, our observation of mitochondrial abnormalities in 25 of 234 patients (10.6%) led us to investigate these patients further by additional adequate tests.
KeywordsMalignant Hyperthermia Malignant Hyperthermia Carnitine Palmitoyl Transferase Mitochondrial Myopathy Mitochondrial Defect
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