Abstract
Fifty-eight patients with familial adenomatous polyposis participated in a four-year, randomized, double-blind, placebo-controlled chemoprevention trial. Twenty patients were treated with ascorbic acid (vitamin C) 4 g/day, plus alpha tocopherol (vitamin E) 400 mg/day, plus a high-fiber supplement (22.5 g/day). Sixteen patients were treated with the vitamins and a low-fiber supplement (2.2 g/day). Twenty-two were treated with placebo capsules and the low-fiber supplement. The endpoint of the study was change in number and area of rectal polyps. Analysis by patient compliance showed a significant benefit for patients who ingested more than 11 g/day of the wheat fiber supplement.
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De Cosse, J.J., Jacobson, J.S. (1990). Chemoprevention Using Wheat Fiber and Vitamins C and E in Patients with Familial Adenomatous Polyposis. In: Utsunomiya, J., Lynch, H.T. (eds) Hereditary Colorectal Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68337-7_43
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DOI: https://doi.org/10.1007/978-4-431-68337-7_43
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