Hereditary Colorectal Cancer

1. Front Matter

   Pages I-XXIV

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2. General Aspects of Hereditary Colorectal Cancer

   1. Front Matter

      Pages 1-1

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   2. The Concept of Hereditary Colorectal Cancer and the Implications of Its Study

      • Joji Utsunomiya

      Pages 3-16

   3. Historical and Natural Cancer History Facets of the Lynch Syndromes

      • Henry T. Lynch, Stephen J. Lanspa, Thomas C. Smyrk, Robert J. Fitzgibbons Jr., Patrice Watson, Bruce M. Boman et al.

      Pages 17-25

   4. Eldon Gardner Memorial Lecture: Genetic Mapping and Allelic Heterogeneity of the Familial Polyposis Gene

      • Mark Leppert, Yusuke Nakamura, Randall Burt, J. P. Hughes, Wade Samowitz, Scott Woodward et al.

      Pages 27-36

   5. Hereditary Colorectal Cancer: A Commentary

      • Walter F. Bodmer

      Pages 37-42

3. Identification, Surveillance, and Management of Polyposis Syndrome

   1. Front Matter

      Pages 43-43

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   2. Summary of Chapter 2: Identification, Surveillance and Management of Polyposis Syndrome

      • Steffen Bülow

      Pages 45-49

   3. Familial Adenomatous Polyposis Study: The Report of the Leeds Castle Polyposis Meeting

      • Jerome J. DeCosse

      Pages 51-54

   4. Surveillance of Danish Families with Adenomatous Polyposis: Results of the Danish Polyposis Register

      • Steffen Bülow

      Pages 55-56

   5. Value of Registration in the Identification and Surveillance of Familial Adenomatous Polyposis in the Netherlands

      • G. Griffioen, H. F. A. Vasen, F. C. A. den Hartog Jager, F. M. Nagengast, H. W. Verspaget, P. Meera Khan et al.

      Pages 57-62

   6. Current Status of the Registration of Familial Adenomatous Polyposis at the Polyposis Center in Japan

      • Takeo Iwama, Yoshio Mishima, Joji Utsunomiya

      Pages 63-69

   7. Management of Familial Polyposis in Poland

      • Piotr Krokowicz

      Pages 71-74

   8. The Probability of Developing Familial Adenomatous Polyposis: Combining the Diminishing Risks with Age with Negative Screening at Advancing Age and Linked Gene Markers

      • Joan Slack

      Pages 75-80

   9. Follow-up Study of Associated Tumors in Cases of Familial Adenomatous Polyposis

      • Kyosuke Ushio

      Pages 81-89

   10. Retinal Pigmentations in Familial Adenomatous Polyposis, and Linkage Study on Gene Probes on Chromosome 5q

       • Shozo Baba, Masato Tsuchiya, Hiroyuki Machida, Masao Yamada

       Pages 91-96

   11. Congenital Hypertrophy of the Retinal Pigment Epithelium: A Clinical Marker for Familial Adenomatous Polyposis

       • A. Romania, F. Heyen, D. Jagelman, J. Church, Z. Zakov, I. Lavery et al.

       Pages 97-99

4. Identification, Surveillance, and Management of Hereditary Nonpolyposis Colorectal Cancer

   1. Front Matter

      Pages 101-101

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   2. Summary of Chapter 3: Identification, Surveillance and Management of Hereditary Non-polyposis Colorectal Cancer

      • Randall W. Burt

      Pages 103-105

   3. Hereditary Nonpolyposis Colorectal Cancer and Tumorigenesis in the Human Body

      • Kyosuke Ushio

      Pages 107-113

Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen­ tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino­ genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri­ zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ­ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.

• biomolecular genetics classification
• colorectal cancer genetics
• markers
• registries
• screening
• cancer
• classification
• colorectal cancer
• DNA
• gastrointestinal tract
• genetics
• molecular genetics
• mutagen
• oncology
• oncovirus
• pathology
• tumor
• hepatology

• Second Department of Surgery, Hyogo College of Medicine, Hyogo, 663, Japan

  Joji Utsunomiya

• Department of Preventive Medicine, Creighton University School of Medicine, Hereditary Cancer Center, Omaha, USA

  Henry T. Lynch

Policies and ethics