Skip to main content
SpringerLink
Log in

Inhibitory Effect of Eicosapentaenoic Acid on Colon Carcinogenesis

  • Conference paper
Hereditary Colorectal Cancer

  • 60 Accesses

Abstract

The effect of purified eicosapentaenoic acid (EPA, n-3 polyunsaturated fatty acid) on azoxymethane(AOM)-induced colon carcinogenesis, the alteration of fatty acid composition, and prostaglandin E2 in colon tumors and normal colon mucosa were studied, in comparison to linoleic acid(n-6 polyunsaturated fatty acid). The tumor incidence and tumor multiplicity(tumors per rat) in the colon were significantly lower in rats on an EPA diet than in those on a linoleic acid diet. The results suggest that EPA has an inhibitory effect on colon carcinogenesis by modulating prostaglandin synthesis and bile acid metabolism.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Balasubramaniam S, Simons LA, Chang S, Hickie JB (1985) Reduction in plasma cholesterol and increase in biliary cholesterol by a diet rich in n-3 fatty acids in rats. J. Lipid Res. 26: 684–689

    PubMed  CAS  Google Scholar 

  • Bang HO, Dyerberg J (1972) Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Med.Scand. 192: 85–94

    Article  PubMed  CAS  Google Scholar 

  • Bang HO, Dyerberg J, Njørne N (1976) The composition of food consumed by Greenland Eskimos. Acta Med.Scand. 200: 69–73

    Article  PubMed  CAS  Google Scholar 

  • Bennett A, Tacca MD, Stamford IF, Zebro T (1977) Prostaglandins from tumors of human large bowel. Br. J. Cancer 35: 881–884

    Article  PubMed  CAS  Google Scholar 

  • Brenner RR, Peluffo RO (1967) Inhibitory effect of docosa-4, 7, 10, 13, 16, 19-hexaenoic acid upon the oxidative desaturation of linoleic into γ-linoleic acid and α-linoleic acid into octadeca-6, 9, 12, 15-tetraenoic acid. Biochim.Biophys.Acta 137: 184–186

    Article  PubMed  CAS  Google Scholar 

  • Brenner RR (1984) Effect of unsaturated acids on membrane structure and enzyme kinetics. Proc.Lipid Res. 23: 69–96

    Article  CAS  Google Scholar 

  • Bull AW, Soullier BK, Wilson PS, Hayden MT, Nigro ND (1981) Promotion of azoxymethane-induced intestinal cancer by high fat diet in rats. Cancer Res. 41: 3700–3705

    Google Scholar 

  • Carroll KK, Braden LM, Bell JA, Kalamegham R (1986) Fat and cancer. Cancer(Phila) 58: 1818–1825

    Article  CAS  Google Scholar 

  • Culp BR, Titus BG, Land WEM (1979) Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid. Prostaglandins Med. 3: 269–278

    Article  PubMed  CAS  Google Scholar 

  • Dyerberg J, Bang HO, Njørne N (1975) Fatty acid composition of the plasma lipids in Greenland Eskimos. Am.J.Clin.Nutr. 28: 958–966

    PubMed  CAS  Google Scholar 

  • Dyerberg J, Bang HO, Stoffersen E, Moncada S, Uane JR (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 2: 117–119

    Article  PubMed  CAS  Google Scholar 

  • Hill MJ, Drasar BS, Williams REO, Maeda TW, Cox AG, Simpson JEP, Morson BC (1975) Faecal bile-acids and clostridia in patients with cancer of the large bowel. Lancet 1: 535–539

    Article  PubMed  CAS  Google Scholar 

  • Hiramatsu Y, Takada H, Yamamura M, Hioki K, Saito K, Yamamoto M (1983) Effect of dietary cholesterol on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 4: 553–558

    Article  PubMed  CAS  Google Scholar 

  • Jain M, Cook GM, Davis FG, Grace MG, Home GP, Miller AB (1980) A case-control study of diet and colo-rectal cancer. Int.J.Cancer 26: 757–768

    Article  PubMed  CAS  Google Scholar 

  • Lanier AP, Bender TR, Blot WJ, Fraumeri Jr JF, Hurlburt WB (1976) Cancer incidence in Alaska natives. Int.J.Cancer 18: 409–412

    Article  PubMed  CAS  Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J.Biol.Chem. 193: 265–275

    PubMed  CAS  Google Scholar 

  • Meydani SN, Stocking LM, Shapiro AC, Meydani M, Blumberg JB (1988) Fish oil and tocopherol induced changes in ex vivo synthesis of spleen and lung leukotrien B4. Ann.N.Y.Acad.Sci. 524: 395–398

    Article  Google Scholar 

  • Minoura T, Takata T, Sakaguchi M, Takada H, Yamamura M, Hioki K, Yamamoto M (1988) Effect of dietary eicosapentaenoic acid on azoxymethane-induced colon carcinogenesis in rats. Cancer Res. 48: 4790–4794

    PubMed  CAS  Google Scholar 

  • Narisawa T, Magadia NE, Weisburger JH, Wynder EL (1974) Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N′-nitro-N-nitrosoguanidine in rats. J.Natl.Cancer Inst. 53: 1093–1097

    PubMed  CAS  Google Scholar 

  • Narisawa T, Sato M, Tani M, Kudo T, Takahashi T, Goto A (1981) Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment. Cancer Res. 41:1954–1957

    PubMed  CAS  Google Scholar 

  • Narisawa T, Takahashi M, Niwa M, Fukaura Y, Wakizaka A (1987) Involvement of prostaglandin E2 in bile acid-caused promotion of colon carcinogenesis and antipromotion by the cyclooxygenase inhibitor indomethacin. Jpn.J.Cancer Res.(Gann) 78: 791–798

    CAS  Google Scholar 

  • Nielsen NH, Hansen JPH (1980) Breast cancer in Greenland-selected epidemic-logical, clinical and histological features. J. Cancer Res.Clin.Oncol. 98: 287–299

    Article  PubMed  CAS  Google Scholar 

  • Owen RW, Tompson MH, Hill MJ, Wilpart M, Mainguet P, Roberfroid M (1987) The importance of ratio of lithocholic to deoxycholic acid in large bowel carcinogenesis. Nutr. and Cancer 9: 67–71

    Article  CAS  Google Scholar 

  • Owen RW, Dodo M, Thompson MH, Hill MJ (1987) Fecal steroids and colorectal cancer. Nutr. and Cancer 9: 73–80

    Article  CAS  Google Scholar 

  • Pegg AE, McCann PP (1982) Polyamine metabolism and function. Am.J.Physiol. 243: 212–221

    Google Scholar 

  • Reddy BS, Cohen LA, McCoy GD, Hill P, Weisburger JH, Wynder EL (1980) Nutrition and its relationship to cancer. Adv.Cancer Res. 32: 237–345

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS, Maeura Y (1984) Tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female F344 rats: influence of amount and sources of dietary fat. J.Natl.Cancer Inst. 72: 745–750

    PubMed  CAS  Google Scholar 

  • Reddy BS, Tanaka T, Simi B (1985) Effect of different levels of dietary trans fat or corn oil on azoxymethane-induced colon carcinogenesis in F344 rats. J.Natl.Cancer Inst. 75: 791–798

    PubMed  CAS  Google Scholar 

  • Reddy BS, Maruyama H (1986) Effect of dietary fish oil on azoxymethane-induced colon carcinogenesis in male F344 rats. Cancer Res. 46: 3367–3370

    PubMed  CAS  Google Scholar 

  • Reddy BS, Sugie S (1988) Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res. 48: 6642–6647

    PubMed  CAS  Google Scholar 

  • Sakaguchi M, Hiramatsu Y, Takada H, Yamamura M, Hioki K, Saito K, Yamamoto M (1984) Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. Cancer Res. 44:1472–1477

    PubMed  CAS  Google Scholar 

  • Sakaguchi M, Minoura T, Hiramatsu Y, Takada H, Yamamura M, Hioki K, Yamamoto M (1986) Effect of dietary saturated and unsaturated fatty acids on fecal bile acids and colon carcinogenesis induced by azoxymethane in rats. Cancer Res. 46: 61–65

    PubMed  CAS  Google Scholar 

  • Slaga TJ (1983) Overview of tumor promotion in animals. Environ.Health Perspect. 50: 3–14

    Article  PubMed  CAS  Google Scholar 

  • Takada H, Hirooka T, Hiramatsu Y, Yamamoto M (1982) Effect of 3-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats. Cancer Res. 42: 331–334

    PubMed  CAS  Google Scholar 

  • Wargovich MJ, Felkner IC (1985) Metabolic activation of DMH by colonic microsomes: a process influenced by types of dietary fat. Nutr.Cancer 4:146–153

    Article  Google Scholar 

  • Wynder EL (1975) The epidemiology of large bowel cancer. Cancer Res. 35: 3388–3394

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Hideho Takada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshiyuki Minoura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Toshiyuki Takata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michitomo Sakaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kazuhiko Yoshioka
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manabu Yamamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Koshiro Hioki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masakatsu Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Second Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663, Japan

    Joji Utsunomiya M. D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Preventive Medicine, Creighton University School of Medicine, Hereditary Cancer Center, California at 24th Street, Omaha, NE, 68178, USA

    Henry T. Lynch M. D. (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Japan

About this paper

Cite this paper

Takada, H. et al. (1990). Inhibitory Effect of Eicosapentaenoic Acid on Colon Carcinogenesis. In: Utsunomiya, J., Lynch, H.T. (eds) Hereditary Colorectal Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68337-7_37

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68337-7_37

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68339-1

  • Online ISBN: 978-4-431-68337-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation