Molecular Biology

  • Parviz M. Pour
  • Yoichi Konishi
  • Günter Klöppel
  • Daniel S. Longnecker


Morphological studies of pancreatic cancers do not provide sufficient information to predict their biological behavior. The study of genetic abnormalities in pancreatic cancers may open new paths for understanding the etiology and pathogenesis of the disease, and may help in establishing markers for diagnosis and prognosis. There is increasing evidence that it is the accumulation of different genetic abnormalities, rather than a single gene defect, that underlies the multistage processes of tumorigenesis and progression of malignancy [1]. Growth factors and their receptors, tumor suppressor genes, and oncogenes have received considerable attention and seem to be promising in assessing of malignant potential [2].


Pancreatic Cancer Chronic Pancreatitis Human Pancreatic Cancer Biliary Tract Cancer Transform Growth Factor Alpha 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Parviz M. Pour
    • 1
  • Yoichi Konishi
    • 2
  • Günter Klöppel
    • 3
  • Daniel S. Longnecker
    • 4
  1. 1.The Eppley Institute for Research in Cancer; Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of Oncological Pathology, Cancer CenterNara Medical CollegeKashihara, NaraJapan
  3. 3.Department of Pathology, Academy Hospital JetteFree University of BrusselsBrusselsBelgium
  4. 4.Department of PathologyDartmouth Medical SchoolHanoverUSA

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