Morphological studies of pancreatic cancers do not provide sufficient information to predict their biological behavior. The study of genetic abnormalities in pancreatic cancers may open new paths for understanding the etiology and pathogenesis of the disease, and may help in establishing markers for diagnosis and prognosis. There is increasing evidence that it is the accumulation of different genetic abnormalities, rather than a single gene defect, that underlies the multistage processes of tumorigenesis and progression of malignancy . Growth factors and their receptors, tumor suppressor genes, and oncogenes have received considerable attention and seem to be promising in assessing of malignant potential .
KeywordsPancreatic Cancer Chronic Pancreatitis Human Pancreatic Cancer Biliary Tract Cancer Transform Growth Factor Alpha
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