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Preneoplastic Lesions of the Exocrine Pancreas

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Atlas of Exocrine Pancreatic Tumors

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Abstract

Recognition and ablation of preneoplastic or in situ stage neoplasms is an ideal method for prevention of cancers. This approach is particularly difficult for internal organs such as the pancreas that are not conveniently visualized or accessible for physical examination, biopsy or evaluation by cytologic studies. Thus, there is relatively little prospective experience in the recognition of preneoplastic lesions of the human pancreas. Several retrospective approaches have been utilized in attempts to recognize such lesions.

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References

  1. Cubilla AL, Fitzgerald PJ (1976) Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res 36: 2690–2698

    PubMed  CAS  Google Scholar 

  2. Klöppel G, Bommer G, Rückert K, Seifert G (1980) Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis. Virchows Arch [A] 387: 221–233

    Article  Google Scholar 

  3. Kozuka S, Sassa R, Taki T, Masamoto K, Nagasawa S, Saga S, Hasegawa B, Takeuchi M (1979) Relation of pancreatic duct hyperplasia to carcinoma. Cancer 43: 1418–1428

    Article  PubMed  CAS  Google Scholar 

  4. Longnecker DS, Hashida Y, Shinozuka H (1980) Relationship of age to prevalence of focal acinar cell dysplasia in the human pancreas. J Natl Cancer Inst 65: 63–66

    PubMed  CAS  Google Scholar 

  5. Konishi Y, Mizumoto K, Kitazawa S, Tsujiuchi T, Tsutsumi M, Kamano T (1990) Early ductal lesions of pancreatic carcinogenesis in animals and humans. Int J Pancreatol 7: 83–89

    PubMed  CAS  Google Scholar 

  6. Longnecker DS (1986) Experimental models of exocrine pancreatic tumors. In: Go VLM, Brooks FP, DiMango EP et al. (eds) The Exocrine pancreas: Biology, pathobiology and diseases. Raven, New York, pp 443–458

    Google Scholar 

  7. Pour P, Althoff J, Takahashi M (1977) Early lesions of pancreatic ductal carcinoma in the hamster model. Am J Pathol 88: 291–308

    PubMed  CAS  Google Scholar 

  8. Shibata D, Capella G, Perucho M (1990) Mutational activation of the c-K-ras gene in human pancreatic carcinoma. Baillieres Clin Gastroenterol 4: 151–169

    Article  PubMed  CAS  Google Scholar 

  9. Chan P, Teoh TB (1967) The pathology of Clonorchis sinensis infestation of the pancreas. J Pathol 93: 185–189

    Article  CAS  Google Scholar 

  10. Oertel JE (1989) The Pancreas. Non-neoplastic alterations. Am J Surg Pathol 13: 50–65

    Article  PubMed  Google Scholar 

  11. Pour PM, Sayed S, Sayed G (1982) Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases. Am J Clin Pathol 77: 137–152

    PubMed  CAS  Google Scholar 

  12. Sessa F, Bonato M, Frigerio B, Capella C, Solcia E, Prat M, Bara J, Samloff IM (1990) Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells. Gastroenterology 98: 1655–1665

    PubMed  CAS  Google Scholar 

  13. Sommers SC, Murphy SA, Warren S (1954) Pan-creatic duct hyperplasia and cancer. Gastro¬enterology 27: 629–640

    CAS  Google Scholar 

  14. MacCarty RL, Stephens DH, Brown AL, Carlson HC (1975) Retrograde pancreatography in autopsy specimens. Mayo Clinic Proc 123: 359–366

    CAS  Google Scholar 

  15. Schmitz-Moormann P, HeinJ (1976) Altersveränderrungen des Pankreasgangsystems und ihre Rück wirkungen auf das Parenchym. Virchows Arch [A] 371: 145–152

    CAS  Google Scholar 

  16. Klöppel G (1984) Pancreatic non-endocrine tumours. In: Klöppel G, Heitz PU (eds) Pancreatic 31. Pathology. Churchill Livingstone, Edinburgh, pp 79–113

    Google Scholar 

  17. Cubilla AL, Fitzgerald PJ (1984) Tumors of the exocrine pancreas. In: Hartmann WH (ed) Atlas of tumor pathology, 2nd series, fasicle 19. Washington DC, Armed Forces Institute of Pathology, p 83

    Google Scholar 

  18. Bockman DE (1981) Cells of origin of pancreatic cancer: Experimental animal tumors related to human pancreas. Cancer 47: 1528–1534

    Article  PubMed  CAS  Google Scholar 

  19. Stamm BH (1984) Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: A systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol 15: 677–683

    Article  PubMed  CAS  Google Scholar 

  20. Parsa I, Longnecker DS, Scarpelli DG, Pour P, Reddy JK, Lefkowitz M (1985) Ductal metaplasia of human exocrine pancreas and its association with carcinoma. Cancer Res 45: 1285–1290

    PubMed  CAS  Google Scholar 

  21. Glenner G, Mallory GK (1956) The cystadenoma and related nonfunctional tumors of the pancreas. Pathogenesis, classification, and significance. Cancer 9: 980–996

    Article  PubMed  CAS  Google Scholar 

  22. Longnecker DS, Shinozuka H, Dekker A (1980) Focal acinar cell dysplasia in human pancreas. Cancer 45: 534–540

    Article  PubMed  CAS  Google Scholar 

  23. Kishi K, Nakamura K, Yoshimori M, Tajiri H, Ozaki H, Kinoshita T, Kosuge T, Hayakawa M (1992) Morphology and pathological signficance of focal acinar cell dysplasia of the human pancreas. Pancreas 7: 177–182

    Article  PubMed  CAS  Google Scholar 

  24. Mizumoto K, Tsutsumi M, Kitazawa S, Tsujita S, Nakayama M, Tsujii T, Kanehiro H, Nakajima Y, Nakano H, Konishi Y (1990) Intraductal carcinoma in a surgically resected pancreas with chronic pancreatitis. Int J Pancreatol 7: 279–285

    Google Scholar 

  25. Chen J, Baithun SI, Ramsay MA (1985) Histogenesis of pancreatic carcinoma: A study based on 248 cases. J Pathol 146: 65–76

    Article  PubMed  CAS  Google Scholar 

  26. Mizumoto K, Inagaki T, Koizumi M, Uemura M, Ogawa M, Kitazawa S, Tsutsumi M, Toyokawa M, Konishi Y (1988) Early pancreatic duct adenocarcinoma. Hum Pathol 19: 242–244

    Article  PubMed  CAS  Google Scholar 

  27. Mukada T, Yamada S (1982) Dysplasia and carcinoma in situ of the exocrine pancreas. Tohoku J Exp Med 137: 115–124

    Article  PubMed  CAS  Google Scholar 

  28. Liou T-C, Lin X-Z, Chang T-t, Lin C-y, Lin P-W, Jin Y-T, Yu C-Y (1992) Pancreas divisum with early pancreatic cancer-presenting as chronic obstructive pancreatitis. Pancreas 2: 251–256.

    Article  Google Scholar 

  29. Ferrari BT, O’Halloran RL, Longmire WP, Lewin KJ (1979) Atypical papillary hyperplasia of the pancreatic duct mimicking obstructing pancreatic carcinoma. N Engl J Med 301: 531–532

    Article  PubMed  CAS  Google Scholar 

  30. Morohoshi T, Kanda M, Asanuma K, Klöppel G (1989) Intraductal papillary neoplasms of the pancreas. A clinicopathologic study of six patients. Cancer 64: 1329–1335

    Article  PubMed  CAS  Google Scholar 

  31. Yanagisawa A, Kato Y, Ohtake K, Kitagawa T, Ohashi K, Hori M, Takagi K, Sugano H (1991) c- Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res 82: 1057–1060

    Article  PubMed  CAS  Google Scholar 

  32. Lemoine NR, Jain J, Hughes C, Staddon SL, Maillet B, Hall PA, Klöppel G (1992) Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 102: 230–236

    PubMed  CAS  Google Scholar 

  33. Volkholz H, Stolte M, Becker V (1982) Epithelial dysplasias in chronic pancreatitis. Virchows Arch [A] 396: 331–349

    Article  CAS  Google Scholar 

  34. Shinozuka H, Lee RE, Dunn JL, Longnecker DS (1980) Multiple atypical acinar cell nodules of the pancreas. Hum Pathol 11: 389–391

    Article  PubMed  CAS  Google Scholar 

  35. Klöppel G (1989) Cancer of the pancreas: Morphological and biological aspects. In: Preece P, Cushieri A, Rosin RD (eds) Cancer of the bile ducts and pancreas. WB Saunders, Philadelphia, pp 113–138

    Google Scholar 

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Author information

Authors and Affiliations

  1. The Eppley Institute for Research in Cancer; Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198-6805, Omaha, NE, USA

    Parviz M. Pour M.D.

  2. Department of Oncological Pathology, Cancer Center, Nara Medical College, Kashihara, Nara, 634, Japan

    Yoichi Konishi M.D.

  3. Department of Pathology, Academy Hospital Jette, Free University of Brussels, 1090, Brussels, Belgium

    Günter Klöppel M.D.

  4. Department of Pathology, Dartmouth Medical School, 03756, Hanover, NH, USA

    Daniel S. Longnecker M.D.

Authors
  1. Parviz M. Pour M.D.
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  2. Yoichi Konishi M.D.
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  3. Günter Klöppel M.D.
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  4. Daniel S. Longnecker M.D.
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Editor information

Editors and Affiliations

  1. The Eppley Institute for Research in Cancer; Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198-6805, Omaha, NE, USA

    Parviz M. Pour M.D.

  2. Department of Oncological Pathology, Cancer Center, Nara Medical College, Kashihara, Nara, 634, Japan

    Yoichi Konishi M.D.

  3. Department of Pathology, Academy Hospital Jette, Free University of Brussels, 1090, Brussels, Belgium

    Günter Klöppel M.D.

  4. Department of Pathology, Dartmouth Medical School, 03756, Hanover, NH, USA

    Daniel S. Longnecker M.D.

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© 1994 Springer-Verlag Tokyo

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Pour, P.M., Konishi, Y., Klöppel, G., Longnecker, D.S. (1994). Preneoplastic Lesions of the Exocrine Pancreas. In: Pour, P.M., Konishi, Y., Klöppel, G., Longnecker, D.S. (eds) Atlas of Exocrine Pancreatic Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68311-7_16

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  • DOI: https://doi.org/10.1007/978-4-431-68311-7_16

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68313-1

  • Online ISBN: 978-4-431-68311-7

  • eBook Packages: Springer Book Archive

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