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The Role of Manganese Superoxide Dismutase in the Acquisition of Tolerance of the Heart to Ischemia: Molecular Adaptation to Ischemia

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Cardiac-Vascular Remodeling and Functional Interaction

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Summary

The heart acquires tolerance to ischemic stress after exposure to brief, nonlethal ischemia (ischemic preconditioning). We examined the mechanism of tolerance acquisition from the aspect of oxygen radical metabolism in the heart. Manganese superoxide dismutase (Mn-SOD), which scavenges the initial reductive metabolite of molecular oxygen on ischemia-reperfusion, was induced after various external stimuli including heat shock, α1-adrenergic stimulation, and ischemia (hypoxia). The nduction was blocked by a protein kinase C (PKC) inhibitor, staurosporine, and the specific inhibition of the Mn-SOD induction by antisense oligodeoxyribonucleotides abolished acquisition of tolerance after the stimuli. Therefore, we propose that the de novo synthesis of Mn-SOD could be one of the molecular mechanisms by which the heart adapts to ischemic stress.

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Author information

Authors and Affiliations

  1. Department of Medicine and Pathophysiology, Japan

    Masashi Nishida, Tsunehiko Kuzuya & Michihiko Tada

  2. First Department of Medicine, Osaka University Medical School, Suita, Osaka, 565, Japan

    Masashi Nishida, Tsunehiko Kuzuya, Shiro Hoshida, Nobushige Yamashita, Masatsugu Hori & Michihiko Tada

Authors
  1. Masashi Nishida
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  2. Tsunehiko Kuzuya
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  3. Shiro Hoshida
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  4. Nobushige Yamashita
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  5. Masatsugu Hori
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  6. Michihiko Tada
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Editors and Affiliations

  1. First Department of Internal Medicine, Fukushima Medical College, Hikariga-oka 1, 960-12, Fukushima, Japan

    Yukio Maruyama M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565, Japan

    Masatsugu Hori M.D., Ph.D. (Chief) (Chief)

  3. College of Veterinary Medicine, Auburn University, 106 Greene Hall, 36849-5517, Auburn, AL, USA

    Joseph S. Janicki Ph.D. (Professor, Associate Dean of Research and Graduate Studies) (Professor, Associate Dean of Research and Graduate Studies)

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© 1997 Springer Japan

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Nishida, M., Kuzuya, T., Hoshida, S., Yamashita, N., Hori, M., Tada, M. (1997). The Role of Manganese Superoxide Dismutase in the Acquisition of Tolerance of the Heart to Ischemia: Molecular Adaptation to Ischemia. In: Maruyama, Y., Hori, M., Janicki, J.S. (eds) Cardiac-Vascular Remodeling and Functional Interaction. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67041-4_6

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  • DOI: https://doi.org/10.1007/978-4-431-67041-4_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67043-8

  • Online ISBN: 978-4-431-67041-4

  • eBook Packages: Springer Book Archive

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