Discrepancy of Recovery Times Related to Potency Between Atracurium and Mivacurium Simultaneously Administered into the Isolated Forearms
The recovery from potent non-depolarizing muscle relaxants is slower than that from the less potent agents(1). However the recovery time for mivacurium(MIV), which is more potent than atracurium(ATR), is faster than that of ATR after systemic administration(2). This discrepancy may be due to the rapid hydrolysis by plasma cholinesterase in MIV and more persistent plasma level in ATR. In an attempt to confirm this, we have compared the recovery times following simultaneous administration of equipotent doses of ATR and MIV into the two isolated forearms of a human volunteer(3).